Identification and semi-quantitative analysis of parabens and UV filters in cosmetic products by direct-analysis-in-real-time mass spectrometry and gas chromatography with mass spectrometric detection

2011 ◽  
Vol 3 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Manuela Haunschmidt ◽  
Wolfgang Buchberger ◽  
Christian W. Klampfl ◽  
Robert Hertsens
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Quantitative Analysis ◽  
Real Time ◽  
Direct Analysis ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Uv Filters ◽  
Cosmetic Products

scholarly journals IDENTIFICATION OF CANNABIMIMETIC MDMB(N)-073F METABOLITES IN URINE BY METHOD OF GAS CHROMATOGRAPHY WITH MASS SPECTROMETRIC DETECTION

2019 ◽  
Vol 7 (2) ◽  
pp. 70-83 ◽  
Author(s):  
S. S. Kataev ◽  
O. N. Dvorskaya ◽  
M. A. Gofenberg
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Acute Poisoning ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Urine Samples ◽  
Instrumental Method ◽  
Phase Extraction

Background. At the beginning of 2019, the use of a new representative of synthetic cannabimimetics of the methylbutanoate indazole carboxamides group, MDMB(N)-073F, was recorded in a number of regions in the Russian Federation. Characteristic features of the pharmacological effect, the clinical picture of MDMB(N)-073F poisoning have not been studied, the psychoactive effects produced by MDMB(N)-073F remain unexplored. In this regard, the study of the new cannabimimetic metabolism is an important aspect in establishing the fact of taking MDMB(N)-073F during expert studies of biological objects.The aim of the research is identifying metabolites of synthetic MDMB(N)-73F cannabimimetics in real urine samples using solid-phase extraction (SPE) and gas chromatography (GC) with mass spectrometric detection (GC-MS).Materials and methods. 10 urine samples were collected from March 15 to March 29, 2019. 8 urine samples were taken from the medical examination offices of the city of Yekaterinburg and the Sverdlovsk region from the persons examined for intoxication; 2 urine samples were obtained from the patients of the Sverdlovsk regional center of acute poisoning upon enrolment to the toxic-intensive care unit with a preliminary diagnosis of “acute poisoning by synthetic cannabimimetics”. In the research, SampliQ EVIDEX-200 mg – 3 ml (Agilent, USA) cartridges were used for the sample preparation; β-glucuronidase Type HP-2, From Helix Pomatia, 100000 U/ml (Sigma-ALDRICH CHEMI, Germany) was used for enzymatic hydrolysis. Gas chromatography – mass spectrometry with the use of Agilent 7820 gas chromatograph with Agilent 5975 mass selective detector (Agilent, USA) was used as an instrumental method of the analysis.Results. The metabolites that make it possible to establish the fact of taking MDMB(N)-073F cannabimimetics via urine screening procedure to detect the presence of narcotic and medicinal substances with the use of solid-phase extraction and gas chromatography methods with mass spectrometry, have been described. The major metabolites MDMB(N)-073F in the urine of smoking mixtures consumers have been identified. The metabolism of MDMB(N)-073F has been found to be mainly due to hydrolysis of the ester group, hydroxylation, oxidative defluorination and N-dealkylation. Most of the resulting metabolites are excreted in the urine in the conjugated form.Conclusion. Gas chromatographic and mass spectrometric characteristics of some derivatives of the main metabolites of the new synthetic MDMB(N)-073F cannabimimetic have been obtained. This data can be used in the practice of forensic chemical and chemical toxicological analysis.

scholarly journals Ambient Mass Spectrometric Detection of Organometallic Compounds Using Direct Analysis in Real Time

2009 ◽  
Vol 81 (23) ◽  
pp. 9834-9839 ◽  
Author(s):  
Daniel L. G. Borges ◽  
Ralph E. Sturgeon ◽  
Bernhard Welz ◽  
Adilson J. Curtius ◽  
Zoltán Mester
Keyword(s):  
Real Time ◽  
Organometallic Compounds ◽  
Direct Analysis ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection

Capillary Column Gas Chromatographic Determination of Ethyl Carbamate in Alcoholic Beverages with Confirmation by Gas Chromatography/Mass Spectrometry

1987 ◽  
Vol 70 (4) ◽  
pp. 749-751 ◽  
Author(s):  
Henry B S Conacher ◽  
Denis B Page ◽  
Benjamin P Y Lau ◽  
James F Lawrence ◽  
Ruth Bailey ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Capillary Column ◽  
Methylene Chloride ◽  
Ethyl Carbamate ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Alcoholic Beverages ◽  
Gas Chromatography Mass Spectrometry ◽  
Acetate Solution

Abstract A method is described for determining ethyl carbamate at low \i%l kg levels in several types of alcoholic beverages by capillary column gas chromatography with Hall electrolytic conductivity detection and confirmation by mass spectrometry. Samples are diluted to obtain a uniform concentration of ethanol (ca 10%) then saturated with NaCl and extracted with methylene chloride. Extracts are evaporated to a small volume and injected in ethyl acetate solution for chromatographic analysis. The method was evaluated by 5 laboratories, 4 employing the Hall detector and one using mass spectrometric detection. Overall between-laboratory mean percent recoveries were: wine, 85.3 ± 21.0% coefficient of variation (CV) (spiking level 20- 45 μg/kg); sherry, 83.8 ± 16.1% CV (spiking level, 81-142 μg/kg);whiskey, 79.5 ± 13.9% CV (spiking level 127-190 Mg/kg); and brandy, 85.0 ± 12.5% CV (spiking level 297-446 μg/kg). Mass spectrometric results agreed well with the Hall results for all commodities. Detection limits were about 5 μg/kg for the Hall detector and about 0.5 μg/kg for mass spectrometric detection.

scholarly journals DART-MS analysis of inorganic explosives using high temperature thermal desorption

2017 ◽  
Vol 9 (34) ◽  
pp. 4988-4996 ◽  
Author(s):  
Thomas P. Forbes ◽  
Edward Sisco ◽  
Matthew Staymates ◽  
Greg Gillen
Keyword(s):  
High Temperature ◽  
Real Time ◽  
Thermal Desorption ◽  
Direct Analysis ◽  
Mass Spectrometric ◽  
Mass Spectrometric Detection ◽  
Resistive Heating ◽  
Ms Analysis

Coupling resistive heating thermal desorption and direct analysis in real time demonstrated trace mass spectrometric detection of inorganic oxidizer explosives.

Capabilities of direct analysis in real time mass spectrometry and gas chromatography–mass spectrometry in the mint oil test

2010 ◽  
Vol 20 (5) ◽  
pp. 299-300 ◽  
Author(s):  
Elena S. Chernetsova ◽  
Yuri Yu. Khomyakov ◽  
Sergey V. Goryainov ◽  
Maxim V. Ovcharov ◽  
Pavel O. Bochkov ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Real Time ◽  
Direct Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry
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