Metal trafficking: from maintaining the metal homeostasis to future drug design

Metallomics ◽  
2009 ◽  
Vol 1 (4) ◽  
pp. 292 ◽  
Author(s):  
Lalla Aicha Ba ◽  
Mandy Doering ◽  
Torsten Burkholz ◽  
Claus Jacob
Keyword(s):  
Drug Design ◽  
Metal Homeostasis ◽  
Metal Trafficking ◽  
Future Drug

Mannich Bases: Centrality in Cytotoxic Drug Design

2021 ◽  
Vol 18 ◽  
Author(s):  
Neha V. Bhilare ◽  
Vinayak S. Marulkar ◽  
Pramodkumar J. Shirote ◽  
Shailaja A. Dombe ◽  
Vilas J. Pise ◽  
...  
Keyword(s):  
Drug Design ◽  
Drug Development ◽  
Cell Lines ◽  
Mannich Bases ◽  
Cytotoxic Agents ◽  
Structure Activity ◽  
Anti Cancer ◽  
Methods Of Synthesis ◽  
Future Drug ◽  
Clinical Conditions

: Mannich bases identified by Professor Carl Mannich have been the most extensively explored scaffolds for more than 100 years now. The versatile biological roles that they play have promoted their applications in many clinical conditions. The present review highlights the application of Mannich bases as cytotoxic agents, categorizing them into synthetic, semisynthetic and prodrugs classes and gives an exhaustive account of the work reported in the last two decades. The methods of synthesis of these cytotoxic agents, their anti-cancer potential in various cell lines and promising leads for future drug development have also been discussed. Structure-activity relationships along with the targets on which these cytotoxic Mannich bases act have been included as well.

The impact of epigenomics on future drug design and new therapies

2011 ◽  
Vol 16 (13-14) ◽  
pp. 626-635 ◽  
Author(s):  
Christopher A. Hamm ◽  
Fabricio F. Costa
Keyword(s):  
Drug Design ◽  
New Therapies ◽  
Future Drug ◽  
The Impact

Sequence diversity and ligand-induced structural rearrangements of viper hyaluronidase

2016 ◽  
Vol 12 (4) ◽  
pp. 1128-1138 ◽  
Author(s):  
A. Christian Bharathi ◽  
Pradeep Kumar Yadav ◽  
B. Syed Ibrahim
Keyword(s):  
Drug Design ◽  
Cancer Treatment ◽  
Drug Targets ◽  
Structural Changes ◽  
Sequence Diversity ◽  
Structural Rearrangements ◽  
Structure Based Drug Design ◽  
Future Drug ◽  
Insight Into

The study focuses on ligand-induced structural changes of viper hyaluronidase and also provides insight into structure-based drug design for eukaryotic hyaluronidases, which could be future drug targets in cancer treatment, and venom spreading.

scholarly journals The structure of the human mitochondrial ribosome

Science ◽  
2015 ◽  
Vol 348 (6230) ◽  
pp. 95-98 ◽  
Author(s):  
Alexey Amunts ◽  
Alan Brown ◽  
Jaan Toots ◽  
Sjors H. W. Scheres ◽  
V. Ramakrishnan
Keyword(s):  
Drug Design ◽  
Oxidative Phosphorylation ◽  
Ribosomal Rna ◽  
Single Particle ◽  
Small Subunit ◽  
Rna Molecules ◽  
Essential Proteins ◽  
Mitochondrial Ribosome ◽  
Future Drug ◽  
Guanosine Triphosphatase

The highly divergent ribosomes of human mitochondria (mitoribosomes) synthesize 13 essential proteins of oxidative phosphorylation complexes. We have determined the structure of the intact mitoribosome to 3.5 angstrom resolution by means of single-particle electron cryogenic microscopy. It reveals 80 extensively interconnected proteins, 36 of which are specific to mitochondria, and three ribosomal RNA molecules. The head domain of the small subunit, particularly the messenger (mRNA) channel, is highly remodeled. Many intersubunit bridges are specific to the mitoribosome, which adopts conformations involving ratcheting or rolling of the small subunit that are distinct from those seen in bacteria or eukaryotes. An intrinsic guanosine triphosphatase mediates a contact between the head and central protuberance. The structure provides a reference for analysis of mutations that cause severe pathologies and for future drug design.

scholarly journals The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders

2021 ◽  
Vol 22 (9) ◽  
pp. 4307
Author(s):  
Kinga Sałaciak ◽  
Aleksandra Koszałka ◽  
Elżbieta Żmudzka ◽  
Karolina Pytka
Keyword(s):  
Drug Design ◽  
Therapeutic Targets ◽  
Neuropsychiatric Disorders ◽  
Cellular Functions ◽  
Calcium Calmodulin Dependent ◽  
Regulatory Processes ◽  
Neuropsychiatric Diseases ◽  
Future Drug ◽  
Structure And Functions

CaMKII and CaMKIV are calcium/calmodulin-dependent kinases playing a rudimentary role in many regulatory processes in the organism. These kinases attract increasing interest due to their involvement primarily in memory and plasticity and various cellular functions. Although CaMKII and CaMKIV are mostly recognized as the important cogs in a memory machine, little is known about their effect on mood and role in neuropsychiatric diseases etiology. Here, we aimed to review the structure and functions of CaMKII and CaMKIV, as well as how these kinases modulate the animals’ behavior to promote antidepressant-like, anxiolytic-like, and procognitive effects. The review will help in the understanding of the roles of the above kinases in the selected neurodegenerative and neuropsychiatric disorders, and this knowledge can be used in future drug design.

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