Electrospray mass spectrometry for detailed mechanistic studies of a complex organocatalyzed triple cascade reaction

2011 ◽  
Vol 9 (4) ◽  
pp. 1047-1053 ◽  
Author(s):  
M. Wasim Alachraf ◽  
Peni P. Handayani ◽  
Matthias R. M. Hüttl ◽  
Christoph Grondal ◽  
Dieter Enders ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Cascade Reaction ◽  
Mechanistic Studies

scholarly journals A new charge-tagged proline-based organocatalyst for mechanistic studies using electrospray mass spectrometry

2014 ◽  
Vol 10 ◽  
pp. 2027-2037 ◽  
Author(s):  
J Alexander Willms ◽  
Rita Beel ◽  
Martin L Schmidt ◽  
Christian Mundt ◽  
Marianne Engeser
Keyword(s):  
Mass Spectrometry ◽  
Gas Phase ◽  
Electrospray Mass Spectrometry ◽  
Temporal Evolution ◽  
Mechanistic Studies ◽  
Catalytic Center ◽  
Enamine Catalysis ◽  
Esi Mass Spectrometry ◽  
Catalyzed Reactions ◽  
Gas Phase Fragmentation

A new 4-hydroxy-L-proline derivative with a charged 1-ethylpyridinium-4-phenoxy substituent has been synthesized with the aim of facilitating mechanistic studies of proline-catalyzed reactions by ESI mass spectrometry. The charged residue ensures a strongly enhanced ESI response compared to neutral unmodified proline. The connection by a rigid linker fixes the position of the charge tag far away from the catalytic center in order to avoid unwanted interactions. The use of a charged catalyst leads to significantly enhanced ESI signal abundances for every catalyst-derived species which are the ones of highest interest present in a reacting solution. The new charged proline catalyst has been tested in the direct asymmetric inverse aldol reaction between aldehydes and diethyl ketomalonate. Two intermediates in accordance with the List–Houk mechanism for enamine catalysis have been detected and characterized by gas-phase fragmentation. In addition, their temporal evolution has been followed using a microreactor continuous-flow technique.

Analysis of Trace Level Perchlorate in Drinking Water and Ground Water by Electrospray Mass Spectrometry

1998 ◽  
Author(s):  
Rebecca A. Clewell ◽  
Wayne T. Brashear ◽  
David T. Tsui ◽  
Sanwat Chaudhuri ◽  
Rachel S. Cassady
Keyword(s):  
Mass Spectrometry ◽  
Drinking Water ◽  
Ground Water ◽  
Electrospray Mass Spectrometry ◽  
Trace Level

Determination of the endogenous phosphorylation state of B-50/GAP-43 and neurogranin in different brain regions by electrospray mass spectrometry

FEBS Letters ◽  
1996 ◽  
Vol 389 (3) ◽  
pp. 309-313 ◽  
Author(s):  
Monica Di Luca ◽  
Lucia Pastorino ◽  
Vittorio Raverdino ◽  
Pierre N.E. De Graan ◽  
Antonio Caputi ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry ◽  
Brain Regions ◽  
Phosphorylation State

A polymeric microchip with integrated tips and in situ polymerized monolith for electrospray mass spectrometry

Lab on a Chip ◽  
2005 ◽  
Vol 5 (8) ◽  
pp. 869 ◽  
Author(s):  
Yanou Yang ◽  
Chen Li ◽  
Jun Kameoka ◽  
Kelvin H. Lee ◽  
H. G. Craighead
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Mass Spectrometry
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