A lysine walk to high relaxivity collagen-targeted MRI contrast agents

2009 ◽  
pp. 430-432 ◽  
Author(s):  
Peter Caravan ◽  
Biplab Das ◽  
Qing Deng ◽  
Stéphane Dumas ◽  
Vincent Jacques ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
High Relaxivity ◽  
Targeted Mri

scholarly journals Trivalent Gd-DOTA reagents for modification of proteins

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 96194-96200 ◽  
Author(s):  
Martin J. Fisher ◽  
Daniel J. Williamson ◽  
George M. Burslem ◽  
Jeffrey P. Plante ◽  
Iain W. Manfield ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
Target Proteins ◽  
Targeted Mri ◽  
High Payload ◽  
Novel Protein

The development of novel protein-targeted MRI contrast agents crucially depends on the ability to derivatise suitable targeting moieties with a high payload of relaxation enhancer without losing affinity for the target proteins.

ChemInform Abstract: High-Relaxivity MRI Contrast Agents: Where Coordination Chemistry Meets Medical Imaging

ChemInform ◽  
2009 ◽  
Vol 40 (3) ◽  
Author(s):  
Eric J. Werner ◽  
Ankona Datta ◽  
Christoph J. Jocher ◽  
Kenneth N. Raymond
Keyword(s):  
Coordination Chemistry ◽  
Medical Imaging ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
High Relaxivity

scholarly journals Nano-assemblies of cationic mPEG brush block copolymers with gadolinium polyoxotungstate [Gd(W5O18)2]9− form stable, high relaxivity MRI contrast agents

Nanoscale ◽  
2018 ◽  
Vol 10 (15) ◽  
pp. 7270-7280 ◽  
Author(s):  
Joanne Ly ◽  
Yuhuan Li ◽  
Mai N. Vu ◽  
Bradford A. Moffat ◽  
Kevin S. Jack ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Good Stability ◽  
Mri Contrast ◽  
High Relaxivity

Nano-assemblies of gadolinium polyoxotungstate and cationic mPEG brush block copolymer demonstrated good stability and enhanced relaxivity at physiological pH.

scholarly journals A Photocleavable Contrast Agent for Light-Responsive MRI

2020 ◽  
Vol 13 (10) ◽  
pp. 296
Author(s):  
Friederike Reeßing ◽  
Sèvrin E. M. Huijsse ◽  
Rudi A. J. O. Dierckx ◽  
Ben L. Feringa ◽  
Ronald J.H. Borra ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Whole Body ◽  
Spatiotemporal Resolution ◽  
Mri Contrast ◽  
High Relaxivity ◽  
Vis Spectroscopy ◽  
Clinical Mri

Thanks to its innocuousness and high spatiotemporal resolution, light is used in several established and emerging applications in biomedicine. Among them is the modulation of magnetic resonance imaging (MRI) contrast agents’ relaxivity with the aim to increase the sensitivity, selectivity and amount of functional information obtained from this outstanding whole-body medical imaging technique. This approach requires the development of molecular contrast agents that show high relaxivity and strongly pronounced photo-responsiveness. To this end, we report here the design and synthesis of a light-activated MRI contrast agent, together with its evaluation using UV–vis spectroscopy, Fast Field Cycling (FFC) relaxometry and relaxometric measurements on clinical MRI scanners. The high relaxivity of the reported agent changes substantially upon irradiation with light, showing a 17% decrease in relaxivity at 0.23T upon irradiation with λ = 400 nm (violet) light for 60 min. On clinical MRI scanners (1.5T and 3.0T), irradiation leads to a decrease in relaxivity of 9% and 19% after 3 and 60 min, respectively. The molecular design presents an important blueprint for the development of light-activatable MRI contrast agents.

Supramolecular aggregates from polyacrylates and Gd(iii)-containing cationic surfactants as high-relaxivity MRI contrast agents

2015 ◽  
Vol 6 (9) ◽  
pp. 1521-1526 ◽  
Author(s):  
Yingying Chen ◽  
Qin Zhu ◽  
Yu Tian ◽  
Weijun Tang ◽  
Fei Pan ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Cationic Surfactants ◽  
Mri Contrast Agents ◽  
Sodium Acrylate ◽  
Mri Contrast ◽  
Molecular Weights ◽  
High Relaxivity ◽  
Assembly Behavior ◽  
Supramolecular Aggregates

The assembly behavior of narrowly dispersed poly(sodium acrylate) (PAAS) of different molecular weights with Gd(iii)-containing cationic metallosurfactants (MS) was investigated by DLS, TEM and relaxivity plotting.

A design strategy for small molecule-based targeted MRI contrast agents: their application for detection of atherosclerotic plaques

2014 ◽  
Vol 12 (43) ◽  
pp. 8611-8618 ◽  
Author(s):  
Shimpei Iwaki ◽  
Kazuya Hokamura ◽  
Mikako Ogawa ◽  
Yasuo Takehara ◽  
Yasuaki Muramatsu ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Small Molecule ◽  
Design Strategy ◽  
Mri Contrast Agents ◽  
Atherosclerotic Plaques ◽  
Mri Contrast ◽  
Targeted Mri

Water-Soluble Gadofullerenes:  Toward High-Relaxivity, pH-Responsive MRI Contrast Agents

2005 ◽  
Vol 127 (2) ◽  
pp. 799-805 ◽  
Author(s):  
Éva Tóth ◽  
Robert D. Bolskar ◽  
Alain Borel ◽  
Gabriel González ◽  
Lothar Helm ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Water Soluble ◽  
Ph Responsive ◽  
Mri Contrast ◽  
High Relaxivity

scholarly journals Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents

2017 ◽  
Vol 36 (3) ◽  
pp. 391-398 ◽  
Author(s):  
Hao Wang ◽  
Ting-Ting Dai ◽  
Bo-Lun Lu ◽  
Sheng-Li Li ◽  
Qing Lu ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Mri Contrast ◽  
High Relaxivity

Gadolinium complexes of macrocyclic diethylenetriamine-N-oxide pentaacetic acid-bisamide as highly stable MRI contrast agents with high relaxivity

2020 ◽  
Vol 49 (26) ◽  
pp. 8927-8932
Author(s):  
Kehan Xu ◽  
Na Xu ◽  
Beibei Zhang ◽  
Weijun Tang ◽  
Yun Ding ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gadolinium Complexes ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Mri

Macrocyclic gadolinium(iii) complexes with hyphenated-amino-N-oxide (HAO) type ligand structures are designed as efficient magnetic resonance imaging (MRI) contrast agents (CAs) with high relaxivity and stability.

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