Gd-complexes of DTPA-bis(amide) conjugates of tranexamic acid and its esters with high relaxivity and stability for magnetic resonance imaging

2008 ◽  
pp. 2199 ◽  
Author(s):  
Sujit Dutta ◽  
Ji-Ae Park ◽  
Jae-Chang Jung ◽  
Yongmin Chang ◽  
Tae-Jeong Kim
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tranexamic Acid ◽  
Resonance Imaging ◽  
High Relaxivity

scholarly journals A Gadolinium(III) Complex Based on the Thymine Nucleobase with Properties Suitable for Magnetic Resonance Imaging

2021 ◽  
Vol 22 (9) ◽  
pp. 4586
Author(s):  
Marta Orts-Arroyo ◽  
Amadeo Ten-Esteve ◽  
Sonia Ginés-Cárdenas ◽  
Isabel Castro ◽  
Luis Martí-Bonmatí ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Lesion Detection ◽  
Resonance Imaging ◽  
X Ray Diffraction ◽  
Functional Images ◽  
High Relaxivity ◽  
Contrast Enhanced ◽  
Phantom Studies

The paramagnetic gadolinium(III) ion is used as contrast agent in magnetic resonance (MR) imaging to improve the lesion detection and characterization. It generates a signal by changing the relaxivity of protons from associated water molecules and creates a clearer physical distinction between the molecule and the surrounding tissues. New gadolinium-based contrast agents displaying larger relaxivity values and specifically targeted might provide higher resolution and better functional images. We have synthesized the gadolinium(III) complex of formula [Gd(thy)2(H2O)6](ClO4)3·2H2O (1) [thy = 5-methyl-1H-pyrimidine-2,4-dione or thymine], which is the first reported compound based on gadolinium and thymine nucleobase. 1 has been characterized through UV-vis, IR, SEM-EDAX, and single-crystal X-ray diffraction techniques, and its magnetic and relaxometric properties have been investigated by means of SQUID magnetometer and MR imaging phantom studies, respectively. On the basis of its high relaxivity values, this gadolinium(III) complex can be considered a suitable candidate for contrast-enhanced magnetic resonance imaging.

A High Relaxivity Magnetic Resonance Imaging Contrast Agent Targeted to Serum Albumin

2008 ◽  
Vol 61 (9) ◽  
pp. 682 ◽  
Author(s):  
Stéphane Dumas ◽  
Jeffrey S. Troughton ◽  
Normand J. Cloutier ◽  
Jaclyn M. Chasse ◽  
Thomas J. McMurry ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Binding Sites ◽  
Resonance Imaging ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Contrast ◽  
Magnetic Resonance Angiographic ◽  
Imaging Contrast Agent

EP-647 is a serum albumin-targeted magnetic resonance imaging contrast agent comprising a GdDTPA (DTPA, diethylenetriaminepentaacetate) chelate for magnetic resonance signal generation linked via a phosphodiester to a substituted biphenyl for albumin targeting. Albumin binding and relaxivity are higher than the benchmark magnetic resonance angiographic agent MS-325. EP-647 binds primarily to a unique site on serum albumin that is different from the MS-325 site and the binding sites of other drugs.

A high relaxivity Gd(III)DOTA-DSPE-based liposomal contrast agent for magnetic resonance imaging

2009 ◽  
Vol 72 (2) ◽  
pp. 397-404 ◽  
Author(s):  
Sjoerd Hak ◽  
Honorius M.H.F. Sanders ◽  
Prashant Agrawal ◽  
Sander Langereis ◽  
Holger Grüll ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
High Relaxivity

Gadolinium complexes of macrocyclic diethylenetriamine-N-oxide pentaacetic acid-bisamide as highly stable MRI contrast agents with high relaxivity

2020 ◽  
Vol 49 (26) ◽  
pp. 8927-8932
Author(s):  
Kehan Xu ◽  
Na Xu ◽  
Beibei Zhang ◽  
Weijun Tang ◽  
Yun Ding ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gadolinium Complexes ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Mri

Macrocyclic gadolinium(iii) complexes with hyphenated-amino-N-oxide (HAO) type ligand structures are designed as efficient magnetic resonance imaging (MRI) contrast agents (CAs) with high relaxivity and stability.

Are All Gadolinium-based Contrast Agents Similar? The Importance of High Stability, High Relaxivity and High Concentration

2009 ◽  
Vol 4 (2) ◽  
pp. 98 ◽  
Author(s):  
Nicoletta Anzalone ◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Stability ◽  
Physicochemical Characteristics ◽  
Resonance Imaging ◽  
Contributing Factors ◽  
High Concentration ◽  
High Relaxivity ◽  
The Stability

Gadolinium-based contrast agents (GBCAs) are commonly used to enhance image acquisition via magnetic resonance imaging, but they differ in their physicochemical characteristics and therefore their function. The stability, concentration and relaxivity of a GBCA can have a major impact on clinical efficacy. Stability is related to safety. GBCAs can be categorised into three stability classes: non-ionic linear agents, ionic linear agents and macrocyclic agents, in order of increasing stability. Relaxivity and concentration are contributing factors to the level of enhancement that can be achieved with any given GBCA. Gadobutrol, gadobenate and gadoxetic acid have relatively high relaxivities. Among these compounds, only gadobutrol is commercially available at a higher concentration of 1.0M, whereas the others are used at a standard concentration of 0.5M. With high stability, relaxivity and concentration, gadobutrol has been shown in a number of clinical studies to be safe while improving image enhancement with increased conspicuity and sensitivity over other commonly used GBCAs.

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