Intermolecular forces in lipid monolayers. Two-dimensional virial coefficients for pentadecanoic acid from micromanometry on spread monolayers at the air/water interface

2009 ◽  
Vol 11 (25) ◽  
pp. 5028 ◽  
Author(s):  
Norman R. Pallas ◽  
Brian A. Pethica
1999 ◽  
Vol 196 (2-4) ◽  
pp. 456-470 ◽  
Author(s):  
Alain Brisson ◽  
Wilma Bergsma-Schutter ◽  
Frank Oling ◽  
Olivier Lambert ◽  
Ilya Reviakine

2001 ◽  
Vol 166 (1) ◽  
pp. 1-12 ◽  
Author(s):  
C.W. Frank ◽  
C.A. Naumann ◽  
W. Knoll ◽  
C.F. Brooks ◽  
G.G. Fuller

2009 ◽  
Vol 7 (suppl_1) ◽  
Author(s):  
Rakesh Kumar Harishchandra ◽  
Mohammed Saleem ◽  
Hans-Joachim Galla

One of the most important functions of the lung surfactant monolayer is to form the first line of defence against inhaled aerosols such as nanoparticles (NPs), which remains largely unexplored. We report here, for the first time, the interaction of polyorganosiloxane NPs (AmorSil20: 22 nm in diameter) with lipid monolayers characteristic of alveolar surfactant. To enable a better understanding, the current knowledge about an established model surface film that mimics the surface properties of the lung is reviewed and major results originating from our group are summarized. The pure lipid components dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylglycerol have been used to study the biophysical behaviour of their monolayer films spread at the air–water interface in the presence of NPs. Film balance measurements combined with video-enhanced fluorescence microscopy have been used to investigate the formation of domain structures and the changes in the surface pattern induced by NPs. We are able to show that NPs are incorporated into lipid monolayers with a clear preference for defect structures at the fluid–crystalline interface leading to a considerable monolayer expansion and fluidization. NPs remain at the air–water interface probably by coating themselves with lipids in a self-assembly process, thereby exhibiting hydrophobic surface properties. We also show that the domain structure in lipid layers containing surfactant protein C, which is potentially responsible for the proper functioning of surfactant material, is considerably affected by NPs.


1997 ◽  
Vol 119 (9) ◽  
pp. 2341-2342 ◽  
Author(s):  
Masatsugu Shimomura ◽  
Fumio Nakamura ◽  
Kuniharu Ijiro ◽  
Hirotaka Taketsuna ◽  
Masaru Tanaka ◽  
...  

2002 ◽  
Vol 376 (1) ◽  
pp. 383-388
Author(s):  
Jeffrey T. Culp ◽  
A. NICOLE Morgan ◽  
Mark W. Meisel ◽  
Daniel R. Talham

2014 ◽  
Vol 550 ◽  
pp. 621-629 ◽  
Author(s):  
Rute I.S. Romão ◽  
José M.G. Martinho ◽  
Amélia M.P.S. Gonçalves da Silva

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