Prenylated indole derivatives from fungi: structure diversity, biological activities, biosynthesis and chemoenzymatic synthesis

2010 ◽  
Vol 27 (1) ◽  
pp. 57-78 ◽  
Author(s):  
Shu-Ming Li
Keyword(s):  
Biological Activities ◽  
Chemoenzymatic Synthesis ◽  
Indole Derivatives ◽  
Structure Diversity

Recent Developments on Synthesis of Indole Derivatives Through Green Approaches and Their Pharmaceutical Applications

2020 ◽  
Vol 24 (22) ◽  
pp. 2665-2693
Author(s):  
Dipayan Mondal ◽  
Pankaj Lal Kalar ◽  
Shivam Kori ◽  
Shovanlal Gayen ◽  
Kalpataru Das
Keyword(s):  
Biological Activities ◽  
Synthetic Methods ◽  
Pharmaceutical Chemistry ◽  
Indole Derivatives ◽  
Biological Studies ◽  
Recent Developments ◽  
Pharmaceutical Industries ◽  
Green Methodology ◽  
Conventional Methods ◽  
High Yields

Indole moiety is often found in different classes of pharmaceutically active molecules having various biological activities including anticancer, anti-viral, anti-psychotic, antihypertensive, anti-migraine, anti-arthritis and analgesic activities. Due to enormous applications of indole derivatives in pharmaceutical chemistry, a number of conventional synthetic methods as well as green methodology have been developed for their synthesis. Green methodology has many advantages including high yields, short reaction time, and inexpensive reagents, highly efficient and environmentally benign over conventional methods. Currently, the researchers in academia as well as in pharmaceutical industries have been developing various methods for the chemical synthesis of indole based compounds via green approaches to overcome the drawbacks of conventional methods. This review reflects the last ten years developments of the various greener methods for the synthesis of indole derivatives by using microwave, ionic liquids, water, ultrasound, nanocatalyst, green catalyst, multicomponent reaction and solvent-free reactions etc. (please see the scheme below). Furthermore, the applications of green chemistry towards developments of indole containing pharmaceuticals and their biological studies have been represented in this review.

scholarly journals Alkaloids Produced by Endophytic Fungi: A Review

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Yanyan Zhang ◽  
Ting Han ◽  
Qianliang Ming ◽  
Lingshang Wu ◽  
Khalid Rahman ◽  
...  
Keyword(s):  
Endophytic Fungi ◽  
Host Plants ◽  
Biological Activities ◽  
Biological Properties ◽  
Research Progress ◽  
Indole Derivatives ◽  
Anticancer Activities ◽  
Action Mechanisms ◽  
The Future ◽  
Potential Applications

In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed.

ChemInform Abstract: Synthesis of Some N-Substituted Indole Derivatives and Their Biological Activities.

ChemInform ◽  
2010 ◽  
Vol 23 (43) ◽  
pp. no-no
Author(s):  
H. EL-DIWANI ◽  
S. S. NAKKADY ◽  
O. H. HISHMAT ◽  
O. A. EL-SHABRAWY ◽  
S. S. MAHMOUD
Keyword(s):  
Biological Activities ◽  
Indole Derivatives

Synthesis of Schiff Base Indolyl-1,3,4-Oxadiazole, Thiazolidinone and Azetidinone as Efficient Antimicrobial, Antioxidant, Antituberculosis and Anticancer Agents

2019 ◽  
Vol 4 (2) ◽  
pp. 77-88
Author(s):  
Vaijinath A. Verma ◽  
Anand R. Saundane ◽  
Rajkumar S. Meti
Keyword(s):  
Schiff Base ◽  
Anticancer Agents ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Indole Derivatives ◽  
Tumor Cell Lines ◽  
Ferrous Ions ◽  
Antioxidant Power ◽  
Metal Chelating ◽  
H37rv Strain

The present investigation was under-taken to synthesize the Schiff base indole derivatives bearing of 1,3,4-oxadiazole thiazolidinone and azetidinone moieties. New series of 5-(5-substituted-3-phenyl-1H-indol-2-yl)-N-[(5-substituted-2-phenyl-1H-indol-3-yl)methylene]-1,3,4-oxadiazol-2-amines and screened their biological activities. Compound 4a showed excellent antibacterial and radical scavenging activities. Compound 5a revealed efficient to antifungal activity. In addition, compound 4a was found to be most active against H37Rv strain Mycobacterium tuberculosis. In case of anticancer activity methoxy compounds 4e and 6e against all the three tumor cell lines manifested remarkable cytotoxic activity. Compounds 4e, 5e and 6e have shown strong ferrous ions (Fe3+) reducing antioxidant power (FRAP) among the compounds screened. Compound 5b showed more potent of metal chelating on Fe2+ ions activity at all concentrations.

Synthesis and biological activities of novel indole derivatives as potent and selective PPARγ modulators

2010 ◽  
Vol 20 (4) ◽  
pp. 1399-1404 ◽  
Author(s):  
Yann Lamotte ◽  
Paul Martres ◽  
Nicolas Faucher ◽  
Alain Laroze ◽  
Didier Grillot ◽  
...  
Keyword(s):  
Biological Activities ◽  
Indole Derivatives

scholarly journals Synthesis and Cytotoxic Activity of Novel Indole Derivatives and Their in silico Screening on Spike Glycoprotein of SARS-CoV-2

2021 ◽  
Vol 8 ◽  
Author(s):  
Perumal Gobinath ◽  
Ponnusamy Packialakshmi ◽  
Daoud Ali ◽  
Saud Alarifi ◽  
Amal Alotaibi ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Anticancer Agents ◽  
In Silico ◽  
Normal Cell ◽  
Biological Activities ◽  
Research Work ◽  
Indole Derivatives ◽  
Spike Glycoprotein ◽  
Standard Drug

This work investigated the interaction of indole with SARS-CoV-2. Indole is widely used as a medical material owing to its astounding biological activities. Indole and its derivatives belong to a significant category of heterocyclic compounds that have been used as a crucial component for several syntheses of medicine. A straightforward one-pot three-component synthesis of indole, coupled with Mannich base derivatives 1a–1j, was synthesized without a catalyst. The products were confirmed by IR, 1H-NMR, 13C-NMR, mass spectra, and elemental analysis. The indole derivatives were tested for cytotoxic activity, using three cancer cell lines and normal cell lines of Human embryonic kidney cell (HEK293), liver cell (LO2), and lung cell (MRC5) by MTT assay using doxorubicin as the standard drug. The result of cytotoxicity indole compound 1c (HepG2, LC50−0.9 μm, MCF−7, LC50−0.55 μm, HeLa, LC50−0.50 μm) was found to have high activity compared with other compounds used for the same purpose. The synthesized derivatives have revealed their safety by exhibiting significantly less cytotoxicity against the normal cell line (HEK-293), (LO2), and (MRC5) with IC50 > 100 μg/ml. Besides, we report an in silico study with spike glycoprotein (SARS-CoV-2-S). The selective molecules of compound 1c exhibited the highest docking score −2.808 (kcal/mol) compared to other compounds. This research work was successful in synthesizing a few compounds with potential as anticancer agents. Furthermore, we have tried to emphasize the anticipated role of indole scaffolds in designing and discovering the much-awaited anti-SARS CoV-2 therapy by exploring the research articles depicting indole moieties as targeting SARS CoV-2 coronavirus.

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