scholarly journals Main-chain organometallic polymers comprising redox-active iron(ii) centers connected by ditopic N-heterocyclic carbenes

2009 ◽  
pp. 7168 ◽  
Author(s):  
Laszlo Mercs ◽  
Antonia Neels ◽  
Helen Stoeckli-Evans ◽  
Martin Albrecht
Keyword(s):  
Main Chain ◽  
Heterocyclic Carbenes ◽  
Organometallic Polymers ◽  
Active Iron ◽  
Redox Active

scholarly journals Molecular complexes and main-chain organometallic polymers based on Janus bis(carbenes) fused to metalloporphyrins

2020 ◽  
Vol 49 (21) ◽  
pp. 7005-7014
Author(s):  
Jean-François Longevial ◽  
Mamadou Lo ◽  
Aurélien Lebrun ◽  
Danielle Laurencin ◽  
Sébastien Clément ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Main Chain ◽  
Molecular Complexes ◽  
Heterocyclic Carbenes ◽  
Organometallic Polymers ◽  
Bridging Ligands ◽  
Porphyrin Core

Janus bis(N-heterocyclic carbenes) composed of a porphyrin core with two N-heterocyclic carbene (NHC) heads fused to opposite pyrroles were used as bridging ligands for the preparation of metal complexes.

In vitro study on the effects of iron sucrose, ferric gluconate and iron dextran on redox-active iron and oxidative stress

2011 ◽  
Vol 60 (07) ◽  
pp. 459-465
Author(s):  
Brigitte Sturm ◽  
Hannes Steinkellner ◽  
Nina Ternes ◽  
Hans Goldenberg ◽  
Barbara Scheiber-Mojdehkar
Keyword(s):  
Oxidative Stress ◽  
In Vitro Study ◽  
Iron Sucrose ◽  
Vitro Study ◽  
Iron Dextran ◽  
Active Iron ◽  
Redox Active ◽  
And Oxidative Stress

Abstract T P351: Unbound Iron and Ceruloplasmin Levels in Cerebrospinal Fluid Are Associated with Development of Deep Cerebral Infarcts Following Subarachnoid Hemorrhage

Stroke ◽  
2014 ◽  
Vol 45 (suppl_1) ◽  
Author(s):  
Lauren Koffman ◽  
Gabor Toth ◽  
M. Shazam Hussain ◽  
Magdy Selim ◽  
Peter Rasmussen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Hemorrhage ◽  
Cerebral Infarcts ◽  
Active Iron ◽  
Redox Active ◽  
Wilcoxon Rank Sum Test ◽  
Radiological Data ◽  
Experimental Subarachnoid Hemorrhage ◽  
Preliminary Study ◽  
Iron Redox

Introduction: Iron-dependent formation of reactive oxygen species has been implicated in the development of vasospasm (VSP) and neuronal injury following experimental subarachnoid hemorrhage (SAH). We report the association between unbound (“free”) iron in CSF of SAH patients and the risk of angiographic vasospasm and cerebral infarcts (CI) on neuroimaging from a recently completed pilot study. Methods: Samples of cerebrospinal fluid (CSF) were obtained on days 1, 3, and 5. A fluorometric assay that relies on an oxidation sensitive probe was used to measure redox active iron (REDOX-Fe). Ceruloplasmin (Cp) concentration and levels of malondialdehyde (MDA), a marker of lipid peroxidation were also measured. We prospectively collected and recorded demographic, clinical, and radiological data. Logistic regression and Wilcoxon Rank Sum test were used. Results: Five of 12 patients developed angiographic VSP (41.6%) and eight developed CI (66.6%). Mean REDOX-Fe was higher in patients with CI (3.96 ± 0.97 Vs. 2.77 ± 0.87 mcg/dl, p 0.07), particularly in patients with deep-seated strokes (4.56 ± 0.67 Vs. 3.35 ± 0.89, p 0.03). Levels of Cp at day 3 were lower in patients with deep strokes (34,092 ± 23,780 Vs. 86,045 ± 34,752 ng/ml, p 0.03). A trend towards higher REDOX-Fe on day 3 in patients who developed VSP (4.52 ± 1.16 Vs. 2.96 ± 0.71, p 0.07), and lower Cp levels on day 5 (45,033 ± 29,079 Vs. 63,044 ± 24,821, p 0.1) was found. Levels of MDA were higher in patients who developed CI (10.36 ± 4.36 Vs. 5.9 ± 4.2 nmol, p 0.08). Conclusions: In this preliminary study we found higher concentrations of redox active iron in CSF of SAH patients who develop deep-seated CI on neuroimaging. Evidence of increased oxidative damage correlated with development of CI. A possible association between non-protein bound iron and angiographic VSP is suggested as well. Ceruloplasmin may exert a protective effect in this setting. Further studies are needed to validate these findings.

199 Red Cell Rejuvenation Targets Inflammatory Microparticles, free Haemoglobin and Redox Active Iron: Key Mediators of Transfusion Related Acute Lung Injury in Cardiac Surgery

Heart ◽  
2015 ◽  
Vol 101 (Suppl 4) ◽  
pp. A110.2-A110
Author(s):  
Saqib Qureshi ◽  
Nishith Patel ◽  
Marcin Wozniak ◽  
Rebecca Cardigan ◽  
Gavin Murphy
Keyword(s):  
Cardiac Surgery ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Red Cell ◽  
Active Iron ◽  
Redox Active ◽  
Free Haemoglobin

Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury

1994 ◽  
Vol 266 (2) ◽  
pp. H384-H392 ◽  
Author(s):  
E. J. Lesnefsky ◽  
J. Ye
Keyword(s):  
Myocardial Injury ◽  
Lipid Peroxide ◽  
Oxidative Injury ◽  
Early Reperfusion ◽  
Excess Iron ◽  
Active Iron ◽  
Direct Demonstration ◽  
Redox Active ◽  
Catalyzed Reactions ◽  
Developed Pressure

Although previous studies using iron chelators suggest that iron-catalyzed reactions exacerbate myocardial injury, a direct demonstration of the timing, sites, and mechanisms of iron-mediated damage during reperfusion has been lacking. Catalytic doses of redox-active iron react with exogenously administered oxygen radical-generating systems to exacerbate myocardial injury. In an analogous manner, catalytic doses (5 microM) of excess iron present during early reperfusion should augment oxidative injury, if the redox-active iron is present in the same compartment as both the oxygen radicals generated during reperfusion as well as the critical biochemical targets of oxidative injury. We determined whether catalytic doses of iron given during early reperfusion could exacerbate myocardial injury and whether iron-catalyzed injury required intra- or extracellular iron. Buffer-perfused rabbit hearts underwent 30 min of 37 degrees C global ischemia and 30 min of reperfusion. Iron (5 microM), attached to ligands that either restrict iron to the extracellular space (ADP) or facilitate the entry of iron into myocytes (omadine, tropolone), was infused during the last 3 min of ischemia and the first 4 min of reperfusion. Recovery of developed pressure was decreased (P < 0.05) in omadine-iron and tropolone-iron compared with ADP-iron and noniron hearts treated with ligands alone. Tissue lipid peroxide levels, an index of oxidative injury, were increased (P < 0.05) by omadine-iron and tropolone-iron, but not ADP-iron. The oxidative damage caused by omadine-iron was blocked by pretreatment with dimethylthiourea, a cell-permeable scavenger of the hydroxyl radical.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Neuromelanin associated redox-active iron is increased in the substantia nigra of patients with Parkinson's disease

2003 ◽  
Vol 86 (5) ◽  
pp. 1142-1148 ◽  
Author(s):  
Baptiste A. Faucheux ◽  
Marie-Elise Martin ◽  
Carole Beaumont ◽  
Jean-Jacques Hauw ◽  
Yves Agid ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Active Iron ◽  
Redox Active

Spherical core–shell magnetic particles constructed by main-chain palladium N-heterocyclic carbenes

Nanoscale ◽  
2015 ◽  
Vol 7 (8) ◽  
pp. 3532-3538 ◽  
Author(s):  
Huaixia Zhao ◽  
Liuyi Li ◽  
Jinyun Wang ◽  
Ruihu Wang
Keyword(s):  
Magnetic Particles ◽  
Main Chain ◽  
Heterocyclic Carbenes ◽  
Core Shell ◽  
Spherical Core

The spherical core–shell magnetic particles were presented by the encapsulation of Fe3O4nanoparticles inside the main-chain palladium N-heterocyclic carbene matrices.

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