Electrospun nanofibers for neural tissue engineering

Nanoscale ◽  
2010 ◽  
Vol 2 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Jingwei Xie ◽  
Matthew R. MacEwan ◽  
Andrea G. Schwartz ◽  
Younan Xia
Keyword(s):  
Tissue Engineering ◽  
Electrospun Nanofibers ◽  
Neural Tissue ◽  
Neural Tissue Engineering

scholarly journals Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 6899
Author(s):  
Beata Niemczyk-Soczynska ◽  
Angelika Zaszczyńska ◽  
Konrad Zabielski ◽  
Pawel Sajkiewicz
Keyword(s):  
Tissue Engineering ◽  
Tissue Regeneration ◽  
Electrospun Nanofibers ◽  
Neural Tissue ◽  
Economic Problem ◽  
Neural Tissue Engineering ◽  
Advantages And Disadvantages ◽  
Polymeric Scaffolds ◽  
Complete Restoration ◽  
Nano Additives

Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but they do not fulfill all of the bone/cartilage and neural tissue engineering requirements such as mechanical properties, biochemical cues or adequate biodegradation. There are still many things to do to provide complete restoration of injured tissues. Recent reports in bone/cartilage and neural tissue engineering give high hopes in designing scaffolds for complete tissue regeneration. This review thoroughly discusses the advantages and disadvantages of currently available commercial scaffolds and sheds new light on the designing of novel polymeric scaffolds composed of hydrogels, electrospun nanofibers, or hydrogels loaded with nano-additives.

scholarly journals Combining electrospun nanofibers with cell-encapsulating hydrogel fibers for neural tissue engineering

2018 ◽  
Vol 29 (13) ◽  
pp. 1625-1642 ◽  
Author(s):  
Ryan J. Miller ◽  
Cheook Y. Chan ◽  
Arjun Rastogi ◽  
Allison M. Grant ◽  
Christina M. White ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Electrospun Nanofibers ◽  
Neural Tissue ◽  
Neural Tissue Engineering

scholarly journals Spidroin Silk Fibers with Bioactive Motifs of Extracellular Proteins for Neural Tissue Engineering

ACS Omega ◽  
2021 ◽  
Author(s):  
Veronica A. Revkova ◽  
Konstantin V. Sidoruk ◽  
Vladimir A. Kalsin ◽  
Pavel A. Melnikov ◽  
Mikhail A. Konoplyannikov ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Neural Tissue ◽  
Extracellular Proteins ◽  
Neural Tissue Engineering ◽  
Silk Fibers

scholarly journals Electrospun Nanofibrous Materials for Neural Tissue Engineering

Polymers ◽  
2011 ◽  
Vol 3 (1) ◽  
pp. 413-426 ◽  
Author(s):  
Yee-Shuan Lee ◽  
Treena Livingston Arinzeh
Keyword(s):  
Tissue Engineering ◽  
Neural Tissue ◽  
Neural Tissue Engineering

Directing Axonal Growth: A Review on the Fabrication of Fibrous Scaffolds That Promotes the Orientation of Axons

Gels ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 25
Author(s):  
Devindraan Sirkkunan ◽  
Belinda Pingguan-Murphy ◽  
Farina Muhamad
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Neuronal Cells ◽  
Neural Tissue ◽  
Axonal Growth ◽  
Structural Proteins ◽  
Neural Cells ◽  
Neural Tissue Engineering ◽  
Fibrous Scaffolds ◽  
Specialized Function

Tissues are commonly defined as groups of cells that have similar structure and uniformly perform a specialized function. A lesser-known fact is that the placement of these cells within these tissues plays an important role in executing its functions, especially for neuronal cells. Hence, the design of a functional neural scaffold has to mirror these cell organizations, which are brought about by the configuration of natural extracellular matrix (ECM) structural proteins. In this review, we will briefly discuss the various characteristics considered when making neural scaffolds. We will then focus on the cellular orientation and axonal alignment of neural cells within their ECM and elaborate on the mechanisms involved in this process. A better understanding of these mechanisms could shed more light onto the rationale of fabricating the scaffolds for this specific functionality. Finally, we will discuss the scaffolds used in neural tissue engineering (NTE) and the methods used to fabricate these well-defined constructs.

scholarly journals Electrospun Polyvinylidene Fluoride-Based Fibrous Scaffolds with Piezoelectric Characteristics for Bone and Neural Tissue Engineering

Nanomaterials ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 952 ◽  
Author(s):  
Li ◽  
Liao ◽  
Tjong
Keyword(s):  
Tissue Engineering ◽  
Polyvinylidene Fluoride ◽  
Neural Tissue ◽  
Electrospinning Process ◽  
Neural Cells ◽  
Neural Tissue Engineering ◽  
Engineering Applications ◽  
Pore Sizes ◽  
Β Phase ◽  
Small Pore

Polyvinylidene fluoride (PVDF) and polyvinylidene fluoride-trifluoroethylene (P(VDF-TrFE) with excellent piezoelectricity and good biocompatibility are attractive materials for making functional scaffolds for bone and neural tissue engineering applications. Electrospun PVDF and P(VDF-TrFE) scaffolds can produce electrical charges during mechanical deformation, which can provide necessary stimulation for repairing bone defects and damaged nerve cells. As such, these fibrous mats promote the adhesion, proliferation and differentiation of bone and neural cells on their surfaces. Furthermore, aligned PVDF and P(VDF-TrFE) fibrous mats can enhance neurite growth along the fiber orientation direction. These beneficial effects derive from the formation of electroactive, polar β-phase having piezoelectric properties. Polar β-phase can be induced in the PVDF fibers as a result of the polymer jet stretching and electrical poling during electrospinning. Moreover, the incorporation of TrFE monomer into PVDF can stabilize the β-phase without mechanical stretching or electrical poling. The main drawbacks of electrospinning process for making piezoelectric PVDF-based scaffolds are their small pore sizes and the use of highly toxic organic solvents. The small pore sizes prevent the infiltration of bone and neuronal cells into the scaffolds, leading to the formation of a single cell layer on the scaffold surfaces. Accordingly, modified electrospinning methods such as melt-electrospinning and near-field electrospinning have been explored by the researchers to tackle this issue. This article reviews recent development strategies, achievements and major challenges of electrospun PVDF and P(VDF-TrFE) scaffolds for tissue engineering applications.

Nanotechnologies in Neural Tissue Engineering

2008 ◽  
pp. 295-309
Author(s):  
Julie Yeh ◽  
Vivek Mukhatyar ◽  
Ravi Bellamkonda
Keyword(s):  
Tissue Engineering ◽  
Neural Tissue ◽  
Neural Tissue Engineering
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