Soft biological materials and their impact on cell function

Soft Matter ◽  
2007 ◽  
Vol 3 (3) ◽  
pp. 299-306 ◽  
Author(s):  
Ilya Levental ◽  
Penelope C. Georges ◽  
Paul A. Janmey
Keyword(s):  
Cell Function ◽  
Biological Materials ◽  
Soft Biological Materials

3D Printed lattice microstructures to mimic soft biological materials

2018 ◽  
Vol 14 (1) ◽  
pp. 016001
Author(s):  
Luke K Johnson ◽  
Chris Richburg ◽  
Madelyn Lew ◽  
William R Ledoux ◽  
Patrick M Aubin ◽  
...  
Keyword(s):  
Biological Materials ◽  
3D Printed ◽  
Soft Biological Materials

scholarly journals Nanoindentation of Soft Biological Materials

Micromachines ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 654 ◽  
Author(s):  
Long Qian ◽  
Hongwei Zhao
Keyword(s):  
Mechanical Properties ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Biological Materials ◽  
Constitutive Behavior ◽  
Force Sensitivity ◽  
Organ Level ◽  
Soft Biological Materials ◽  
Soft Biomaterials ◽  
Indentation Response

Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently been moved into the center of the spotlight for measuring the mechanical properties of biomaterials, especially bridging the scales from the molecular via the cellular and tissue all the way to the organ level, whereas characterizing soft biomaterials, especially down to biomolecules, is fraught with more pitfalls compared with the hard biomaterials. In this review we detail the constitutive behavior of soft biomaterials under nanoindentation (including AFM) and present the characteristics of experimental aspects in detail, such as the adaption of instrumentation and indentation response of soft biomaterials. We further show some applications, and discuss the challenges and perspectives related to nanoindentation of soft biomaterials, a technique that can pinpoint the mechanical properties of soft biomaterials for the scale-span is far-reaching for understanding biomechanics and mechanobiology.

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