Surface modification of resorcinarene based self-assembled solid lipid nanoparticles for drug targeting

2007 ◽  
pp. 2605 ◽  
Author(s):  
Stefan Ehrler ◽  
Uwe Pieles ◽  
Amina Wirth-Heller ◽  
Patrick Shahgaldian
Keyword(s):  
Surface Modification ◽  
Solid Lipid Nanoparticles ◽  
Drug Targeting ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Self Assembled

scholarly journals Optimization of Redispersible Spray Dried Powder of Chitosan Coated Solid Lipid-Based Nanosystems

2018 ◽  
Vol 8 (01) ◽  
Author(s):  
Munawiroh S. Z. ◽  
Lipipun V. ◽  
Ritthidej G. C.
Keyword(s):  
Surface Modification ◽  
Spray Drying ◽  
Solid Lipid Nanoparticles ◽  
Drug Stability ◽  
Lipid Nanoparticles ◽  
Inlet Temperature ◽  
Linear Quadratic ◽  
Feed Concentration ◽  
Solid Lipid ◽  
Spray Dried

The present work describes the optimization of spray dried powder of solid lipid-based nanosystems to improve drug stability, surface modification and to obtain nanosystems after redispersion. Chitosan coated solid lipid nanoparticles containing bromocriptine mesylate (cBMSLN) were prepared by high pressure homogenization technique following by chitosan addition. For spray drying, response surface methodology with central composite rotatable design was to optimize 3 parameters: inlet temperature, pump rate and feed concentration. From regression analysis, powder yield, moisture content and size of redispersed nanoaggregates as responses were fitted well with linear, quadratic and quadratic equation models, respectively. Spherical powders with size of 4-5 µm and 70% yield were obtained at optimum parameters which were also used to prepare powder of chitosan coated nanostructured lipid carriers containing BM (cBMNLC). Amorphous characteristics were confirmed from powder XRD patterns and DSC chromatograms in all prepared powders. Redispersion of powders yielded nanosystems of some original nanosize and a greater portion of larger size. Smoother surface of NLC systems was observed, so was with chitosan coating. Drug entrapment was >85% but significantly decreased in chitosan coated formulations while drug retention after spray drying showed opposite results. After storage, spray dried powder could retain higher drug content than the original nanosystems. Obviously, NLC systems had better drug stability results than SLN systems. It could be concluded that redispersible spray dried powders of chitosan coated lipid-based nanosystems especially NLC systems were successfully obtained with surface modification, nanoaggregate size range and improved drug stability.Keywords: Solid lipid nanoparticles, nanostructure lipid carriers, chitosan, spray drying, optimization, redispersion, bromocriptine mesylate

scholarly journals Solid Lipid Nanoparticles Surface Modification Modulates Cell Internalization and Improves Chemotoxic Treatment in an Oral Carcinoma Cell Line

Nanomaterials ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 464 ◽  
Author(s):  
Lide Arana ◽  
Laura Bayón-Cordero ◽  
Laura Sarasola ◽  
Miren Berasategi ◽  
Sandra Ruiz ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Line ◽  
Solid Lipid Nanoparticles ◽  
Scale Up ◽  
Controlled Drug Release ◽  
Lipid Nanoparticles ◽  
Hydrophilic Drugs ◽  
Solid Lipid ◽  
Cell Internalization ◽  
Model Drug

Solid lipid nanoparticles (SLN) present low toxicity, versatility to incorporate both lipophilic and hydrophilic drugs, controlled drug release and they are easy to scale-up. It is well known that the endocytosis pathway by which SLN are taken up and the subsequent subcellular distribution are crucial for the biological effect of the incorporated drug. In addition, interactions between SLN and cells depend on many factors, such as, the composition of nanoparticle surface. In this work different amounts of phosphatidylethanolamine polyethylene glycol (PE–PEG) were added to SLN composed of stearic acid, Epikuron 200 and sodium taurodeoxycholate. Characterization of obtained nanoparticle suspensions were performed by the analysis of particle size, polydispersity index, ζ-potential, cell toxicity and cell internalization pathway. We have observed that the presence of PE–PEG improves active cell internalization of the nanoparticles in an oral adenocarcinoma cell line, reducing non-specific internalization mechanisms. Finally, we have tested the effect of surface coating on the efficiency of incorporated drugs using all-trans retinoic acid as a model drug. We have observed that delivery of this drug into PE–PEG coated SLN increases its chemotoxic effect compared to non-coated SLN. Therefore, it can be concluded that surface modification with PE–PEG improves the efficiency and the specificity of the SLN-loaded drug.

scholarly journals Solid lipid nanoparticles self-assembled from spray dried microparticles

2019 ◽  
Vol 572 ◽  
pp. 118784 ◽  
Author(s):  
Brenda Sanchez-Vazquez ◽  
Jong Bong Lee ◽  
Margarita Strimaite ◽  
Asma Buanz ◽  
Russell Bailey ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Self Assembled ◽  
Spray Dried

Drug Targeting by Solid Lipid Nanoparticles for Dermal Use

2002 ◽  
Vol 10 (6) ◽  
pp. 489-495 ◽  
Author(s):  
C. Santos Maia ◽  
W. Mehnert ◽  
M. Schaller ◽  
H.C. Korting ◽  
A. Gysler ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Drug Targeting ◽  
Lipid Nanoparticles ◽  
Solid Lipid

Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat

Toxicology ◽  
2020 ◽  
Vol 444 ◽  
pp. 152578
Author(s):  
Daina N. Buzyurova ◽  
Tatiana N. Pashirova ◽  
Irina V. Zueva ◽  
Evgenia A. Burilova ◽  
Zukhra M. Shaihutdinova ◽  
...  
Keyword(s):  
Surface Modification ◽  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Pralidoxime Chloride
Sign in / Sign up

Export Citation Format

Share Document