scholarly journals Exploring the energy landscape of a molecular engineered analog of a tumor-homing peptide

2011 ◽  
Vol 13 (21) ◽  
pp. 9986 ◽  
Author(s):  
Guillem Revilla-López ◽  
Juan Torras ◽  
Ruth Nussinov ◽  
Carlos Alemán ◽  
David Zanuy
Keyword(s):  
Energy Landscape ◽  
Tumor Homing ◽  
Homing Peptide

scholarly journals Ultralong tumor retention of theranostic nanoparticles with short peptide-enabled active tumor homing

2019 ◽  
Vol 6 (9) ◽  
pp. 1845-1853 ◽  
Author(s):  
Lihua Li ◽  
Yao Lu ◽  
Zefeng Lin ◽  
Angelina S. Mao ◽  
Ju Jiao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Tumor ◽  
Short Peptide ◽  
Highly Efficient ◽  
Bimodal Imaging ◽  
Theranostic Nanoparticles ◽  
Tumor Homing ◽  
Homing Peptide ◽  
Tumor Retention

A short breast tumor-homing peptide can guide the theranostic nanoparticles to the tumors and enable their ultralong tumor retention, leading to highly efficient targeted breast cancer CT/MRI bimodal imaging and photothermal-chemotherapy.

scholarly journals Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

2016 ◽  
Vol 2 (5) ◽  
pp. e1600349 ◽  
Author(s):  
Anna King ◽  
Cornelia Ndifon ◽  
Sylvia Lui ◽  
Kate Widdows ◽  
Venkata R. Kotamraju ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Targeted Delivery ◽  
Normal Development ◽  
Coated Nanoparticles ◽  
Mouse Placenta ◽  
Pregnant Mice ◽  
Tumor Homing ◽  
Homing Peptide ◽  
And Function ◽  
Proof Of Principle

The availability of therapeutics to treat pregnancy complications is severely lacking mainly because of the risk of causing harm to the fetus. As enhancement of placental growth and function can alleviate maternal symptoms and improve fetal growth in animal models, we have developed a method for targeted delivery of payloads to the placenta. We show that the tumor-homing peptide sequences CGKRK and iRGD bind selectively to the placental surface of humans and mice and do not interfere with normal development. Peptide-coated nanoparticles intravenously injected into pregnant mice accumulated within the mouse placenta, whereas control nanoparticles exhibited reduced binding and/or fetal transfer. We used targeted liposomes to efficiently deliver cargoes of carboxyfluorescein and insulin-like growth factor 2 to the mouse placenta; the latter significantly increased mean placental weight when administered to healthy animals and significantly improved fetal weight distribution in a well-characterized model of fetal growth restriction. These data provide proof of principle for targeted delivery of drugs to the placenta and provide a novel platform for the development of placenta-specific therapeutics.

Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging

2020 ◽  
Vol 31 (6) ◽  
pp. 1382-1386 ◽  
Author(s):  
Hui Zhou ◽  
Shanshan Li ◽  
Xiaodong Zeng ◽  
Mengxian Zhang ◽  
Lin Tang ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Tumor Imaging ◽  
Tumor Homing ◽  
Homing Peptide

scholarly journals Treatment of Peritoneal Carcinomatosis by Targeted Delivery of the Radio-Labeled Tumor Homing Peptide 213Bi-DTPA-[F3]2 into the Nucleus of Tumor Cells

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5715 ◽  
Author(s):  
Enken Drecoll ◽  
Florian C. Gaertner ◽  
Matthias Miederer ◽  
Birgit Blechert ◽  
Mario Vallon ◽  
...  
Keyword(s):  
Peritoneal Carcinomatosis ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Tumor Homing ◽  
Homing Peptide

scholarly journals A New Phage-Display Tumor-Homing Peptide Fused to Antiangiogenic Peptide Generates a Novel Bioactive Molecule with Antimelanoma Activity

2011 ◽  
Vol 9 (11) ◽  
pp. 1471-1478 ◽  
Author(s):  
Alisson L. Matsuo ◽  
Maria A. Juliano ◽  
Carlos R. Figueiredo ◽  
Wagner L. Batista ◽  
Aparecida S. Tanaka ◽  
...  
Keyword(s):  
Phage Display ◽  
Tumor Homing ◽  
Homing Peptide ◽  
Bioactive Molecule

Abstract 382: In-vivo imaging of lung cancer using tumor homing peptide coated nanoparticles

2012 ◽  
Author(s):  
Apurva R. Patel ◽  
Ed Lim ◽  
Ning Zhang ◽  
Kevin Francis ◽  
Stephen Safe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
In Vivo Imaging ◽  
Coated Nanoparticles ◽  
Tumor Homing ◽  
Homing Peptide

scholarly journals Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Emiliano Cocco ◽  
Francesca Casagrande ◽  
Stefania Bellone ◽  
Christine E Richter ◽  
Marta Bellone ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Clostridium Perfringens ◽  
Human Ovarian Cancer ◽  
Clostridium Perfringens Enterotoxin ◽  
Terminal Fragment ◽  
Tumor Homing ◽  
Homing Peptide ◽  
Carboxy Terminal
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