scholarly journals A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging

2009 ◽  
Vol 19 (35) ◽  
pp. 6367 ◽  
Author(s):  
Gang Huang ◽  
Chunfu Zhang ◽  
Shunzi Li ◽  
Chalermchai Khemtong ◽  
Su-Geun Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Surface Modification ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cancer Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Novel Strategy

Folate–PEG–superparamagnetic iron oxide nanoparticles for lung cancer imaging

2012 ◽  
Vol 8 (8) ◽  
pp. 3005-3013 ◽  
Author(s):  
Mi-Kyong Yoo ◽  
In-Kyu Park ◽  
Hwang-Tae Lim ◽  
Sang-Joon Lee ◽  
Hu-Lin Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cancer Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

scholarly journals Investigation of Combination Effect Between 6 MV X Ray Radiation and Polyglycerol Coated Superparamagnetic Iron Oxide Nanoparticles on U87-MG Cancer Cells

2018 ◽  
Author(s):  
S Jafari ◽  
M Cheki ◽  
M B Tavakoli ◽  
A Zarrabi ◽  
K Ghazikhanlu Sani ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
X Rays ◽  
Dose Verification ◽  
Superparamagnetic Behaviour ◽  
Mean Size ◽  
Novel Strategy

Background: Radiosensitization using nanoparticles is proposed as a novel strategy for treatment of different cancers. Superparamagnetic iron oxide nanoparticles (SPIONs) have been reported to enhance effects of radiotherapy in several researches. The objective of this research is to investigate the radiosensitization properties of polyglycerol coated SPIONs (PG-SPIONs) on U87-MG cancer cells.Material and Methods: Polyglycerol coated SPIONs were synthesized by thermal decomposition method and characterized by FTIR, TEM and VSM analysis. Cellular uptake of nanoparticles by cells was examined via AAS. Cytotoxicity and radiosensitization of nanoparticles in combination with radiation were evaluated by MTT and colony assay, respectively.Results: Mean size of nanoparticles was 17.9±2.85 nm. FTIR verified SPIONs coating by Polyglycerol and VSM showed that they have superparamagnetic behaviour. Viability significantly (P < 0.001) decreased at concentrations above 100µg/ml for SPIONs but not for PG-SPIONs (P > 0.05). Dose verification results by TLD for doses of 2 and 4 Gy were 2±0/19 and 4±0/12 Gy respectively. The combination index for all situations was less than 1 and the effect is antagonism.Conclusion: However, PG-SPIONs combination with 6 MV X rays reduced survival of U87-MG cells compared to radiation alone but the effect is antagonism.

Drug‐Loaded Superparamagnetic Iron Oxide Nanoparticles for Combined Cancer Imaging and Therapy In Vivo

2008 ◽  
Vol 120 (29) ◽  
pp. 5442-5445 ◽  
Author(s):  
Mi Kyung Yu ◽  
Yong Yeon Jeong ◽  
Jinho Park ◽  
Sangjin Park ◽  
Jin Woong Kim ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cancer Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles
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