Heterostructured magnetic nanoparticles: their versatility and high performance capabilities

2007 ◽  
pp. 1203-1214 ◽  
Author(s):  
Young-wook Jun ◽  
Jin-sil Choi ◽  
Jinwoo Cheon
Keyword(s):  
Magnetic Nanoparticles ◽  
High Performance

High-Performance Functionalized Magnetic Nanoparticles with Tailored Sizes and Shapes for Localized Hyperthermia Applications

2021 ◽  
Author(s):  
Izabell Crăciunescu ◽  
Petru Palade ◽  
Nicuşor Iacob ◽  
George Marian Ispas ◽  
Anda Elena Stanciu ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
High Performance ◽  
Functionalized Magnetic Nanoparticles

Characterization of Fe3O4@CS@NMDP magnetic nanoparticles with core–shell structure prepared by chemical cross-linking method

2017 ◽  
Vol 10 (05) ◽  
pp. 1750056 ◽  
Author(s):  
Huiping Shao ◽  
Jiangcong Qi ◽  
Tao Lin ◽  
Yuling Zhou ◽  
Fucheng Yu
Keyword(s):  
Magnetic Nanoparticles ◽  
Shell Structure ◽  
High Performance ◽  
Cross Linking ◽  
Composite Particles ◽  
Core Shell ◽  
The Core ◽  
Targeting Delivery ◽  
Core Shell Structure ◽  
Chemical Cross Linking

The core–shell structure composite magnetic nanoparticles (NPs), Fe3O4@chitosan@nimodipine (Fe3O4@CS@NMDP), were successfully synthesized by a chemical cross-linking method in this paper. NMDP is widely used for cardiovascular and cerebrovascular disease prevention and treatment, while CS is of biocompatibility. The composite particles were characterized by an X-ray diffractometer (XRD), a Fourier transform infrared spectroscopy (FT-IR), a transmission electron microscopy (TEM), a vibrating sample magnetometers (VSM) and a high performance liquid chromatography (HPLC). The results show that the size of the core–shell structure composite particles is ranging from 12[Formula: see text]nm to 20[Formula: see text]nm and the coating thickness of NMDP is about 2[Formula: see text]nm. The saturation magnetization of core–shell composite NPs is 46.7[Formula: see text]emu/g, which indicates a good potential application for treating cancer by magnetic target delivery. The release percentage of the NMDP can reach 57.6% in a short time of 20[Formula: see text]min in the PBS, and to 100% in a time of 60[Formula: see text]min, which indicates the availability of Fe3O4@CS@NMDP composite NPs for targeting delivery treatment.

scholarly journals ZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from < 1 µL Serum

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2159
Author(s):  
Tiara Pradita ◽  
Yi-Ju Chen ◽  
Elias Gizaw Mernie ◽  
Sharine Noelle Bendulo ◽  
Yu-Ju Chen
Keyword(s):  
Magnetic Nanoparticles ◽  
High Performance ◽  
Large Scale ◽  
Structural Complexity ◽  
High Sensitivity ◽  
Protein Glycosylation ◽  
Rapid Separation ◽  
Glycopeptide Enrichment ◽  
Human Proteins ◽  
Differential Pattern

Due to their unique glycan composition and linkage, protein glycosylation plays significant roles in cellular function and is associated with various diseases. For comprehensive characterization of their extreme structural complexity occurring in >50% of human proteins, time-consuming multi-step enrichment of glycopeptides is required. Here we report zwitterionic n-dodecylphosphocholine-functionalized magnetic nanoparticles (ZIC-cHILIC@MNPs) as a highly efficient affinity nanoprobe for large-scale enrichment of glycopeptides. We demonstrate that ZIC-cHILIC@MNPs possess excellent affinity, with 80–91% specificity for glycopeptide enrichment, especially for sialylated glycopeptide (90%) from biofluid specimens. This strategy provides rapidity (~10 min) and high sensitivity (<1 μL serum) for the whole enrichment process in patient serum, likely due to the rapid separation using magnetic nanoparticles, fast reaction, and high performance of the affinity nanoprobe at nanoscale. Using this strategy, we achieved personalized profiles of patients with hepatitis B virus (HBV, n = 3) and hepatocellular carcinoma (HCC, n = 3) at the depth of >3000 glycopeptides, especially for the large-scale identification of under-explored sialylated glycopeptides. The glycoproteomics atlas also revealed the differential pattern of sialylated glycopeptides between HBV and HCC groups. The ZIC-cHILIC@MNPs could be a generic tool for advancing the glycoproteome analysis, and contribute to the screening of glycoprotein biomarkers.

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