Single-ion magnets based on mononuclear lanthanide complexes with chiral Schiff base ligands [Ln(FTA)3L] (Ln = Sm, Eu, Gd, Tb and Dy)

2010 ◽  
Vol 46 (17) ◽  
pp. 2929 ◽  
Author(s):  
Dong-Ping Li ◽  
Tian-Wei Wang ◽  
Cheng-Hui Li ◽  
Dong-Sheng Liu ◽  
Yi-Zhi Li ◽  
...  
Keyword(s):  
Schiff Base ◽  
Lanthanide Complexes ◽  
Schiff Base Ligands ◽  
Chiral Schiff Base

scholarly journals In Vitro Evaluation of the Potential Pharmacological Activity and Molecular Targets of New Benzimidazole-Based Schiff Base Metal Complexes

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 728
Author(s):  
Alberto Aragón-Muriel ◽  
Yamil Liscano ◽  
Yulieth Upegui ◽  
Sara M. Robledo ◽  
María Teresa Ramírez-Apan ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Lanthanide Complexes ◽  
Human Tumor ◽  
Model Membranes ◽  
Leishmania Braziliensis ◽  
Cytotoxic Activities ◽  
Schiff Base Ligands ◽  
Major Interest

Metal-based drugs, including lanthanide complexes, have been extremely effective in clinical treatments against various diseases and have raised major interest in recent decades. Hence, in this work, a series of lanthanum (III) and cerium (III) complexes, including Schiff base ligands derived from (1H-benzimidazol-2-yl)aniline, salicylaldehyde, and 2,4-dihydroxybenzaldehyde were synthesized and characterized using different spectroscopic methods. Besides their cytotoxic activities, they were examined in human U-937 cells, primate kidney non-cancerous COS-7, and six other, different human tumor cell lines: U251, PC-3, K562, HCT-15, MCF-7, and SK-LU-1. In addition, the synthesized compounds were screened for in vitro antiparasitic activity against Leishmania braziliensis, Plasmodium falciparum, and Trypanosoma cruzi. Additionally, antibacterial activities were examined against two Gram-positive strains (S. aureus ATCC® 25923, L. monocytogenes ATCC® 19115) and two Gram-negative strains (E. coli ATCC® 25922, P. aeruginosa ATCC® 27583) using the microdilution method. The lanthanide complexes generally exhibited increased biological activity compared with the free Schiff base ligands. Interactions between the tested compounds and model membranes were examined using differential scanning calorimetry (DSC), and interactions with calf thymus DNA (CT-DNA) were investigated by ultraviolet (UV) absorption. Molecular docking studies were performed using leishmanin (1LML), cruzain (4PI3), P. falciparum alpha-tubulin (GenBank sequence CAA34101 [453 aa]), and S.aureus penicillin-binding protein 2a (PBP2A; 5M18) as the protein receptors. The results lead to the conclusion that the synthesized compounds exhibited a notable effect on model membranes imitating mammalian and bacterial membranes and rolled along DNA strands through groove interactions. Interactions between the compounds and studied receptors depended primarily on ligand structures in the molecular docking study.

Mix and match: templating chiral Schiff base ligands to suit the needs of the metal ion

2010 ◽  
Vol 39 (22) ◽  
pp. 5332 ◽  
Author(s):  
Edwin C. Constable ◽  
Guoqi Zhang ◽  
Catherine E. Housecroft ◽  
Jennifer A. Zampese
Keyword(s):  
Schiff Base ◽  
Metal Ion ◽  
Schiff Base Ligands ◽  
Chiral Schiff Base ◽  
Mix And Match

Molybdenum(vi) cis-dioxo complexes bearing sugar derived chiral Schiff-base ligands: synthesis, characterization, and catalytic applications

2003 ◽  
pp. 3736-3742 ◽  
Author(s):  
Jin Zhao ◽  
Xiangge Zhou ◽  
Ana M. Santos ◽  
Eberhardt Herdtweck ◽  
Carlos C. Romão ◽  
...  
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligands ◽  
Chiral Schiff Base ◽  
Catalytic Applications

Fluorescent lanthanide complexes of Schiff base ligands possessingN-aryl moiety: influence of chain length on crossover (calamitic to discotic) phase behaviour

2010 ◽  
Vol 37 (11) ◽  
pp. 1393-1410 ◽  
Author(s):  
Nandiraju V.S. Rao ◽  
Trirup D. Choudhury ◽  
Rahul Deb ◽  
Manoj K. Paul ◽  
Thatavarthi R. Rao ◽  
...  
Keyword(s):  
Schiff Base ◽  
Chain Length ◽  
Lanthanide Complexes ◽  
Phase Behaviour ◽  
Schiff Base Ligands

Racemization versus retention of chiral information during the formation of silicon and tin complexes with chiral Schiff base ligands

Polyhedron ◽  
2012 ◽  
Vol 47 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Gisela Warncke ◽  
Uwe Böhme ◽  
Betty Günther ◽  
Martin Kronstein
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligands ◽  
Tin Complexes ◽  
Chiral Schiff Base
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