X-Ray absorption in homogeneous catalysis research: the iron-catalyzed Michael addition reaction by XAS, RIXS and multi-dimensional spectroscopy

2010 ◽  
Vol 12 (21) ◽  
pp. 5575 ◽  
Author(s):  
Matthias Bauer ◽  
Christoph Gastl
Keyword(s):  
Homogeneous Catalysis ◽  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction ◽  
X Ray ◽  
Catalysis Research ◽  
X Ray Absorption

scholarly journals “Free of Base” Sulfa-Michael Addition for Novel o-Carboranyl-DL-Cysteine Synthesis

Crystals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1133
Author(s):  
Julia Laskova ◽  
Irina Kosenko ◽  
Ivan Ananyev ◽  
Marina Stogniy ◽  
Igor Sivaev ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Neutron Capture Therapy ◽  
Michael Addition Reaction ◽  
X Ray Diffraction ◽  
Deuterium Label ◽  
X Ray ◽  
Boron Neutron Capture ◽  
Cysteine Synthesis ◽  
Base Method

The sulfa-Michael addition reaction was applied for the two-step synthesis of o-carboranyl cysteine 1-HOOCCH(NH2)CH2S-1,2-C2B10H11 from the trimethylammonium salt of 1-mercapto-o-carborane and methyl 2-acetamidoacrylate. To avoid the decapitation of o-carborane into its nido-form, the “free of base” method under mild conditions in a system of two immiscible solvents toluene-H2O was developed. The replacement of H2O by 2H2O resulted in carboranyl-cysteine containing a deuterium label at the α-position of the amino acid 1-HOOCCD(NH2)CH2S-1,2-C2B10H11. The structure of the protected o-carboranyl cysteine was determined by single-crystal X-ray diffraction. The obtained compounds can be considered as potential agents for the Boron Neutron Capture Therapy of cancer.

Cupin Variants as Macromolecular Ligand Library for Stereoselective Michael Addition of Nitroalkanes

2019 ◽  
Author(s):  
Nobutaka Fujieda ◽  
Miho Yuasa ◽  
Yosuke Nishikawa ◽  
Genji Kurisu ◽  
Shinobu Itoh ◽  
...  
Keyword(s):  
Michael Addition ◽  
In Silico ◽  
Addition Reaction ◽  
Single Point ◽  
Point Mutations ◽  
Unsaturated Ketone ◽  
Michael Addition Reaction ◽  
Beta Barrel ◽  
Cupin Superfamily ◽  
Single Point Mutations

Cupin superfamily proteins (TM1459) work as a macromolecular ligand framework with a double-stranded beta-barrel structure ligating to a Cu ion through histidine side chains. Variegating the first coordination sphere of TM1459 revealed that H52A and H54A/H58A mutants effectively catalyzed the diastereo- and enantio-selective Michael addition reaction of nitroalkanes to an α,β-unsaturated ketone. Moreover, in silico substrate docking signified C106N and F104W single-point mutations, which inverted the diastereoselectivity of H52A and further improved the stereoselectivity of H54A/H58A, respectively.

Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones

Synthesis ◽  
2021 ◽  
Author(s):  
Azim Ziyaei Halimehjani ◽  
Petr Beier ◽  
Maryam Khalili Foumeshi ◽  
Ali Alaei ◽  
Blanka Klepetářová
Keyword(s):  
Amino Acids ◽  
Carbon Disulfide ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Addition Reaction ◽  
Primary Amines ◽  
Oxidation Reactions ◽  
Michael Addition Reaction ◽  
Synthetic Utility ◽  
Reaction Proceeds

AbstractThiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeds via a domino alkylation/intramolecular Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions.

Bisphosphine catalyzed sequential [3 + 2] cycloaddition and Michael addition of ynones with benzylidenepyrazolones via dual α′,α′-C(sp3)–H bifunctionalization to construct cyclopentanone-fused spiro-pyrazolones

2018 ◽  
Vol 16 (48) ◽  
pp. 9461-9471 ◽  
Author(s):  
Jiayong Zhang ◽  
Zhiwei Miao
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction

A sequential [3 + 2] cycloaddition and Michael addition reaction of ynones with benzylidenepyrazolones afforded cyclopentanone-fused spiro-pyrazolones catalyzed by DPPB via dual α′,α′-C(sp3)–H bifunctionalization.

ChemInform Abstract: Organocatalyzed Michael Addition Reaction by Novel (2R,3aS,7aS)-Octahydroindole-2-carboxylic Acid, a New Fused Proline.

ChemInform ◽  
2011 ◽  
Vol 42 (21) ◽  
pp. no-no
Author(s):  
David Roca-Lopez ◽  
Pedro Merino ◽  
Francisco J. Sayago ◽  
Carlos Cativiela ◽  
Raquel P. Herrera
Keyword(s):  
Carboxylic Acid ◽  
Michael Addition ◽  
Addition Reaction ◽  
Michael Addition Reaction

TiO2 nano crystallites catalyzed water mediated microwave assisted regioselective three component domino hydrolysis/aldol condensation/Michael addition reaction of 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-one

RSC Advances ◽  
2014 ◽  
Vol 4 (100) ◽  
pp. 57016-57025 ◽  
Author(s):  
Eethamukkala Ubba ◽  
Fazlur-Rahman Nawaz Khan ◽  
Euh Duck Jeong ◽  
Eun Hyuk Chung
Keyword(s):  
Michael Addition ◽  
Addition Reaction ◽  
Aldol Condensation ◽  
Michael Addition Reaction ◽  
Microwave Assisted ◽  
Nano Crystalline

Microwave supported, water intervened, nano crystalline TiO2 catalyzed synthesis of 3-(1,5-dioxo-1,5-diphenylpentan-3-yl)quinolin-2(1H)-ones, is described.

KF/Al2O3as a Highly Efficient, Green, Heterogeneous, and Reusable Catalytic System for the Solvent-Free Synthesis of Carboacyclic Nucleosides via Michael Addition Reaction

2008 ◽  
Vol 39 (1) ◽  
pp. 139-157 ◽  
Author(s):  
Abdolkarim Zare ◽  
Alireza Hasaninejad ◽  
Mohammad Hassan Beyzavi ◽  
Ahmad Reza Moosavi Zare ◽  
Ali Khalafi-Nezhad ◽  
...  
Keyword(s):  
Catalytic System ◽  
Michael Addition ◽  
Addition Reaction ◽  
Solvent Free ◽  
Michael Addition Reaction ◽  
Highly Efficient ◽  
Solvent Free Synthesis
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