Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer

2010 ◽  
Vol 6 (10) ◽  
pp. 1911 ◽  
Author(s):  
Friederike Teichert ◽  
Richard D. Verschoyle ◽  
Peter Greaves ◽  
Donald J. L. Jones ◽  
Ian D. Wilson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Metabolic Profiling ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Systemic Effects ◽  
Age Dependency

scholarly journals Anti-Cancer Effects of Green Tea Polyphenols Against Prostate Cancer

Molecules ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 193 ◽  
Author(s):  
Yasuyoshi Miyata ◽  
Yohei Shida ◽  
Tomoaki Hakariya ◽  
Hideki Sakai
Keyword(s):  
Prostate Cancer ◽  
Green Tea ◽  
Molecular Mechanisms ◽  
Current Knowledge ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Anti Cancer ◽  
Prevention And Treatment

Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding these anti-cancer effects. In recent years, in addition to prevention, many investigators have shown the efficacy and safety of green tea polyphenols and combination therapies with green tea extracts and anti-cancer agents in in vivo and in vitro studies. Furthermore, numerous studies have revealed the molecular mechanisms of the anti-cancer effects of green tea extracts. We believe that improved understanding of the detailed pathological roles at the molecular level is important to evaluate the prevention and treatment of prostate cancer. Therefore, in this review, we present current knowledge regarding the anti-cancer effects of green tea extracts in the prevention and treatment of prostate cancer, with a particular focus on the molecular mechanisms of action, such as influencing tumor growth, apoptosis, androgen receptor signaling, cell cycle, and various malignant behaviors. Finally, the future direction for the use of green tea extracts as treatment strategies in patients with prostate cancer is introduced.

scholarly journals Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52572 ◽  
Author(s):  
Karishma Gupta ◽  
Vijay S. Thakur ◽  
Natarajan Bhaskaran ◽  
Akbar Nawab ◽  
Melissa A. Babcook ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Prostate Cancer Cells

Metabolic profiling in validation of plasma biomarkers for green tea polyphenols

Metabolomics ◽  
2006 ◽  
Vol 2 (4) ◽  
pp. 235-241 ◽  
Author(s):  
Haitao Luo ◽  
Stephen B. Cox ◽  
Weimin Gao ◽  
Jiahua Yu ◽  
Lili Tang ◽  
...  
Keyword(s):  
Green Tea ◽  
Metabolic Profiling ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Plasma Biomarkers

scholarly journals Prospective randomized trial evaluating blood and prostate tissue concentrations of green tea polyphenols and quercetin in men with prostate cancer

2020 ◽  
Vol 11 (5) ◽  
pp. 4114-4122
Author(s):  
Susanne M. Henning ◽  
Piwen Wang ◽  
Ru-Po Lee ◽  
Amy Trang ◽  
George Husari ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Randomized Trial ◽  
Green Tea ◽  
Epigallocatechin Gallate ◽  
Potential Effect ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Prostate Tissue ◽  
Epicatechin Gallate ◽  
Tissue Concentrations

Epigallocatechin gallate, epicatechin gallate (Green Tea Polyphenols – GTPs) and quercetin (Q) were taken up in prostate tissue after Q and GTP consumption. Our findings herein suggest a potential effect of Q on GTP metabolism.

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