Response to ALA-based PDT in an immortalised normal breast cell line and its counterpart transformed with the Ras oncogene

2007 ◽  
Vol 6 (12) ◽  
pp. 1306 ◽  
Author(s):  
Lorena Rodriguez ◽  
Gabriela DiVenosa ◽  
Alcira Batlle ◽  
Alexander MacRobert ◽  
Adriana Casas
Keyword(s):  
Cell Line ◽  
Normal Breast ◽  
Breast Cell Line ◽  
Ras Oncogene

scholarly journals Normal breast epithelial MCF-10A cells to evaluate the safety of carbon dots

2021 ◽  
Author(s):  
Nuno Vale ◽  
Sara Silva ◽  
Diana Duarte ◽  
Diana M. A. Crista ◽  
Luís Pinto da Silva ◽  
...  
Keyword(s):  
Cell Line ◽  
Carbon Dots ◽  
Mammary Epithelium ◽  
Structural Similarity ◽  
Normal Breast ◽  
Breast Cell Line ◽  
Toxicity Studies ◽  
Human Mammary Epithelium ◽  
Normal Human ◽  
Breast Epithelial

The human normal breast cell line MCF-10A is being widely used as a model in toxicity studies due to its structural similarity to the normal human mammary epithelium.

scholarly journals Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model

2014 ◽  
Vol 7 (1) ◽  
pp. 397 ◽  
Author(s):  
Sharon Glaysher ◽  
Louise M Bolton ◽  
Penny Johnson ◽  
Christopher Torrance ◽  
Ian A Cree
Keyword(s):  
Cell Line ◽  
Breast Cell Line ◽  
Line Model ◽  
Pi3k Inhibitors ◽  
Cell Line Model

Oncogene-induced transformation of a rat embryo fibroblast cell line is enhanced by tumor promoters

1986 ◽  
Vol 6 (6) ◽  
pp. 1943-1950
Author(s):  
W L Hsiao ◽  
T Wu ◽  
I B Weinstein
Keyword(s):  
Cell Line ◽  
Fold Increase ◽  
Fibroblast Cell ◽  
Tumor Promoters ◽  
Fibroblast Cell Line ◽  
Ras Oncogene ◽  
Rat Embryo ◽  
Synergistic Interactions ◽  
Multistage Carcinogenesis ◽  
System Tumor

Rat embryo fibroblast cell line 6 was transfected with plasmid pT24, which contains the activated human bladder c-Ha-ras oncogene, and the cells were grown continuously in the absence or presence of the tumor promoters 12-O-tetradecanoyl phorbol-13-acetate (TPA) or teleocidin. The presence of TPA or teleocidin led to a 6- to 14-fold increase in the number of morphologically transformed foci. No transformed foci were seen when rat 6 cells were transfected with the normal c-Ha-ras oncogene in the absence or presence of TPA, or in cells simply treated with TPA or teleocidin. Enhancement of pT24-induced foci was seen even when the addition of TPA was delayed until day 16. In transfection studies with the drug resistance genes gpt and neo, TPA and teleocidin did not increase the number of Gpt+ or Neo+ colonies. When rat 6 cells were cotransfected with pT24 and neo genes and grown in the absence or presence of TPA, the presence of TPA did not increase the yield of Neo+ colonies but caused a fivefold increase in the number of Neo+ colonies that displayed a transformed morphology. Southern blot analyses of DNAs obtained from these clones indicated that TPA treatment did not influence the extent of integration of either the pT24 or neo gene. DNA samples from all of the morphologically transformed cells displayed a characteristic 2-kilobase SacI fragment homologous to pT24 DNA and expressed relatively high levels of the corresponding mRNA. Our findings indicate that in this system tumor promoters do not simply enhanced the process of DNA transfection per se. Thus, this model system may be useful for analyzing synergistic interactions between tumor promoters and activated oncogenes during multistage carcinogenesis. It may also serve as a simple screening test for detecting new tumor promoters.

Demonstration of myc and ras oncogene expression by hybridization in situ in hydatidiform mole and in the BeWo choriocarcinoma cell line

1986 ◽  
Vol 154 (2) ◽  
pp. 390-393 ◽  
Author(s):  
Saumyendra Sarkar ◽  
Barry M. Kacinski ◽  
Ernest I. Kohorn ◽  
Maria J. Merino ◽  
Darryl Carter ◽  
...  
Keyword(s):  
Cell Line ◽  
Hydatidiform Mole ◽  
Ras Oncogene ◽  
Oncogene Expression ◽  
Hybridization In Situ ◽  
Choriocarcinoma Cell Line

Modulation of MDR-1 expression by a H-ras oncogene in a human colon carcinoma cell line

1993 ◽  
Vol 54 (2) ◽  
pp. 275-281 ◽  
Author(s):  
Robert Kramer ◽  
Robert Arceci ◽  
Thomas K. Weber ◽  
Barry Morse ◽  
Heather Simpson ◽  
...  
Keyword(s):  
Cell Line ◽  
Colon Carcinoma ◽  
Carcinoma Cell ◽  
Human Colon ◽  
Carcinoma Cell Line ◽  
Ras Oncogene ◽  
Human Colon Carcinoma Cell ◽  
Colon Carcinoma Cell Line ◽  
Human Colon Carcinoma ◽  
Mdr 1

Flow-cytometrically monitored chromatin in situ testing in the breast cell line H184A1N4

1994 ◽  
Vol 120 (7) ◽  
pp. 399-402
Author(s):  
H. Wei� ◽  
P. Langen ◽  
U. Nitschke ◽  
I. Thun
Keyword(s):  
Cell Line ◽  
Breast Cell Line ◽  
In Situ Testing

Tetraphenylphosphonium chloride induced mr-visible lipid accumulation in a malignant human breast cell line

1996 ◽  
Vol 67 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Edward J. Delikatny ◽  
Sandrine K. Roman ◽  
Rebecca Hancock ◽  
Thomas M. Jeitner ◽  
Catherine M. Lander ◽  
...  
Keyword(s):  
Cell Line ◽  
Lipid Accumulation ◽  
Breast Cell Line ◽  
Human Breast ◽  
Tetraphenylphosphonium Chloride ◽  
Human Breast Cell Line ◽  
Human Breast Cell ◽  
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