Synthesis and evaluation of a new polymer-supported pseudoephedrine auxiliary for asymmetric alkylations on solid phase

2007 ◽  
Vol 5 (7) ◽  
pp. 1021 ◽  
Author(s):  
Andrea M. McGhee ◽  
Jean-Claude Kizirian ◽  
David J. Procter
Keyword(s):  
Solid Phase ◽  
Polymer Supported ◽  
Asymmetric Alkylations

Recent Application of Polystyrene-supported Triphenylphosphine in Solid-Phase Organic Synthesis

2019 ◽  
Vol 23 (6) ◽  
pp. 643-678
Author(s):  
Lalthazuala Rokhum ◽  
Ghanashyam Bez
Keyword(s):  
Organic Synthesis ◽  
Combinatorial Chemistry ◽  
Solid Phase ◽  
Recent Application ◽  
Organic Transformations ◽  
Solid Phase Organic Synthesis ◽  
Wide Range ◽  
Fast Development ◽  
Polymer Supported

Recent years have witnessed a fast development of solid phase synthetic pathways, a variety of solid-supported reagent and its applications in diverse synthetic strategies and pharmaceutical applicability’s. Polymer-supported triphenylphosphine is getting a lot of applications owing to the speed and simplicity in the process. Furthermore, ease of recyclability and reuse of polymer-supported triphenylphosphine added its advantages. This review covers a wide range of useful organic transformations which are accomplished using cross-linked polystyrene-supported triphenylphosphine with the aim of giving renewed interest in the field of organic and medicinal-combinatorial chemistry.

Solid-phase synthesis of (Z)-allyl iodides from 3-acetoxy-2-methylene-alkanoates with recyclable polymer-supported selenium bromide

2007 ◽  
Vol 18 (4) ◽  
pp. 377-379 ◽  
Author(s):  
Shou Ri Sheng ◽  
Ming Gang Hu ◽  
Qin Xin ◽  
Xiao Ling Liu ◽  
Xian Huang
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Polymer Supported

scholarly journals Solid-phase organic synthesis of vinyl-substituted 1,2,4-trizoles based on polymer-supported α-selenopropionic acid

ARKIVOC ◽  
2008 ◽  
Vol 2008 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Gui-Yun Fu ◽  
Lei Guo ◽  
Xue-Chun Mao ◽  
Shou-Ri Sheng ◽  
Shi-Yang Fei ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Solid Phase Organic Synthesis ◽  
Polymer Supported

Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions

Tetrahedron ◽  
2005 ◽  
Vol 61 (15) ◽  
pp. 3819-3833 ◽  
Author(s):  
Tomoya Kotake ◽  
Yoshio Hayashi ◽  
S. Rajesh ◽  
Yoshie Mukai ◽  
Yuka Takiguchi ◽  
...  
Keyword(s):  
Solid Phase ◽  
Chiral Auxiliary ◽  
Asymmetric Alkylation ◽  
Design And Synthesis ◽  
Polymer Supported ◽  
Alkylation Reactions

Characterization of Soluble Polymer Supported Organic Molecules by Mass Spectrometry

2003 ◽  
Vol 804 ◽  
Author(s):  
C. Enjalbal ◽  
F. Lamaty ◽  
P. Ribière ◽  
S. Varray ◽  
E. Suberchicot ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Organic Molecules ◽  
Solid Phase ◽  
Combinatorial Libraries ◽  
Maldi Mass Spectrometry ◽  
Soluble Polymer ◽  
Polymer Solubility ◽  
Esi Mass Spectrometry ◽  
Polymer Supported ◽  
Phase Chemistry

ABSTRACTSyntheses carried out on soluble polymers, such as polyethylene glycol (PEG), benefit the advantages of both solution-phase and solid-phase syntheses. The choice of the reaction solvent governs the polymer solubility. Synthetic steps are conducted under homogeneous conditions whereas purifications are performed by filtration after polymer precipitation. This alternative strategy, known as liquid-phase chemistry, has been investigated to prepare combinatorial libraries.The fact that soluble polymer supported molecules are directly amenable to standard spectroscopic methods, including NMR (1H, 13C) and ESI or MALDI mass spectrometry (ElectroSpray and Matrix Assisted Laser Desorption Ionization) allows to perform to in situ reaction monitoring without the need to release the compound from the polymeric support.We report a general methodology to characterize step by step soluble polymer supported organic molecules by MALDI and ESI mass spectrometry. High throughput analyses were targeted to fullfil combinatorial chemistry requirements. Data acquisition and interpretation were automated through the design of specific experimental protocols and a data managment software. MALDI mass spectrometry was appropriate to analyze pure supported molecules whereas ESI mass spectrometry coupled to liquid chromatography was required to unravel PEG mixtures.

Solid-phase intramolecular oxyselenenylation and deselenenylation reactions using polymer-supported selenoreagents and their application to aqueous media organic synthesis

2003 ◽  
Vol 5 (5) ◽  
pp. 549-553 ◽  
Author(s):  
Ken-ichi Fujita ◽  
Shigeru Hashimoto ◽  
Mitsuhiro Kanakubo ◽  
Akihiro Oishi ◽  
Yoichi Taguchi
Keyword(s):  
Organic Synthesis ◽  
Solid Phase ◽  
Aqueous Media ◽  
Polymer Supported
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