Allylic hydrogen abstraction II. H-abstraction from 1,4 type polyalkenes as a model for free radical trapping by polyunsaturated fatty acids (PUFAs)

2007 ◽  
Vol 9 (16) ◽  
pp. 1931 ◽  
Author(s):  
Milan Szori ◽  
Tamas Abou-Abdo ◽  
Christa Fittschen ◽  
Imre G. Csizmadia ◽  
Bela Viskolcz
Keyword(s):  
Fatty Acids ◽  
Free Radical ◽  
Polyunsaturated Fatty Acids ◽  
Hydrogen Abstraction ◽  
Radical Trapping

scholarly journals Isotope-reinforced polyunsaturated fatty acids improve Parkinson’s disease-like phenotype in rats overexpressing α-synuclein

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
M. Flint Beal ◽  
Jayandra Chiluwal ◽  
Noel Y. Calingasan ◽  
Ginger L. Milne ◽  
Mikhail S. Shchepinov ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Fatty Acids ◽  
Parkinson's Disease ◽  
Polyunsaturated Fatty Acids ◽  
Mitochondrial Dysfunction ◽  
Hydrogen Abstraction ◽  
Neuronal Loss ◽  
Motor Deficits ◽  
Beneficial Effects ◽  
Neuroprotective Therapy

AbstractLipid peroxidation is a key to a portfolio of neurodegenerative diseases and plays a central role in α-synuclein (α-syn) toxicity, mitochondrial dysfunction and neuronal death, all key processes in the pathogenesis of Parkinson’s disease (PD). Polyunsaturated fatty acids (PUFAs) are important constituents of the synaptic and mitochondrial membranes and are often the first molecular targets attacked by reactive oxygen species (ROS). The rate-limiting step of the chain reaction of ROS-initiated PUFAs autoxidation involves hydrogen abstraction at bis-allylic sites, which can be slowed down if hydrogens are replaced with deuteriums. In this study, we show that targeted overexpression of human A53T α-syn using an AAV vector unilaterally in the rat substantia nigra reproduces some of pathological features seen in PD patients. Chronic dietary supplementation with deuterated PUFAs (D-PUFAs), specifically 0.8% D-linoleic and 0.3% H-linolenic, produced significant disease-modifying beneficial effects against α-syn-induced motor deficits, synaptic pathology, oxidative damage, mitochondrial dysfunction, disrupted trafficking along axons, inflammation and DA neuronal loss. These findings support the clinical evaluation of D-PUFAs as a neuroprotective therapy for PD.

scholarly journals Vliyanie ω-3-polinenasyshchennykh zhirnykh kislot na svobodnoradikal'nye protsessy i strukturnoe sostoyanie membran eritrotsitov u patsientov s metabolicheskim sindromom

2010 ◽  
Vol 7 (3) ◽  
pp. 34-37
Author(s):  
N N Kraynova ◽  
N I Volkova ◽  
T P Popova ◽  
M S Komurdzhants ◽  
V V Vnukov
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Enzyme Activity ◽  
Free Radical ◽  
Insulin Sensitivity ◽  
Polyunsaturated Fatty Acids ◽  
Membrane Structure ◽  
Antioxidant Enzyme Activity ◽  
Tissue Sensitivity ◽  
Free Radical Activity

This article presents data on tissue sensitivity to insulin, type of change in antioxidant-prooxidant system and membrane structure of erythrocytes in 30 patients from 20 to 58 years of age with metabolic syndrome who received a preparation of ω-3 polyunsaturated fatty acids. After 3 months of treatment with omacor we revealed the increase in the tissue insulin sensitivity, lowering of the free radical activity, normalization of antioxidant enzyme activity and erythrocytes membranes stabilization.

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