Aim and Objective:
Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in
the presence of the catalytic amount of acetic acid in ethanol.
Materials and Methods:
The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis.
Results:
The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as
Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and
Salmonella typhimurium.
Conclusion:
All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of
them demonstrated antibacterial activity against E. coli.