scholarly journals The type I fatty acid and polyketide synthases: a tale of two megasynthases

2007 ◽  
Vol 24 (5) ◽  
pp. 1041 ◽  
Author(s):  
Stuart Smith ◽  
Shiou-Chuan Tsai
Keyword(s):  
Fatty Acid ◽  
Polyketide Synthases ◽  
Type I

scholarly journals The architectures of iterative type I PKS and FAS

2018 ◽  
Vol 35 (10) ◽  
pp. 1046-1069 ◽  
Author(s):  
Dominik A. Herbst ◽  
Craig A. Townsend ◽  
Timm Maier
Keyword(s):  
Fatty Acid ◽  
Polyketide Synthases ◽  
Type I ◽  
Fatty Acid Synthases

The architectures of fatty acid synthases and iterative polyketide synthases are remarkably divergent despite their related biosynthetic logics.

The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases

2018 ◽  
Vol 87 (1) ◽  
pp. 503-531 ◽  
Author(s):  
Shiou-Chuan (Sheryl) Tsai
Keyword(s):  
Fatty Acid ◽  
Potential Application ◽  
Large Family ◽  
Polyketide Synthases ◽  
Type I ◽  
Type Ii ◽  
Critical Comparison ◽  
Multienzyme Complexes ◽  
Structural Enzymology ◽  
Fatty Acid Synthases

Polyketides are a large family of structurally complex natural products including compounds with important bioactivities. Polyketides are biosynthesized by polyketide synthases (PKSs), multienzyme complexes derived evolutionarily from fatty acid synthases (FASs). The focus of this review is to critically compare the properties of FASs with iterative aromatic PKSs, including type II PKSs and fungal type I nonreducing PKSs whose chemical logic is distinct from that of modular PKSs. This review focuses on structural and enzymological studies that reveal both similarities and striking differences between FASs and aromatic PKSs. The potential application of FAS and aromatic PKS structures for bioengineering future drugs and biofuels is highlighted.

scholarly journals Production of long chain alcohols and alkanes upon coexpression of an acyl-ACP reductase and aldehyde-deformylating oxygenase with a bacterial type-I fatty acid synthase in E. coli

2015 ◽  
Vol 11 (9) ◽  
pp. 2464-2472 ◽  
Author(s):  
Dan Coursolle ◽  
Jiazhang Lian ◽  
John Shanklin ◽  
Huimin Zhao
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Type I ◽  
E Coli ◽  
Bacterial Type ◽  
Long Chain

An orthogonal type I FAS was introduced into E. coli to increase the production of long chain alcohols and alkanes.

scholarly journals Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid–type III polyketide synthase

2006 ◽  
Vol 2 (9) ◽  
pp. 494-502 ◽  
Author(s):  
Michael B Austin ◽  
Tamao Saito ◽  
Marianne E Bowman ◽  
Stephen Haydock ◽  
Atsushi Kato ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Dictyostelium Discoideum ◽  
Polyketide Synthase ◽  
Type I ◽  
Type Iii Polyketide Synthase ◽  
Type Iii ◽  
Hybrid Type ◽  
Acid Type ◽  
Fatty Acid Type

A novel group of type I polyketide synthases (PKS) in animals and the complex phylogenomics of PKSs

Gene ◽  
2007 ◽  
Vol 392 (1-2) ◽  
pp. 47-58 ◽  
Author(s):  
Todd A. Castoe ◽  
Tricia Stephens ◽  
Brice P. Noonan ◽  
Cristina Calestani
Keyword(s):  
Polyketide Synthases ◽  
Type I
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