ps-TRIR covers all the bases – recent advances in the use of transient IR for the detection of short-lived species in nucleic acids

The Analyst ◽  
2009 ◽  
Vol 134 (7) ◽  
pp. 1265 ◽  
Author(s):  
Michael Towrie ◽  
Gerard W. Doorley ◽  
Michael W. George ◽  
Anthony W. Parker ◽  
Susan J. Quinn ◽  
...  
2012 ◽  
Vol 19 (6) ◽  
pp. 462-468 ◽  
Author(s):  
Nancy Bo Yin Tsui ◽  
Yuk Ming Dennis Lo

2018 ◽  
Vol 6 (3) ◽  
pp. 438-451 ◽  
Author(s):  
Yuwei Zhu ◽  
Zhiwei Huang

Abstract Clustered regularly interspaced short palindromic repeats (CRISPR) and accompanying CRISPR-associated (Cas) proteins provide RNA-guided adaptive immunity for prokaryotes to defend themselves against viruses. The CRISPR-Cas systems have attracted much attention in recent years for their power in aiding the development of genome editing tools. Based on the composition of the CRISPR RNA-effector complex, the CRISPR-Cas systems can be divided into two classes and six types. In this review, we summarize recent advances in the structural biology of the CRISPR-Cas-mediated genome editing tools, which helps us to understand the mechanism of how the guide RNAs assemble with diverse Cas proteins to cleave target nucleic acids.


2014 ◽  
Vol 2 (46) ◽  
pp. 8069-8084 ◽  
Author(s):  
Amit Singh ◽  
Meghna Talekar ◽  
Thanh-Huyen Tran ◽  
Abishek Samanta ◽  
Ravi Sundaram ◽  
...  

This update summarizes the recent advances in combinatorial design of polymeric material for developing multifunctional nanovectors to deliver nucleic acids and chemodrugs for cancer therapy.


2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Jin Lin ◽  
Jing Li ◽  
Bo Huang ◽  
Jing Liu ◽  
Xin Chen ◽  
...  

Exosomes are 30–120 nm endocytic membrane-derived vesicles that participate in cell-to-cell communication and protein and RNA delivery. Exosomes harbor a variety of proteins, nucleic acids, and lipids and are present in many and perhaps all bodily fluids. A significant body of literature has demonstrated that molecular constituents of exosomes, especially exosomal proteins and microRNAs (miRNAs), hold great promise as novel biomarkers for clinical diagnosis. In this minireview, we summarize recent advances in the research of exosomal biomarkers and their potential application in clinical diagnostics. We also provide a brief overview of the formation, function, and isolation of exosomes.


2019 ◽  
Vol 114 ◽  
pp. 56-68 ◽  
Author(s):  
Arezoo Saadati ◽  
Soodabeh Hassanpour ◽  
Miguel de la Guardia ◽  
Jafar Mosafer ◽  
Mahmoud Hashemzaei ◽  
...  

2006 ◽  
Vol 6 (2) ◽  
pp. 121-145 ◽  
Author(s):  
C. Romero-Lopez ◽  
F. Sanchez-Luque ◽  
A. Berzal-Herranz

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