scholarly journals Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells

2009 ◽  
Vol 19 (32) ◽  
pp. 5737 ◽  
Author(s):  
Chih-Pin Tsai ◽  
Chao-Yu Chen ◽  
Yann Hung ◽  
Fu-Hsiung Chang ◽  
Chung-Yuan Mou
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Selective Targeting

scholarly journals Large Pore Mesoporous Silica and Organosilica Nanoparticles for Pepstatin A Delivery in Breast Cancer Cells

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 332 ◽  
Author(s):  
Saher Rahmani ◽  
Jelena Budimir ◽  
Mylene Sejalon ◽  
Morgane Daurat ◽  
Dina Aggad ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Cathepsin D ◽  
Breast Cancer Cells ◽  
Potent Inhibitor ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Pepstatin A

(1) Background: Nanomedicine has recently emerged as a new area of research, particularly to fight cancer. In this field, we were interested in the vectorization of pepstatin A, a peptide which does not cross cell membranes, but which is a potent inhibitor of cathepsin D, an aspartic protease particularly overexpressed in breast cancer. (2) Methods: We studied two kinds of nanoparticles. For pepstatin A delivery, mesoporous silica nanoparticles with large pores (LPMSNs) and hollow organosilica nanoparticles (HOSNPs) obtained through the sol–gel procedure were used. The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. (3) Results: LPMSNs were monodisperse with 100 nm diameter. HOSNPs were more polydisperse with diameters below 100 nm. Good loading capacities were obtained for both types of nanoparticles. The nanoparticles were endocytosed in cancer cells, and HOSNPs led to the best results for cancer cell killing. (4) Conclusions: Mesoporous silica-based nanoparticles with large pores or cavities are promising for nanomedicine applications with peptides.

Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells

2016 ◽  
Vol 1860 (10) ◽  
pp. 2065-2075 ◽  
Author(s):  
Abhijit Sarkar ◽  
Shatadal Ghosh ◽  
Sayantani Chowdhury ◽  
Bhawna Pandey ◽  
Parames C. Sil
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Mesoporous Silica Nanoparticles

scholarly journals Targeting Innate Immunity with dsRNA-Conjugated Mesoporous Silica Nanoparticles Promotes Antitumor Effects on Breast Cancer Cells

2016 ◽  
Vol 22 (5) ◽  
pp. 1582-1586 ◽  
Author(s):  
Amelia Ultimo ◽  
Cristina Giménez ◽  
Pavel Bartovsky ◽  
Elena Aznar ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Innate Immunity ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Antitumor Effects

MUC1 aptamer-conjugated mesoporous silica nanoparticles effectively target breast cancer cells

2017 ◽  
Vol 44 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Mohammad Yahya Hanafi-Bojd ◽  
Seyedeh Alia Moosavian Kalat ◽  
Seyed Mohammad Taghdisi ◽  
Legha Ansari ◽  
Khalil Abnous ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Muc1 Aptamer
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