Pressure-driven spatiotemporal control of the laminar flow interface in a microfluidic network

Lab on a Chip ◽  
2007 ◽  
Vol 7 (5) ◽  
pp. 647 ◽  
Author(s):  
Brandon Kuczenski ◽  
Philip R. LeDuc ◽  
William C. Messner
Keyword(s):  
Laminar Flow ◽  
Microfluidic Network ◽  
Spatiotemporal Control ◽  
Pressure Driven

scholarly journals Pressure-driven laminar flow switching for rapid exchange of solution environment around surface adhered biological particles

Lab on a Chip ◽  
2010 ◽  
Vol 10 (6) ◽  
pp. 727 ◽  
Author(s):  
Peter B. Allen ◽  
Graham Milne ◽  
Byron R. Doepker ◽  
Daniel T. Chiu
Keyword(s):  
Laminar Flow ◽  
Biological Particles ◽  
Rapid Exchange ◽  
Pressure Driven

An Automated System for Controlling the Laminar Flow Interface in a Microfluidic System

2004 ◽  
Author(s):  
Brandon Kuczenski ◽  
Philip R. LeDuc ◽  
William C. Messner
Keyword(s):  
Laminar Flow ◽  
Feedback System ◽  
Microfluidic System ◽  
Automated System ◽  
Time Varying ◽  
Relative Flow Rate ◽  
Microfluidic Network ◽  
Piezoresistive Pressure Sensor ◽  
Pressure Feedback ◽  
And Performance

The interface between adjacent laminar flow streams in the output channel of a Y-shaped confluent microfluidic network is useful for investigating the response of individual living cells to steep chemical gradients. This paper reports the design and performance of an automated pressure-feedback system for accurately and rapidly changing the position of that interface. The device will be employed to investigate the dynamic response of cells to time-varying chemical stimulation. The system works by controlling the pressure difference between the two adjoining inputs of the microfluidic network, altering the relative flow rate of the laminar streams in the output microchannel. Continuity of incompressible fluids dictates that the plane of the interface between the two streams will move from side to side as the flow rates change. The sample-data control system samples a temperature-compensated monolithic piezoresistive pressure sensor at 1 kilohertz, allowing the control of high-bandwidth microfluidic systems. This automated system enables long-duration, high-precision experiments that involve time-varying parameters to be performed simply, rapidly, and inexpensively.

Pressure-Driven Laminar Flow in Tangential Microchannels:  an Elastomeric Microfluidic Switch

2001 ◽  
Vol 73 (19) ◽  
pp. 4682-4687 ◽  
Author(s):  
Rustem F. Ismagilov ◽  
David Rosmarin ◽  
Paul J. A. Kenis ◽  
Daniel T. Chiu ◽  
Wendy Zhang ◽  
...  
Keyword(s):  
Laminar Flow ◽  
Microfluidic Switch ◽  
Pressure Driven

Numerical design and optimization of hydraulic resistance and wall shear stress inside pressure-driven microfluidic networks

Lab on a Chip ◽  
2015 ◽  
Vol 15 (21) ◽  
pp. 4187-4196 ◽  
Author(s):  
Hazem Salim Damiri ◽  
Hamzeh Khalid Bardaweel
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Hydraulic Resistance ◽  
Design And Optimization ◽  
Microfluidic Network ◽  
Numerical Design ◽  
Microfluidic Networks ◽  
Wall Shear ◽  
Pressure Driven

Control of total wall shear stress in ann-generation microfluidic network.

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