scholarly journals Development of a voltammetric technique for monitoring brain dopamine metabolism: compensation for interference caused by DOPAC electrogenerated during homovanillic acid detection

The Analyst ◽  
2009 ◽  
Vol 134 (5) ◽  
pp. 893 ◽  
Author(s):  
Ismael AL Mulla ◽  
John P. Lowry ◽  
Pier Andrea Serra ◽  
Robert D. O'Neill
Keyword(s):  
Homovanillic Acid ◽  
Dopamine Metabolism ◽  
Brain Dopamine ◽  
Voltammetric Technique

Evidence for a pathological reduction in brain dopamine metabolism in idiopathic hyperprolactinemia

1991 ◽  
Vol 125 (3) ◽  
pp. 246-252 ◽  
Author(s):  
Roberto Paradisi ◽  
Gabriele Grossi ◽  
Angela Pintore ◽  
Stefano Venturoli ◽  
Eleonora Porcu ◽  
...  
Keyword(s):  
High Performance ◽  
Homovanillic Acid ◽  
Dopamine Metabolism ◽  
Vanillylmandelic Acid ◽  
Brain Dopamine ◽  
Urinary Catecholamines ◽  
Control Subjects ◽  
Dihydroxyphenylacetic Acid ◽  
Early Follicular Phase ◽  
Urinary Dopamine

Abstract. The role of brain catecholamine activity in the neuroendocrine regulation of the dopamine-PRL system in idiopathic hyperprolactinemia was investigated by high-performance liquid chromatography with electro-chemical detector. We measured urinary dopamine, norepinephrine, epinephrine, vanillylmandelic acid, homovanillic acid, 3,4-dihydroxyphenylacetic acid and total 3-methoxy-4-hydroxyphenylglycol levels in 12 women with idiopathic hyperprolactinemia before and during either peripheral dopa-decarboxylase blockade, by carbidopa, or dopamine β-hydroxylase blockade, by disulfiram. Homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations were significantly lower (p<0.001 and p<0.005, respectively) in patients with idiopathic hyperprolactinemia compared with those in 12 control subjects in the early follicular phase, whereas they were similar to those in the control subjects in the pre-ovulatory phase. Dopamine, norepinephrine, epinephrine, vanillylmandelic acid and 3-methoxy-4-hydroxyphenylglycol concentrations were similar to those of the control subjects in both phases of the cycle. During carbidopa administration the levels of all urinary catecholamines and metabolites were unchanged, except that of dopamine which dropped remarkably (p<0.001). During disulfiram administration dopamine, homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations increased (p<0.05, p<0.001 and p<0.005, respectively) and those of norepinephrine, vanillylmandelic acid and 3-methoxy-4-hydroxyphenylglycol decreased (p<0.05, p<0.001 and p<0.005, respectively), whereas epinephrine levels remained unaltered. These data support the existence of a quantitatively reduced brain dopamine activity in idiopathic hyperprolactinemia.

Plasma homovanillic acid as an index of brain dopamine metabolism: Enhancement with debrisoquin

Life Sciences ◽  
1983 ◽  
Vol 32 (21) ◽  
pp. 2447-2452 ◽  
Author(s):  
David E. Sternberg ◽  
George R. Heninger ◽  
Robert H. Both
Keyword(s):  
Homovanillic Acid ◽  
Dopamine Metabolism ◽  
Brain Dopamine

Concomitant fall in brain dopamine and homovanillic acid in hydrocephalic rabbits

1972 ◽  
Vol 37 (3) ◽  
pp. 647-649 ◽  
Author(s):  
L. Edvinsson ◽  
K.C. Nielsen ◽  
Ch. Owman ◽  
E. Rosengren ◽  
K.A. West
Keyword(s):  
Homovanillic Acid ◽  
Brain Dopamine

Alterations in brain dopamine and serotonin metabolism during the development of tolerance to human β-endorphin in rats

1978 ◽  
Vol 56 (6) ◽  
pp. 1067-1071 ◽  
Author(s):  
Glen R. Van Loon ◽  
Errol B. De Souza ◽  
Chul Kim
Keyword(s):  
Homovanillic Acid ◽  
Single Injection ◽  
Serotonin Release ◽  
Serotonin Metabolism ◽  
Brain Dopamine ◽  
Brain Areas ◽  
Dopamine Metabolites ◽  
Initial Injection ◽  
Hydroxyindoleacetic Acid ◽  
Development Of Tolerance

Repeated intracisternal injections of human β-endorphin lead to development of tolerance with respect to the catalepsy, analgesia, and hypothermia which are seen following a single injection. The initial injection of β-endorphin results in increases in the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), in neostriatum, as well as increases in the serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), in hypothalamus and brainstem and a decrease in 5-HIAA in hippocampus. In the present study, we report changes in metabolism of dopamine and serotonin in specific brain areas during the development of tolerance to β-endorphin. Thus, the development of tolerance to β-endorphin with respect to catalepsy, analgesia, and hypothermia may be mediated by development of tolerance to the effects of β-endorphin on brain dopamine and serotonin release.

A new approach to biochemical evaluation of brain dopamine metabolism

1988 ◽  
Vol 8 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Irwin J. Kopin ◽  
J. H. White ◽  
K. Bankiewicz
Keyword(s):  
Dopamine Metabolism ◽  
Brain Dopamine ◽  
New Approach ◽  
Biochemical Evaluation
Sign in / Sign up

Export Citation Format

Share Document