A new Cu(ii) [12]metallocrown-4 pentanuclear complex based on a Cu(ii)-malonomonohydroxamic acid unit

2007 ◽  
Vol 31 (10) ◽  
pp. 1798 ◽  
Author(s):  
Elzbieta Gumienna-Kontecka ◽  
Irina A. Golenya ◽  
Nikolay M. Dudarenko ◽  
Agnieszka Dobosz ◽  
Matti Haukka ◽  
...  
Keyword(s):  
Pentanuclear Complex ◽  
Acid Unit

Biosynthetic strategies for tetramic acid formation

2021 ◽  
Author(s):  
Xuhua Mo ◽  
Tobias A. M. Gulder
Keyword(s):  
Molecular Mechanism ◽  
Gene Clusters ◽  
Acid Formation ◽  
Biosynthetic Gene ◽  
Tetramic Acid ◽  
Biosynthetic Gene Clusters ◽  
The Individual ◽  
First Time ◽  
Acid Unit

Over 30 biosynthetic gene clusters for natural tetramate have been identified. This highlight reviews the biosynthetic strategies for formation of tetramic acid unit for the first time, discussing the individual molecular mechanism in detail.

scholarly journals Phytochemical Analysis of Anvillea garcinii Leaves: Identification of Garcinamines F–H and Their Antiproliferative Activities

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1130
Author(s):  
Hanan Y. Aati ◽  
Shagufta Perveen ◽  
Raha Orfali ◽  
Areej M. Al-Taweel ◽  
Jiangnan Peng ◽  
...  
Keyword(s):  
Cell Lines ◽  
Liver Diseases ◽  
Mcf7 Cell ◽  
Sesquiterpene Lactones ◽  
2D Nmr ◽  
Phytochemical Analysis ◽  
Antidiabetic Agent ◽  
Arab Region ◽  
New Compounds ◽  
Acid Unit

Anvillea garcinii is a medicinal plant used in the Arab region for intestinal diseases, lung and liver diseases, digestive problems, and as an antidiabetic agent. Repeated chromatographic purifications of A. garcinii leaves led to the isolation of three undescribed guaiane sesquiterpene derivatives, named garcinamines F–H, characterized by the presence of an amino acid unit, along with five known sesquiterpene lactones (garcinamines B–E and 9β-hydroxyparthenolide). The structures of the new compounds were established using spectroscopic (1D and 2D NMR) and spectrometric methods (ESIMS). Garcinamine H possesses a double bond at the Δ1,10 position, a structural feature rarely reported in guaianolide-type sesquiterpenes. The antiproliferative activity of the isolated sesquiterpenes was screened against three different cancer cell lines, and 9β-hydroxyparthenolide and garcinamines C and D displayed significant effects against lung carcinoma (A549), colon carcinoma (LoVo), and breast carcinoma (MCF7) cell lines.

Synthesis, Characterization, Investigation of Capacitance and Redox Properties of Self-assembled Phe-Phe with Ferrocene Conjugates

2021 ◽  
Author(s):  
Om Shanker Tiwari
Keyword(s):  
Nucleic Acid ◽  
Electrochemical Properties ◽  
Self Assembly ◽  
Peptide Nucleic Acid ◽  
Redox Properties ◽  
Self Assembled ◽  
Acid Unit

The synthesis, nanostructure self-assembly and electrochemical properties of a series of ferrocene conjugated peptides derived from the dipeptide Phe-Phe, nucleoside and the peptide nucleic acid unit which are covalently attached...

Synthesis of an Isotopically-labelled Antarctic Fish Antifreeze Glycoprotein Probe

2011 ◽  
Vol 64 (6) ◽  
pp. 723 ◽  
Author(s):  
Joanna M. Wojnar ◽  
Clive W. Evans ◽  
Arthur L. DeVries ◽  
Margaret A. Brimble
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Building Block ◽  
Exocrine Pancreas ◽  
Antarctic Fish ◽  
Antifreeze Glycoproteins ◽  
Threonine Residue ◽  
Antarctic Fishes ◽  
Antifreeze Glycoprotein ◽  
Acid Unit

Antifreeze glycoproteins (AFGPs) are glycosylated polypeptides produced by Antarctic and Arctic fishes, which allow them to survive in seawater at sub-zero temperatures. An investigation into the postulated enteric uptake of AFGP synthesized in the exocrine pancreas of Antarctic fishes required a custom-prepared AFGP probe that incorporated seven isotopically-labelled Ala residues for detection by mass spectrometry. The AFGPs are composed of a repetitive three amino acid unit (Ala-Ala-Thr), in which the threonine residue is glycosylated with the disaccharide β-d-Gal-(1→3)-α-d-GalNAc. The synthesis of isotopically-labelled AFGP8 (1), as well as the optimized synthesis of the protected glycosylated amino acid building block 2, is reported.

A Direct Introduction of the Mercaptoacetic Acid Unit into Amino Acid Esters

Synthesis ◽  
2003 ◽  
pp. 0019-0020 ◽  
Author(s):  
George A. Kraus ◽  
Jaehoon Bae ◽  
Prabir K. Choudhury
Keyword(s):  
Amino Acid ◽  
Mercaptoacetic Acid ◽  
Amino Acid Esters ◽  
Direct Introduction ◽  
Acid Esters ◽  
Acid Unit

scholarly journals Absolute Stereochemistry of the β-Hydroxy Acid Unit in Hantupeptins and Trungapeptins

2016 ◽  
Vol 11 (1) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Deepak Kumar Gupta ◽  
Gary Chi Ying Ding ◽  
Yong Chua Teo ◽  
Lik Tong Tan
Keyword(s):  
Amino Acid ◽  
Structural Feature ◽  
Absolute Configuration ◽  
Hydroxy Acid ◽  
Hplc Analysis ◽  
The Absolute ◽  
Absolute Stereochemistry ◽  
Common Structural Feature ◽  
Acid Unit

The β-hydroxy/amino acid unit is a common structural feature of many bioactive marine cyanobacterial depsipeptides. In this study, the absolute stereochemistry of the β-hydroxy acid moieties in hantupeptins and trungapeptins were determined through their synthesis and HPLC analysis of the Mosher ester derivatives. Synthesis of two3-hydroxy-2-methyloctanoic acid (Hmoa) stereoisomers, (2 S,3 R)-Hmoa and (2 S,3 S)-Hmoa, were achieved using diastereoselective asymmetric method and the retention times of all four Hmoa isomers were established indirectly by RPLC-MS analysis of their Mosher ester derivative standards. Based on the retention times of the standards, the absolute configuration of the Hmoa unit in hantupeptin C (3) and trungapeptin C (6) was assigned as (2 R,3 S)- and (2 S,3 R)-Hmoa, respectively. The use of the Mosher's reagents, coupled with HPLC analysis, provided a viable alternative to the absolute stereochemical determination of β-hydroxy acid units in depsipeptides.

A New Tetraprenylhydroquinone Derivative with an Acetic Acid Unit from the Marine SpongeIrciniamuscarum

1996 ◽  
Vol 59 (10) ◽  
pp. 960-961 ◽  
Author(s):  
Julia Pérez Baz ◽  
Librada M. Cañedo ◽  
Dianne Tapiolas
Keyword(s):  
Acetic Acid ◽  
Acid Unit

Enantioselective fluorescent sensor for dibenzoyl tartrate anion based on chiral binaphthyl derivatives bearing an amino acid unit

2007 ◽  
Vol 18 (15) ◽  
pp. 1769-1774 ◽  
Author(s):  
Haijuan Qin ◽  
Yongbing He ◽  
Chenguang Hu ◽  
Zhihong Chen ◽  
Ling Hu
Keyword(s):  
Amino Acid ◽  
Fluorescent Sensor ◽  
Tartrate Anion ◽  
Acid Unit
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