Cooperativity in noncovalent interactions of biologically relevant molecules

2009 ◽  
Vol 11 (38) ◽  
pp. 8440 ◽  
Author(s):  
Jens Antony ◽  
Björn Brüske ◽  
Stefan Grimme
Keyword(s):  
Noncovalent Interactions ◽  
Biologically Relevant ◽  
Biologically Relevant Molecules

Multi-component reactions for the synthesis of biologically relevant molecules under environmentally benign conditions

2021 ◽  
Vol 25 ◽  
Author(s):  
Ranjay Shaw ◽  
Amr Elagamy ◽  
Ismail Althagafi ◽  
Akhilesh Kumar Srivastava ◽  
Ramendra Pratap
Keyword(s):  
Review Article ◽  
Toxic Waste ◽  
Environmentally Benign ◽  
Multicomponent Synthesis ◽  
Chemical Methods ◽  
Benign Condition ◽  
Biologically Relevant ◽  
Solvent Free Conditions ◽  
Ultrasound Assisted ◽  
Biologically Relevant Molecules

: Heterocycles are the most important skeleton as they are biologically and medicinally significant. Various chemical methods have been utilized for their synthesis. Among them, environmentally benign condition are most important as they produce less toxic waste and requires less toxic solvents and reagents. There is various literature available on sustainable and multicomponent synthetic. However, it is difficult for the researcher to keep up with the research. Therefore, a review article in the sustainable and multicomponent synthesis of heterocycle was highly required. Herein, we have compiled the literature related to multicomponent reaction under solvent-free conditions, ultrasound-assisted, water or ionic liquid mediated conditions.

scholarly journals Enantioselective organocatalysis in the synthesis of biologically relevant compounds

2016 ◽  
Author(s):  
Lukasz Albrecht
Keyword(s):  
Organic Chemistry ◽  
Amino Acids ◽  
Organic Molecules ◽  
Asymmetric Induction ◽  
Chiral Catalyst ◽  
Biologically Relevant ◽  
Enantioselective Reactions ◽  
Asymmetric Organocatalysis ◽  
Biologically Relevant Molecules ◽  
Operational Simplicity

The development of methods for the preparation of biologically relevant compounds in an enantiomerically enriched form constitutes one of the most significant tasks in the contemporary organic chemistry. In particular, enantioselective reactions where prochiral substrates are converted into enantiomerically enriched products in the presence of chiral catalyst are of great importance. Recently, asymmetric organocatalysis, where simple organic molecules are used as catalysts of various enantiodifferentiating reactions, has become a highly useful synthetic tool enabling for the efficient asymmetric induction based on diverse activation modes. Herein, we report our studies on organocatalytic, enantioselective strategies for the synthesis of biologically relevant molecules such as: quaternary α-amino acids and their isoelectronic analogs α-aminophosphonates, benzo[1,5]oxazocines, α-methylidene-δ-lactones, α-alkylidene-ketones, furfural derivatives, and benzothiophenes. The devised approaches utilize readily available chiral organocatalysts to control stereo-chemical reaction outcomes. Operational simplicity, efficiency and high enantio- and diastereoselectivities are the main benefits of the developed strategies.

scholarly journals An Efficient Electrochemical Sensor Driven by Hierarchical Hetero-Nanostructures Consisting of RuO2 Nanorods on WO3 Nanofibers for Detecting Biologically Relevant Molecules

Sensors ◽  
2019 ◽  
Vol 19 (15) ◽  
pp. 3295 ◽  
Author(s):  
Hyerim Lee ◽  
Yeomin Kim ◽  
Areum Yu ◽  
Dasol Jin ◽  
Ara Jo ◽  
...  
Keyword(s):  
Tungsten Trioxide ◽  
High Surface ◽  
High Surface Area ◽  
High Sensitivity ◽  
Annealing Process ◽  
Electrochemical Sensing ◽  
Biologically Relevant ◽  
Sensing Platform ◽  
Thermal Annealing Process ◽  
Biologically Relevant Molecules

By means of electrospinning with the thermal annealing process, we investigate a highly efficient sensing platform driven by a hierarchical hetero-nanostructure for the sensitive detection of biologically relevant molecules, consisting of single crystalline ruthenium dioxide nanorods (RuO2 NRs) directly grown on the surface of electrospun tungsten trioxide nanofibers (WO3 NFs). Electrochemical measurements reveal the enhanced electron transfer kinetics at the prepared RuO2 NRs-WO3 NFs hetero-nanostructures due to the incorporation of conductive RuO2 NRs nanostructures with a high surface area, resulting in improved relevant electrochemical sensing performances for detecting H2O2 and L-ascorbic acid with high sensitivity.

Relation between the NMR data and the pseudorotational free-energy profile for oxolane

2019 ◽  
Vol 18 (02) ◽  
pp. 1950012 ◽  
Author(s):  
Wojciech Plazinski ◽  
Karolina Gaweda ◽  
Anita Plazinska
Keyword(s):  
Free Energy ◽  
Quantitative Description ◽  
Coupling Constants ◽  
Biologically Relevant ◽  
Dna And Rna ◽  
Energy Profiles ◽  
Nmr Data ◽  
Biologically Relevant Molecules ◽  
Dynamics Simulations ◽  
Two State Model

The conformation of five-membered furanose rings is a crucial issue for the structural analysis of many biologically-relevant molecules, including DNA and RNA. Oxolane can be treated as a prototypical furanose, composed only of saturated unsubstituted ring. In spite of its structural simplicity, providing the accurate quantitative description of the oxolane conformational features remains a great challenge for both the experimental and theoretical techniques. Here we show the method of recovering the free-energy profiles describing the conformational equilibrium in the oxolane ring (i.e. pseudorotation) based on the experimentally-inferred NMR data ([Formula: see text] coupling constants). The results remain in agreement with the quantum-mechanical-based molecular dynamics simulations and emphasize the large contributions of all ring conformers, even those located at the free-energy barriers. This includes the significant populations of limiting 3T2/2T3 and OE/EO shapes. Our findings provide another example of a poor applicability of the two-state model, which is routinely applied to analyze the NMR data in terms of population of different ring conformers.

Synthesis of methoxy and hydroxy containing tetralones: versatile intermediates for the preparation of biologically relevant molecules

2003 ◽  
Vol 44 (21) ◽  
pp. 4145-4148 ◽  
Author(s):  
Anjan Ghatak ◽  
James M. Dorsey ◽  
Charles M. Garner ◽  
Kevin G. Pinney
Keyword(s):  
Biologically Relevant ◽  
Biologically Relevant Molecules
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