Dextran based pH-activated near-infrared fluorescence nanoprobe imaging the acidic compartments in cancer cells

2010 ◽  
Vol 46 (8) ◽  
pp. 1326 ◽  
Author(s):  
Cong Li ◽  
Kai Li ◽  
Huihui Yan ◽  
Guanghui Li ◽  
Jinsong Xia ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Fluorescence Nanoprobe ◽  
Acidic Compartments

scholarly journals Erythrocyte-derived nano-probes functionalized with antibodies for targeted near infrared fluorescence imaging of cancer cells

2016 ◽  
Vol 7 (4) ◽  
pp. 1311 ◽  
Author(s):  
Jenny T. Mac ◽  
Vicente Nuñez ◽  
Joshua M. Burns ◽  
Yadir A. Guerrero ◽  
Valentine I. Vullev ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

scholarly journals Selective imaging and cancer cell death via pH switchable near-infrared fluorescence and photothermal effects

2016 ◽  
Vol 7 (9) ◽  
pp. 5995-6005 ◽  
Author(s):  
Jingye Zhang ◽  
Zining Liu ◽  
Peng Lian ◽  
Jun Qian ◽  
Xinwei Li ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Ph Changes ◽  
Cancer Cell Death ◽  
Photothermal Effects

A theranostic probe is designed that specifically illuminates and photoablates cancer cells by sensing pH changes in the lysosomes and mitochondria.

Near-infrared fluorescence nanoprobe for enzyme-substrate system sensing and in vitro imaging

2016 ◽  
Vol 79 ◽  
pp. 922-929 ◽  
Author(s):  
Xu Yan ◽  
Tianyu Hu ◽  
Lei Wang ◽  
Lening Zhang ◽  
Xingguang Su
Keyword(s):  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Enzyme Substrate ◽  
Fluorescence Nanoprobe

scholarly journals Facile Construction of Near Infrared Fluorescence Nanoprobe with Amphiphilic Protein-Polymer Bioconjugate for Targeted Cell Imaging

2015 ◽  
Vol 7 (34) ◽  
pp. 18997-19005 ◽  
Author(s):  
Zhongyun Liu ◽  
Na Chen ◽  
Chunhong Dong ◽  
Wei Li ◽  
Weisheng Guo ◽  
...  
Keyword(s):  
Near Infrared ◽  
Cell Imaging ◽  
Near Infrared Fluorescence ◽  
Protein Polymer ◽  
Fluorescence Nanoprobe

pH-responsive near-infrared nanoprobe imaging metastases by sensing acidic microenvironment

RSC Advances ◽  
2014 ◽  
Vol 4 (98) ◽  
pp. 55548-55555 ◽  
Author(s):  
Zhan Si ◽  
Cuiyun Huang ◽  
Xihui Gao ◽  
Cong Li
Keyword(s):  
Tumor Microenvironment ◽  
Mouse Model ◽  
Near Infrared ◽  
Pulmonary Metastases ◽  
Ph Responsive ◽  
Near Infrared Fluorescence ◽  
Acidic Microenvironment ◽  
Fluorescence Nanoprobe

A pH responsive near-infrared fluorescence nanoprobe was developed and visualized pulmonary metastases in a mouse model with a volume as small as 0.5 mm3 by sensing the acidic tumor microenvironment.

scholarly journals A new H2S-specific near-infrared fluorescence-enhanced probe that can visualize the H2S level in colorectal cancer cells in mice

2017 ◽  
Vol 8 (4) ◽  
pp. 2776-2781 ◽  
Author(s):  
Kun Zhang ◽  
Jie Zhang ◽  
Zhen Xi ◽  
Lu-Yuan Li ◽  
Xiangxiang Gu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Real Time ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Real Time Imaging ◽  
Highly Sensitive ◽  
Colorectal Cancer Cells

A highly sensitive H2S-specific near-infrared fluorescence-enhanced probe was developed for real-time imaging of endogenous H2S in colorectal cancer cells (HCT116 and HT29) in mice.

pH-Activated Near-Infrared Fluorescence Nanoprobe Imaging Tumors by Sensing the Acidic Microenvironment

2010 ◽  
Vol 20 (14) ◽  
pp. 2222-2230 ◽  
Author(s):  
Cong Li ◽  
Jinsong Xia ◽  
Xunbin Wei ◽  
Huihui Yan ◽  
Zhan Si ◽  
...  
Keyword(s):  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Acidic Microenvironment ◽  
Fluorescence Nanoprobe

scholarly journals Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mi Hyeon Cho ◽  
Yan Li ◽  
Pui-Chi Lo ◽  
Hyeri Lee ◽  
Yongdoo Choi
Keyword(s):  
Endothelial Cells ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Oxygen Generation ◽  
Photodynamic Therapy Of Cancer ◽  
Near Infrared Fluorescence Imaging

Abstract In this study, a fucoidan-based theranostic nanogel (CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve activatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy (PDT) to induce the complete death of cancer cells. A CFN-gel has nanomolar affinity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention effect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar affinity for the vascular endothelial growth factor, it also provides a significant anti-tumor effect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high efficacy and specificity.

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