Site-specific addition of D2O to the (H2O)6− “hydrated electron” cluster: isomer interconversion and substitution at the double H-bond acceptor (AA) electron-binding site

2008 ◽  
Vol 10 (21) ◽  
pp. 3118 ◽  
Author(s):  
Laura R. McCunn ◽  
Jeffrey M. Headrick ◽  
Mark A. Johnson
Keyword(s):  
Binding Site ◽  
Hydrated Electron ◽  
Site Specific ◽  
Electron Cluster ◽  
Electron Binding

Photoelectron spectroscopy of hydrated electron cluster anions, (H2O)−n=2–69

1990 ◽  
Vol 92 (6) ◽  
pp. 3980-3982 ◽  
Author(s):  
J. V. Coe ◽  
G. H. Lee ◽  
J. G. Eaton ◽  
S. T. Arnold ◽  
H. W. Sarkas ◽  
...  
Keyword(s):  
Photoelectron Spectroscopy ◽  
Hydrated Electron ◽  
Cluster Anions ◽  
Electron Cluster

Substrate binding site in bovine chymotrypsin Aγ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

Biochemistry ◽  
1971 ◽  
Vol 10 (20) ◽  
pp. 3728-3738 ◽  
Author(s):  
Philip E. Wilcox ◽  
David M. Segal ◽  
James C. Powers ◽  
Gerson H. Cohen ◽  
David R. Davies
Keyword(s):  
Binding Site ◽  
Substrate Binding ◽  
Site Specific ◽  
Substrate Binding Site ◽  
Crystallographic Study ◽  
Specific Inhibitors

scholarly journals Mapping Precursor-binding Site on TatC Subunit of Twin Arginine-specific Protein Translocase by Site-specific Photo Cross-linking

2012 ◽  
Vol 287 (16) ◽  
pp. 13430-13441 ◽  
Author(s):  
Stefan Zoufaly ◽  
Julia Fröbel ◽  
Patrick Rose ◽  
Tobias Flecken ◽  
Carlo Maurer ◽  
...  
Keyword(s):  
Binding Site ◽  
Specific Protein ◽  
Cross Linking ◽  
Site Specific

scholarly journals Disturbance of the Conformation of DNA Hairpin Containing the 5′-GT-3′ Binding Site Caused by Zn(II)bleomycin-A5 Studied through NMR Spectroscopy

2019 ◽  
Vol 5 (3) ◽  
pp. 52
Author(s):  
Covington ◽  
Lehmann
Keyword(s):  
Binding Site ◽  
Dna Cleavage ◽  
Chemical Structure ◽  
Structural Changes ◽  
Wide Spectrum ◽  
Undesirable Side Effect ◽  
Dna Hairpin ◽  
Site Specific ◽  
Dna Hairpins ◽  
Biochemical Studies

The antibiotics known as bleomycins constitute a family of natural products clinically employed for the treatment of a wide spectrum of cancers. These antibiotics have the ability to chelate a metal center, most commonly Fe(II), and cause site-specific DNA cleavage upon oxidation. Bleomycin therapy is a successful course of treatment for some types of cancers. However, the risk of pulmonary fibrosis as an undesirable side effect, limits the use of the antibiotics in cancer chemotherapy. Bleomycins are differentiated by their C-terminal, or tail, regions, which have been shown to closely interact with DNA. Pulmonary toxicity has been correlated to the chemical structure of the bleomycin C-termini through biochemical studies performed in mice. In the present study, we examined the binding of Zn(II)Bleomycin-A5 to a DNA hairpin of sequence 5′-CCAGTATTTTTACTGG-3′, containing the 5′-GT-3′ binding site. The results were compared to those from a previous study that examined the binding of Zn(II)Bleomycin-A2 and Zn(II)Peplomycin to the same DNA hairpin. We provide evidence that, as shown for DNA hairpins containing the 5′-GC-3′ binding site, Zn(II)BLM-A5 causes the most significant structural changes to the oligonucleotide.

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