In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles

2010 ◽  
Vol 46 (31) ◽  
pp. 5668 ◽  
Author(s):  
Heebeom Koo ◽  
Hyejung Lee ◽  
Sojin Lee ◽  
Kyung Hyun Min ◽  
Min Sang Kim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Tumor Diagnosis ◽  
Ph Responsive

Photoacoustic Imaging Application in Tumor Diagnosis and Treatment Monitoring

2007 ◽  
Vol 364-366 ◽  
pp. 1100-1104 ◽  
Author(s):  
Liang Zhong Xiang ◽  
Fei Fan Zhou
Keyword(s):  
Photodynamic Therapy ◽  
Photoacoustic Imaging ◽  
Tumor Therapy ◽  
Single Pulse ◽  
Treatment Monitoring ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Imaging Application ◽  
Early Tumor

Photoacoustic imaging (also called optoacoustic or thermoacoustic imaging) can image vascularity clearly with simultaneous high contrast and high spatial resolution, and has the potential to be an application for tumor diagnosis and treatment monitoring. In a unique photoacoustic system, a single pulse laser beam was used as the light source for both cancer treatment and for concurrently generating ultrasound signals for photoacoustic imaging. The photoacoustic system was used to detect early tumor on the rat back, and the vascular structure around the tumor could be imaged clearly with optimal contrast. This system was also used to monitoring damage of the vascular structures before, during and after photodynamic therapy of tumor. This work demonstrates that photoacoustic imaging can potentially be used to guide photodynamic therapy and other phototherapies using vascular changes during treatment. Prospective application of photoacoustic imaging is to characterize and monitor the accumulation of gold nanoshells in vivo to guide nanoshell-based thermal tumor therapy.

scholarly journals A Tumor-pH-Responsive Supramolecular Photosensitizer for Activatable Photodynamic Therapy with Minimal In Vivo Skin Phototoxicity

Theranostics ◽  
2017 ◽  
Vol 7 (10) ◽  
pp. 2746-2756 ◽  
Author(s):  
Xingshu Li ◽  
Bi-Yuan Zheng ◽  
Mei-Rong Ke ◽  
Yongfan Zhang ◽  
Jian-Dong Huang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Ph Responsive ◽  
Tumor Ph

Real-time monitoring of a controlled drug delivery system in vivo: construction of a near infrared fluorescence monomer conjugated with pH-responsive polymeric micelles

2016 ◽  
Vol 4 (19) ◽  
pp. 3377-3386 ◽  
Author(s):  
Li Chen ◽  
Bizheng Chen ◽  
Xiaodong Liu ◽  
Yujie Xu ◽  
Lifen Zhang ◽  
...  
Keyword(s):  
Real Time ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Controlled Drug Delivery ◽  
Polymeric Micelle ◽  
Amphiphilic Copolymer ◽  
Tumor Site ◽  
Ph Responsive ◽  
Controlled Drug Delivery System

A self-assembled polymeric micelle from multifunctional amphiphilic copolymer with NIR and pH-sensitive groups can be used to monitor the dynamic process of its arriving at the tumor site in real time.

In-vitro and in-vivo evaluation of pH-responsive polymeric micelles in a photodynamic cancer therapy model

2001 ◽  
Vol 53 (2) ◽  
pp. 155-166 ◽  
Author(s):  
J. Taillefer ◽  
N. Brasseur ◽  
J. E. van Lier ◽  
V. Lenaerts ◽  
D. Le Garrec ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
In Vivo Evaluation ◽  
Photodynamic Cancer Therapy ◽  
Therapy Model

A pH-responsive stellate mesoporous silica based nanophotosensitizer for in vivo cancer diagnosis and targeted photodynamic therapy

2019 ◽  
Vol 7 (1) ◽  
pp. 211-219 ◽  
Author(s):  
Ai-Lan Lin ◽  
Song-Zi Li ◽  
Cai-Hong Xu ◽  
Xing-Shu Li ◽  
Bi-Yuan Zheng ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Cancer Diagnosis ◽  
Tumor Site ◽  
Ph Responsive ◽  
Targeted Photodynamic Therapy

A novel stellate mesoporous silica-based pH-responsive nanophotosensitizer can be localized and specifically activated at tumor site for cancer diagnosis and targeted PDT.

scholarly journals Microfluidic-Assisted Preparation of Targeted pH-Responsive Polymeric Micelles Improves Gemcitabine Effectiveness in PDAC: In Vitro Insights

Cancers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 5
Author(s):  
Rosa Iacobazzi ◽  
Ilaria Arduino ◽  
Roberta Di Fonte ◽  
Angela Lopedota ◽  
Simona Serratì ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Colloidal Stability ◽  
Polymeric Micelles ◽  
3D Models ◽  
Physiological Model ◽  
Ductal Adenocarcinoma ◽  
Ph Responsive ◽  
Drug Receptor

Pancreatic ductal adenocarcinoma (PDAC) represents a great challenge to the successful delivery of the anticancer drugs. The intrinsic characteristics of the PDAC microenvironment and drugs resistance make it suitable for therapeutic approaches with stimulus-responsive drug delivery systems (DDSs), such as pH, within the tumor microenvironment (TME). Moreover, the high expression of uPAR in PDAC can be exploited for a drug receptor-mediated active targeting strategy. Here, a pH-responsive and uPAR-targeted Gemcitabine (Gem) DDS, consisting of polymeric micelles (Gem@TpHResMic), was formulated by microfluidic technique to obtain a preparation characterized by a narrow size distribution, good colloidal stability, and high drug-encapsulation efficiency (EE%). The Gem@TpHResMic was able to perform a controlled Gem release in an acidic environment and to selectively target uPAR-expressing tumor cells. The Gem@TpHResMic displayed relevant cellular internalization and greater antitumor properties than free Gem in 2D and 3D models of pancreatic cancer, by generating massive damage to DNA, in terms of H2AX phosphorylation and apoptosis induction. Further investigation into the physiological model of PDAC, obtained by a co-culture of tumor spheroids and cancer-associated fibroblast (CAF), highlighted that the micellar system enhanced the antitumor potential of Gem, and was demonstrated to overcome the TME-dependent drug resistance. In vivo investigation is warranted to consider this new DDS as a new approach to overcome drug resistance in PDAC.

Optimizing pH-responsive Polymeric Micelles for Drug Delivery in a Cancer Photodynamic Therapy Model

2002 ◽  
Vol 10 (5) ◽  
pp. 429-437 ◽  
Author(s):  
D. Le Garrec ◽  
J. Taillefer ◽  
J.E. Van Lier ◽  
V. Lenaerts ◽  
J.-C. Leroux
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Ph Responsive ◽  
Therapy Model
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