Three-dimensional Mach-Zehnder interferometer in a microfluidic chip for spatially-resolved label-free detection

Lab on a Chip ◽  
2010 ◽  
Vol 10 (9) ◽  
pp. 1167 ◽  
Author(s):  
Andrea Crespi ◽  
Yu Gu ◽  
Bongkot Ngamsom ◽  
Hugo J. W. M. Hoekstra ◽  
Chaitanya Dongre ◽  
...  
Keyword(s):  
Microfluidic Chip ◽  
Three Dimensional ◽  
Zehnder Interferometer ◽  
Label Free ◽  
Spatially Resolved ◽  
Label Free Detection ◽  
Mach Zehnder Interferometer

scholarly journals A single-layer, planar, optofluidic Mach–Zehnder interferometer for label-free detection

Lab on a Chip ◽  
2011 ◽  
Vol 11 (10) ◽  
pp. 1795 ◽  
Author(s):  
Michael Ian Lapsley ◽  
I.-Kao Chiang ◽  
Yue Bing Zheng ◽  
Xiaoyun Ding ◽  
Xiaole Mao ◽  
...  
Keyword(s):  
Single Layer ◽  
Zehnder Interferometer ◽  
Label Free ◽  
Label Free Detection ◽  
Mach Zehnder Interferometer

scholarly journals Live E. coli bacteria label-free sensing using a microcavity in-line Mach-Zehnder interferometer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Monika Janik ◽  
Marcin Koba ◽  
Anna Celebańska ◽  
Wojtek J. Bock ◽  
Mateusz Śmietana
Keyword(s):  
Zehnder Interferometer ◽  
Label Free ◽  
E Coli ◽  
Mach Zehnder Interferometer

scholarly journals Polymer/glass hybrid DC-MZI thermal optical switch for 3D-integrated chips

RSC Advances ◽  
2019 ◽  
Vol 9 (19) ◽  
pp. 10651-10656 ◽  
Author(s):  
Yue Cao ◽  
Yun-Ji Yi ◽  
Bai-Zhu Lin ◽  
Yue Sun ◽  
Xin-Chi Che ◽  
...  
Keyword(s):  
Directional Coupler ◽  
Optical Switch ◽  
Three Dimensional ◽  
Zehnder Interferometer ◽  
Polymer Glass ◽  
Glass Waveguide ◽  
Mach Zehnder Interferometer

A directional coupler (DC) Mach–Zehnder interferometer (MZI) thermal optical switch based on a polymer and glass waveguide hybrid for three-dimensional (3D)-integrated chips is demonstrated.

scholarly journals An Innovative Cell Microincubator for Drug Discovery Based on 3D Silicon Structures

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Francesca Aredia ◽  
Francesca Carpignano ◽  
Salvatore Surdo ◽  
Giuseppe Barillaro ◽  
Giuliano Mazzini ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Tumor Cells ◽  
Three Dimensional ◽  
Label Free ◽  
Core Element ◽  
Great Ability ◽  
Label Free Detection ◽  
Ht1080 Cells ◽  
Power Radiation

We recently employed three-dimensional (3D) silicon microstructures (SMSs) consisting in arrays of 3 μm-thick silicon walls separated by 50 μm-deep, 5 μm-wide gaps, as microincubators for monitoring the biomechanical properties of tumor cells. They were here applied to investigate the in vitro behavior of HT1080 human fibrosarcoma cells driven to apoptosis by the chemotherapeutic drug Bleomycin. Our results, obtained by fluorescence microscopy, demonstrated that HT1080 cells exhibited a great ability to colonize the narrow gaps. Remarkably, HT1080 cells grown on 3D-SMS, when treated with the DNA damaging agent Bleomycin under conditions leading to apoptosis, tended to shrink, reducing their volume and mimicking the normal behavior of apoptotic cells, and were prone to leave the gaps. Finally, we performed label-free detection of cells adherent to the vertical silicon wall, inside the gap of 3D-SMS, by exploiting optical low coherence reflectometry using infrared, low power radiation. This kind of approach may become a new tool for increasing automation in the drug discovery area. Our results open new perspectives in view of future applications of the 3D-SMS as the core element of a lab-on-a-chip suitable for screening the effect of new molecules potentially able to kill tumor cells.

scholarly journals Low Power Consumption Mode Switch Based on Three-Dimensional Polymer Mach-Zehnder Interferometer

2020 ◽  
Vol 12 (3) ◽  
pp. 1-10
Author(s):  
Jiawen Lv ◽  
Tianhang Lian ◽  
Baizhu Lin ◽  
Yue Yang ◽  
Yue Cao ◽  
...  
Keyword(s):  
Power Consumption ◽  
Low Power ◽  
Three Dimensional ◽  
Zehnder Interferometer ◽  
Low Power Consumption ◽  
Mode Switch ◽  
Mach Zehnder Interferometer
Sign in / Sign up

Export Citation Format

Share Document