A high accuracy primary ratio method for the determination of iodine in complex matrices by double isotope dilution using MC-ICPMS and 129I spike

2006 ◽  
Vol 21 (4) ◽  
pp. 413 ◽  
Author(s):  
Rebeca Santamaria-Fernandez ◽  
Peter Evans ◽  
Céline S. J. Wolff-Briche ◽  
Ruth Hearn
Keyword(s):  
Isotope Dilution ◽  
High Accuracy ◽  
Ratio Method ◽  
Complex Matrices ◽  
Double Isotope

A DOUBLE ISOTOPE DERIVATIVE METHOD FOR THE DETERMINATION OF ALDOSTERONE IN PERIPHERAL PLASMA

1961 ◽  
Vol 37 (4) ◽  
pp. 541-558 ◽  
Author(s):  
Ejgil Bojesen ◽  
Hans Degn
Keyword(s):  
Isotope Dilution ◽  
Half Life ◽  
Acid Anhydride ◽  
Hydroxyl Group ◽  
Aldosterone Level ◽  
Peripheral Plasma ◽  
Derivative Method ◽  
Double Isotope

ABSTRACT The details of a method for the determination of aldosterone at the level of 1 ng or more are described. A combination of the isotope derivative principle and the isotope dilution principle, using 35S and 131I labelled piodobenzenesulfonic acid anhydride (pipsan) as the labelled reagents, has been employed. A quantitative or almost quantitative and reproducible esterification of the 21-hydroxyl group of aldosterone and an 80% recovery of the steroid added to plasma can be achieved by the procedure described. The blank value has been determined by the analysis of epripheral plasma of adrenalectomized dogs and was found to be indistinguishable from zero and therefore less than 3 ng per 100 ml of plasma. In salt depleted anaesthetized dogs the aldosterone level was 20–30 ng per 100 ml. The concentration increased considerably during adrenalectomy and decreased with a »half life« of 20–30 minutes from the time this was completed.

High accuracy isotope dilution analysis for the determination of ethanol using gas chromatography-combustion-isotope ratio mass spectrometry

The Analyst ◽  
2000 ◽  
Vol 125 (12) ◽  
pp. 2189-2195 ◽  
Author(s):  
Céline S. J. Wolff Briche ◽  
Gavin O’Connor ◽  
Ken S. Webb ◽  
Tim Catterick ◽  
Helena Hernández
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Isotope Dilution ◽  
Isotope Ratio ◽  
Isotope Ratio Mass Spectrometry ◽  
High Accuracy ◽  
Isotope Dilution Analysis
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