Fast electron density methods in the life sciences—a routine application in the future?

2007 ◽  
Vol 5 (16) ◽  
pp. 2529 ◽  
Author(s):  
Peter Luger
Author(s):  
Nicholas J Severs

In his pioneering demonstration of the potential of freeze-etching in biological systems, Russell Steere assessed the future promise and limitations of the technique with remarkable foresight. Item 2 in his list of inherent difficulties as they then stood stated “The chemical nature of the objects seen in the replica cannot be determined”. This defined a major goal for practitioners of freeze-fracture which, for more than a decade, seemed unattainable. It was not until the introduction of the label-fracture-etch technique in the early 1970s that the mould was broken, and not until the following decade that the full scope of modern freeze-fracture cytochemistry took shape. The culmination of these developments in the 1990s now equips the researcher with a set of effective techniques for routine application in cell and membrane biology.Freeze-fracture cytochemical techniques are all designed to provide information on the chemical nature of structural components revealed by freeze-fracture, but differ in how this is achieved, in precisely what type of information is obtained, and in which types of specimen can be studied.


2021 ◽  
Vol 40 (2) ◽  
pp. 137-141 ◽  
Author(s):  
Jordan Mansell ◽  
Allison Harell ◽  
Elisabeth Gidengil ◽  
Patrick A. Stewart

AbstractWe introduce the Politics and the Life Sciences special issue on Psychophysiology, Cognition, and Political Differences. This issue represents the second special issue funded by the Association for Politics and the Life Sciences that adheres to the Open Science Framework for registered reports (RR). Here pre-analysis plans (PAPs) are peer-reviewed and given in-principle acceptance (IPA) prior to data being collected and/or analyzed, and are published contingent upon the preregistration of the study being followed as proposed. Bound by a common theme of the importance of incorporating psychophysiological perspectives into the study of politics, broadly defined, the articles in this special issue feature a unique set of research questions and methodologies. In the following, we summarize the findings, discuss the innovations produced by this research, and highlight the importance of open science for the future of political science research.


BioScience ◽  
1971 ◽  
Vol 21 (1) ◽  
pp. 41-42
Author(s):  
Francisco J. Ayala
Keyword(s):  

2019 ◽  
Vol 23 (08) ◽  
pp. 34-51

The following topics are under this section: The future of predicting lifestyle diseases is here in Asia Breaking Barriers for Artificial Intelligence (AI) in Healthcare: bridging vision and reality with the language of trust Overcoming Challenges of Managing Information in Life Sciences, Towards the Digital Future Under the Weather: Cybersecurity Woes in the healthcare Industry


1983 ◽  
Vol 38 (4) ◽  
pp. 465-469 ◽  
Author(s):  
David W. Allen ◽  
Lorraine A. March ◽  
Ian W. Nowell ◽  
John C. Tebby

AbstractCrystals of the title compound are monoclinic, a= 18.9 93 (11), b = 8.757(5), c= 13.267(8) Å, β = 106.60(5)°, Z = 4 in space group Cc (Cs4 , No. 9). The structure was determined by Patterson and electron-density methods and refined by least squares techniques to R= 0.081, R′ = 0.085 for 1293 independent reflections classified as observed. The molecule is found to adopt an almost regular trigonal bipyramidal geometry in which the two biphenylylene units span apical-equatorial positions and the 2-thienyl group occupies the remaining equatorial site. The 2-thienyl group, which is disordered, does not lie in the equatorial plane, and there is no indication of C2pπ → P3dπ-t interactions between the heteroaryl group and phosphorus. The steric requirements of the 2-thienyl group appear to be comparable with those of methyl and phenyl groups in bis(2,2′-biphenylylene)spiro-phosphoranes.


2017 ◽  
Vol 122 (8) ◽  
pp. 8181-8197 ◽  
Author(s):  
D. Megan Gillies ◽  
D. Knudsen ◽  
E. Donovan ◽  
B. Jackel ◽  
R. Gillies ◽  
...  

Prescriber ◽  
2018 ◽  
Vol 29 (7) ◽  
pp. 10-14
Author(s):  
Joy Ogden
Keyword(s):  

10.5912/jcb90 ◽  
2004 ◽  
Vol 10 (4) ◽  
Author(s):  
Wills Hughes-Wilson

There is around 100m annually in the Sixth Framework Programme earmarked exclusively for small and medium-sized enterprises (SMEs) in the life sciences field. That is 15 per cent of the total amount available. But most of it has yet to be allocated. Why are biopharmaceutical SMEs not applying and how can they get access to this money?The Emerging Biopharmaceutical Enterprises (EBE) group teamed up with representatives of the European Commission for the 'Life Sciences, Genomics and Biotechnology for Health' Thematic Priority to help companies understand how they can benefit from the Programme and give them an opportunity to add their ideas to it. Attendees came from 60 biopharmaceutical companies, and the programme was structured to allow companies to ask questions, but also put forward ideas to be included in upcoming Calls for the Sixth Framework Programme, as well as suggestions for improving the Seventh Framework Programme to improve industry participation. The event also gave them the chance to ask the Commission representatives specific questions on the administrative aspects of the Programme. The event was organised in conjunction with the Scientific Officers responsible for the different areas in the Programme; and the external experts who advise the Commission on the content of the future calls and the overall strategy for priority areas and activities of research were also invited. This meeting was designed to be as relaxed and open as possible and put the companies directly in contact with the people who implement the Framework Programme. The input from this session based on the feedback of the attendees has been formally forwarded to the Commission and the Thematic Priority Advisory Group.This paper discusses the aims and focus of the Sixth Framework Programme. It provides an overview of the discussion between the EBE and the representatives from the European Commission for the 'Life Sciences, Genomics and Biotechnology for Health' Thematic Priority and summarises the key problems and solutions arising therein.


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