Protonation activates anion binding and alters binding selectivity in new inherently fluorescent 2,6-bis(2-anilinoethynyl)pyridine bisureas

2009 ◽  
pp. 2520 ◽  
Author(s):  
Calden N. Carroll ◽  
Orion B. Berryman ◽  
Charles A. Johnson ◽  
Lev N. Zakharov ◽  
Michael M. Haley ◽  
...  
Keyword(s):  
Anion Binding ◽  
Binding Selectivity

A Novel Ditopic Receptor and Reversal of Anion Binding Selectivity in the Presence and Absence of Bound Cation

2003 ◽  
Vol 5 (26) ◽  
pp. 4971-4974 ◽  
Author(s):  
Gamolwan Tumcharern ◽  
Thawatchai Tuntulani ◽  
Simon J. Coles ◽  
Michael B. Hursthouse ◽  
Jeremy D. Kilburn
Keyword(s):  
Anion Binding ◽  
Binding Selectivity ◽  
Ditopic Receptor ◽  
Presence And Absence

ChemInform Abstract: Protonation Activates Anion Binding and Alters Binding Selectivity in New Inherently Fluorescent 2,6-Bis(2-anilinoethynyl)pyridine Bisureas.

ChemInform ◽  
2009 ◽  
Vol 40 (35) ◽  
Author(s):  
Calden N. Carroll ◽  
Orion B. Berryman ◽  
Charles A. II Johnson ◽  
Lev N. Zakharov ◽  
Michael M. Haley ◽  
...  
Keyword(s):  
Anion Binding ◽  
Binding Selectivity

The Ability of Thrombin Inhibitors to Reduce the Thrombin Activity Generated in Plasma on Extrinsic and Intrinsic Activation

1997 ◽  
Vol 77 (03) ◽  
pp. 498-503 ◽  
Author(s):  
D Prasa ◽  
L Svendsen ◽  
J Stürzebecher
Keyword(s):  
Active Site ◽  
Thrombin Generation ◽  
Anion Binding ◽  
Thrombin Inhibitors ◽  
Coagulation System ◽  
Thrombin Activity ◽  
Continuous Registration ◽  
High Concentrations ◽  
20 Nm ◽  
Generation Test

SummaryIn a thrombin generation test with continuous registration of thrombin activity in plasma we studied the ability of a variety of thrombin inhibitors of different type and mechanism of action to influence the activity of thrombin after activation of the coagulation system. Depending on the inhibitor, the peak of thrombin activity is delayed and/or reduced.By blocking the active site of generated thrombin inhibitors cause a concentration dependent reduction of the thrombin peak and inhibit feed-back reactions of thrombin resulting in a delay of thrombin generation. Highly potent synthetic active-site directed inhibitors (Ki ≤ 20 nM) reduce the thrombin activity formed in plasma after extrinsic or intrinsic activation with the same efficiency (IC50 0.1 - 0.6 μM) as hirudin. The delay and reduction of thrombin generation by inhibitors of the anion-binding exosite 1 of thrombin is only attributed to an inhibition of feed-back reactions of thrombin. For a 50% reduction of thrombin activity in plasma by this type of inhibitors relatively high concentrations were determined.

Cambiarenes: Single-Step Synthesis and Anion Binding of a Clip- Shaped Macrocycle with a Redox-Active Core

2019 ◽  
Author(s):  
Riley J. Petersen ◽  
Brett J. Rozeboom ◽  
Shalisa Oburn ◽  
Nolan Blythe ◽  
Tanner Rathje ◽  
...  
Keyword(s):  
Electron Density ◽  
Single Step ◽  
Anion Binding ◽  
Host Molecule ◽  
Selective Binding ◽  
The Core ◽  
Redox Active ◽  
Active Core ◽  
Guest Binding

<div>We report the synthesis of a novel macrocyclic host molecule that forms in a single step from commercially available starting materials. The core of the macrocycle backbone possesses two quinone rings and, thus, is redox-active. Host-guest binding involving the clip-shaped cavity indicates selective binding of pyridine <i>N</i>-oxides based of the electron density of and steric bulk of the anionic oxygen.</div>

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