Dealcoholized red wine reverse vascular remodeling in an experimental model of metabolic syndrome: role of NAD(P)H oxidase and eNOS activity

2010 ◽  
Vol 1 (1) ◽  
pp. 124 ◽  
Author(s):  
Marcela Alejandra Vazquez-Prieto ◽  
Nicolás Federico Renna ◽  
Carina Lembo ◽  
Emiliano Raúl Diez ◽  
Roberto Miguel Miatello
Keyword(s):  
Metabolic Syndrome ◽  
Experimental Model ◽  
Vascular Remodeling ◽  
Red Wine ◽  
Enos Activity

scholarly journals Role of Cox-2 in Vascular Inflammation: An Experimental Model of Metabolic Syndrome

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Nicolás F. Renna ◽  
Emiliano R. Diez ◽  
Carina Lembo ◽  
Roberto M. Miatello
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Drinking Water ◽  
Experimental Model ◽  
Vascular Remodeling ◽  
Vascular Inflammation ◽  
Left Ventricular ◽  
Wky Rats ◽  
Cox 2

The objective of this work was to demonstrate the role of COX-2 enzyme at the vascular in experimental model of metabolic syndrome. SHR male WKY rats were employed; they were distributed in 8 groups (n=8each): control (W); W + L: WKY rats receiving 20 mg/kg of lumiracoxib by intraesophageal administration; SHR; SHR + L: SHR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Rats (FFR): WKY rats receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; FFR + L: FFR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Hypertensive Rats (FFHR): SHR receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; and FFHR + L: FFHR + 20 mg/kg of lumiracoxib by intraesophageal administration. Metabolic variables, blood pressure, morphometric variables, and oxidative stress variables were evaluated; also MMP-2 and MMP-9 (collagenases), VCAM-1, and NF-κB by Westernblot or IFI were evaluated. FFHR presented all variables of metabolic syndrome; there was also an increase in oxidative stress variables; vascular remodeling and left ventricular hypertrophy were evidenced along with a significant increase in the expression of the mentioned proinflammatory molecules and increased activity and expression of collagenase. Lumiracoxib was able to reverse vascular remodeling changes and inflammation, demonstrating the involvement of COX-2 in the pathophysiology of vascular remodeling in this experimental model.

scholarly journals Role of MicroRNA-134-5p in Metabolic Syndrome-Associated Pulmonary Hypertension in Heart Failure with Preserved Ejection Fraction

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Aidan Hannon ◽  
Jia-Rong Jheng ◽  
Gunner Halliday ◽  
Yen-Chun Lai
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Vascular Remodeling ◽  
Cellular Proliferation ◽  
National Institutes Of Health ◽  
Pulmonary Vasculature ◽  
Preserved Ejection Fraction ◽  
Pulmonary Vascular Remodeling ◽  
Obesity And Diabetes

Background: Pulmonary hypertension in heart failure with preserved ejection fraction (PH-HFpEF) is the most common cause of PH worldwide. It is closely linked to risk factors for metabolic syndrome, including obesity and diabetes - factors known to increase proliferation and migration of pulmonary artery smooth muscle cells (PASMCs), leading to pulmonary vascular remodeling. Qualitative studies have shown that patients with progressive vascular abnormalities develop more severe symptoms and suffer frequent hospitalization. However, underlying mechanisms involved in the regulation of pulmonary vascular remodeling in metabolic syndrome-associated PH-HFpEF are still unclear. Aim: We have recently observed decreased levels of the tumor suppressor WW domain-containing oxidoreductase (WWOX), which plays a housekeeping role in repressing cellular proliferation, in PASMCs isolated from rats with experimental PH-HFpEF and human subjects with obesity and diabetes. As microRNAs (miRNAs) have been shown to regulate WWOX expression in cancers, here we aimed at examining the involvement of miRNAs in WWOX-associated pulmonary vasculature regulation in metabolic syndrome-associated PH-HFpEF. Methods and Results: Among miRNAs that have been associated with reduced WWOX expression, including miR -134-5p, -153-3p, -29a-3b, -29b-3p and -187-5p, we found that miR-134-5p was significantly increased in PASMCs of obese and diabetic subjects. To determine the role of miR-134-5p in the regulation of WWOX in the pulmonary vasculature, we applied exogenous miR-134-5p to human PASMCs. Treatment with miR-134-5p decreased WWOX expression, increased PCNA expression (a cell proliferation marker) and enhanced cellular proliferation. Additionally, human PASMCs challenged with high concentration of glucose, palmitic acid and insulin, which mimic hyperglycemic, hyperlipidemic and hyperinsulinemic conditions, exhibited increased miR-134-5p, accompanied by elevated cellular proliferation.  Conclusions: These studies suggest that miR-134-5p may have a potential role in metabolic syndrome-associated PH-HFpEF through regulating WWOX in the pulmonary vasculature. These studies identify miR-134-5p as a potential therapeutic target for the treatment of metabolic syndrome-associated PH-HFpEF. This project was funded, in part, with support from the NIH NHLBI Short-Term Training Program in Biomedical Sciences Grant funded, in part by T35HL110854 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Aqueous Garlic Extracts Prevent Oxidative Stress and Vascular Remodeling in an Experimental Model of Metabolic Syndrome

2010 ◽  
Vol 58 (11) ◽  
pp. 6630-6635 ◽  
Author(s):  
Marcela Alejandra Vazquez-Prieto ◽  
Roxana Elizabeth González ◽  
Nicolás Federico Renna ◽  
Claudio Rómulo Galmarini ◽  
Roberto Miguel Miatello
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Experimental Model ◽  
Vascular Remodeling

scholarly journals Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Nathalia Bernardes ◽  
Danielle da Silva Dias ◽  
Filipe Fernandes Stoyell-Conti ◽  
Janaina de Oliveira Brito-Monzani ◽  
Christiane Malfitano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Experimental Model ◽  
And Oxidative Stress

Glucocorticoid-induced metabolic syndrome: establishing the role of AgRP

2018 ◽  
Author(s):  
Charlotte Sefton ◽  
Erika Harno ◽  
Alison Davies ◽  
Tiffany-Jayne Allen ◽  
Jonathan R Wray ◽  
...  
Keyword(s):  
Metabolic Syndrome

The role of omentin in inflammation and metabolic syndrome risk assessment in women with PCO-S

2019 ◽  
Author(s):  
Iwona Zieleń-Zynek ◽  
Joanna Kowalska ◽  
Nowak Justyna ◽  
Barbara Zubelewicz-Szkodzińska
Keyword(s):  
Risk Assessment ◽  
Metabolic Syndrome

Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

2020 ◽  
pp. 23-32
Author(s):  
Elena Korneeva ◽  
Mikhail Voevoda ◽  
Sergey Semaev ◽  
Vladimir Maksimov
Keyword(s):  
Metabolic Syndrome ◽  
High Risk ◽  
Arterial Hypertension ◽  
Genetic Factors ◽  
Young Patients ◽  
Integrin Αiibβ3 ◽  
Ace Gene ◽  
The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

Use of mesenchymal stem cells in an experimental model of metabolic syndrome complicated with cardiomyopathy

2018 ◽  
Vol 22 (1) ◽  
pp. 207-211
Author(s):  
Nagwa Ahmad ◽  
Esam Abdel Raheem ◽  
Hanan Fouad ◽  
Tahia Saleem
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Experimental Model
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