Photophysical properties and intracellular imaging of water-soluble porphyrin dimers for two-photon excited photodynamic therapy

2009 ◽  
Vol 7 (5) ◽  
pp. 889 ◽  
Author(s):  
Marina K. Kuimova ◽  
Hazel A. Collins ◽  
Milan Balaz ◽  
Emma Dahlstedt ◽  
James A. Levitt ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Water Soluble ◽  
Intracellular Imaging ◽  
Two Photon ◽  
Water Soluble Porphyrin ◽  
Porphyrin Dimers

scholarly journals Two-Photon Photodynamic Therapy by Water-Soluble Self-Assembled Conjugated Porphyrins

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Time Resolved ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Luminescence Measurement ◽  
Water Soluble Porphyrin

Studies on two-photon absorption (2PA) photodynamic therapy (PDT) by using three water-soluble porphyrin self-assemblies consisting of ethynylene-linked conjugatedbis(imidazolylporphyrin) are reviewed. 2PA cross-section values in water were obtained by an open aperture Z-scan measurement, and values were extremely large compared with those of monomeric porphyrins such as hematoporphyrin. These compounds were found to generate singlet oxygen efficiently upon one- as well as two-photon absorption as demonstrated by the time-resolved luminescence measurement at the characteristic band of singlet oxygen at 1270 nm and by using its scavenger. Photocytotoxicities for HeLa cancer cells were examined and found to be as high as those of hematoporphyrin, demonstrating that these compounds are potential candidates for 2PA-photodynamic therapy agents.

Excited-state properties of water-soluble porphyrin dimers

1986 ◽  
Vol 130 (6) ◽  
pp. 555-559 ◽  
Author(s):  
U. Hofstra ◽  
R.B.M. Koehorst ◽  
T.J. Schaafsma
Keyword(s):  
Excited State ◽  
Water Soluble ◽  
Water Soluble Porphyrin ◽  
Porphyrin Dimers

Syntheses and properties of acetylene-linked bis- and trisporphyrins toward two-photon photodynamic therapy

2007 ◽  
Vol 11 (06) ◽  
pp. 406-417 ◽  
Author(s):  
Yusuke Inaba ◽  
Kazuya Ogawa ◽  
Yoshiaki Kobuke
Keyword(s):  
Photodynamic Therapy ◽  
Cross Section ◽  
Sodium Salt ◽  
Absorption Cross Section ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Photon Irradiation ◽  
Two Photon

Acetylene-bridged bisporphyrins and trisporphyrins having branched bulky bis(carboxylethyl)methyl meso-substituents were synthesized. These compounds showed large effective two-photon absorption cross-section values at 890 nm measured by using a nanosecond Z-scan method. Sodium salt of hydrolyzed trisporphyrins showed broad and red-shifted Q-bands over 900 nm. Two-photon absorption cross-section values of water-soluble dimers in water were similar to, or slightly larger than, those of ester forms evaluated in toluene. Furthermore, the generation of singlet oxygen upon one-photon irradiation for dimers in water was confirmed.

Water-Soluble Bis(imidazolylporphyrin) Self-Assemblies with Large Two-Photon Absorption Cross Sections as Potential Agents for Photodynamic Therapy

2006 ◽  
Vol 49 (7) ◽  
pp. 2276-2283 ◽  
Author(s):  
Kazuya Ogawa ◽  
Hideki Hasegawa ◽  
Yusuke Inaba ◽  
Yoshiaki Kobuke ◽  
Hideyuki Inouye ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cross Sections ◽  
Water Soluble ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Two Photon

Aggregation studies of benzoporphyrin derivative

2001 ◽  
Vol 79 (5-6) ◽  
pp. 1068-1074 ◽  
Author(s):  
David Delmarre ◽  
Noboru Hioka ◽  
Ron Boch ◽  
Ethan Sternberg ◽  
David Dolphin
Keyword(s):  
Dielectric Constant ◽  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Equilibrium Constants ◽  
Solvent Mixtures ◽  
Ph Values ◽  
Beer's Law ◽  
Beer’S Law ◽  
Solvent Systems ◽  
Porphyrin Dimers

The photophysical properties of a ring B benzoporphyrin derivative 1,3-diene dimethylester were investigated in solution (water–DMSO mixtures). At low proportions of water in DMSO, the diester obeys Beer's law at all pH values and ionic strengths investigated. For solvent systems containing more than 30% water, the extent of deviation from Beer's law as a function of porphyrin concentration is attributed to formation of porphyrin dimers. Dimerization equilibrium constants (Kd) have been determined in different percentage of solvent mixtures, using absorption and fluorescence spectroscopies, and were found to exhibit a linear correlation between log (Kd) and the inverse of the dielectric constant (log (Kd) = 24.6 – 1060.4 × 1/εmix). This equation permits the calculation of Kd in mixtures of water–DMSO.Key words: porphyrins, dimerization, aggregation, fluorescence, benzoporphyrin derivative, photodynamic therapy, photosensitizers.

scholarly journals One‐photon and two‐photon photophysical properties of tetrafunctionalized Temoporfin (m‐THPC) derivatives as potential agents for two‐photon induced photodynamic therapy

ChemPhotoChem ◽  
2021 ◽  
Author(s):  
Piotr Gierlich ◽  
Sebastian G. Mucha ◽  
Emma Robbins ◽  
Lígia C. Gomes-da-Silva ◽  
Katarzyna Matczyszyn ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Two Photon

scholarly journals A Luminescent, Water-Soluble Ir(III) Complex as a Potential Photosensitizer for Two-Photon Photodynamic Therapy

2021 ◽  
Vol 11 (24) ◽  
pp. 11596
Author(s):  
Elisabeta I. Szerb ◽  
Sharmistha Chatterjee ◽  
Massimo La Deda ◽  
Giovanna Palermo ◽  
Lucie Sancey ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
In Vitro Experiments ◽  
Time Resolved Fluorescence ◽  
Time Resolved ◽  
Biologically Relevant ◽  
Two Photon ◽  
Fluorescence Measurements ◽  
Detection Probe

This work reports the study of two-photon induced properties of a highly luminescent cyclometalated Ir(III) complex, [Ir(ppy)2(en)] OOCCH3 (1), ppy = 2-phenylpyridine, en = ethylenediamine. Steady-state and time-resolved fluorescence measurements were performed by exciting 1 at the biologically relevant wavelength of 800 nm, whereas, the generation of singlet oxygen (1O2) was evaluated using 9,10-Anthracenediyl-bis(methylene)dimalonic acid (ABDA) as a detection probe. Preliminary in vitro experiments with U87-MG cells were performed, showing the potential of this compound as a two-photon photodynamic therapy (2P-PDT) agent at NIR wavelengths.

Water-Soluble Conjugated Polymers for Simultaneous Two-Photon Cell Imaging and Two-Photon Photodynamic Therapy

2013 ◽  
Vol 1 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Xiaoqin Shen ◽  
Lin Li ◽  
Agnes Chow Min Chan ◽  
Nengyue Gao ◽  
Shao Q. Yao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Conjugated Polymers ◽  
Cell Imaging ◽  
Water Soluble ◽  
Two Photon

Water-soluble benzylidene cyclopentanone photosensitizers for two-photon excited photodynamic therapy

2013 ◽  
Author(s):  
Yanyan Fang ◽  
Hongyou Zhao ◽  
Qianli Zou ◽  
Yuxia Zhao ◽  
Ying Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Water Soluble ◽  
Two Photon
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