Application of electronic circular dichroism in configurational and conformational analysis of organic compounds

2007 ◽  
Vol 36 (6) ◽  
pp. 914 ◽  
Author(s):  
Nina Berova ◽  
Lorenzo Di Bari ◽  
Gennaro Pescitelli
Keyword(s):  
Circular Dichroism ◽  
Conformational Analysis ◽  
Organic Compounds ◽  
Electronic Circular Dichroism ◽  
Circular Dichroïsm

Enantiopure methoxetamine stereoisomers: chiral resolution, conformational analysis, UV-circular dichroism spectroscopy and electronic circular dichroism

2021 ◽  
Author(s):  
Kun Won Lee ◽  
Ahmed H. E. Hassan ◽  
Youngdo Jeong ◽  
Seolmin Yoon ◽  
Seung-Hwan Kim ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Conformational Analysis ◽  
Absolute Configuration ◽  
Circular Dichroism Spectroscopy ◽  
Chiral Resolution ◽  
Treatment Resistant Depression ◽  
Treatment Resistant ◽  
Electronic Circular Dichroism ◽  
Resistant Depression ◽  
Circular Dichroïsm

Enantioseparation and assignment of absolute configuration of methoxetamine (MXE) enantiopure stereoisomers; a promising novel antidepressant for management of treatment-resistant depression.

Conformational Analysis of XA and AX Dipeptides in Water by Electronic Circular Dichroism and1H NMR Spectroscopy

2006 ◽  
Vol 110 (13) ◽  
pp. 6979-6986 ◽  
Author(s):  
Andrew Hagarman ◽  
Thomas Measey ◽  
Ravi S. Doddasomayajula ◽  
Isabelle Dragomir ◽  
Fatma Eker ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Nmr Spectroscopy ◽  
Conformational Analysis ◽  
Electronic Circular Dichroism ◽  
Circular Dichroïsm

Vibrational and electronic circular dichroism as powerful tools for the conformational analysis of cationic antimicrobial peptides

2016 ◽  
Vol 147 (8) ◽  
pp. 1439-1445 ◽  
Author(s):  
Lucie Kocourková ◽  
Pavlína Novotná ◽  
Lucie Šťovíčková-Habartová ◽  
Sabína Čujová ◽  
Václav Čeřovský ◽  
...  
Keyword(s):  
Circular Dichroism ◽  
Antimicrobial Peptides ◽  
Conformational Analysis ◽  
Electronic Circular Dichroism ◽  
Cationic Antimicrobial Peptides ◽  
Circular Dichroïsm

scholarly journals Mass-resolved electronic circular dichroism ion spectroscopy

Science ◽  
2020 ◽  
Vol 368 (6498) ◽  
pp. 1465-1468 ◽  
Author(s):  
Steven Daly ◽  
Frédéric Rosu ◽  
Valérie Gabelica
Keyword(s):  
Circular Dichroism ◽  
Three Dimensional ◽  
Polarized Light ◽  
Negative Ions ◽  
Data Interpretation ◽  
Electronic Circular Dichroism ◽  
Circularly Polarized Light ◽  
Chiral Compounds ◽  
Electron Photodetachment ◽  
Circular Dichroïsm

DNA and proteins are chiral: Their three-dimensional structures cannot be superimposed with their mirror images. Circular dichroism spectroscopy is widely used to characterize chiral compounds, but data interpretation is difficult in the case of mixtures. We recorded the electronic circular dichroism spectra of DNA helices separated in a mass spectrometer. We studied guanine-rich strands having various secondary structures, electrosprayed them as negative ions, irradiated them with an ultraviolet nanosecond optical parametric oscillator laser, and measured the difference in electron photodetachment efficiency between left and right circularly polarized light. The reconstructed circular dichroism ion spectra resembled those of their solution-phase counterparts, thereby allowing us to assign the DNA helical topology. The ability to measure circular dichroism directly on biomolecular ions expands the capabilities of mass spectrometry for structural analysis.

Chemical Constituents from Chloranthus elatior and Their Inhibitory Effect on Human Dihydroorotate Dehydrogenase

Planta Medica ◽  
2021 ◽  
Author(s):  
Qian Yang ◽  
An Jia ◽  
Xizi Liu ◽  
Shiyi Han ◽  
Siyang Fan
Keyword(s):  
Circular Dichroism ◽  
Chemical Constituents ◽  
Inhibitory Effect ◽  
Mass Spectrometric ◽  
Dihydroorotate Dehydrogenase ◽  
Active Compounds ◽  
Electronic Circular Dichroism ◽  
Aerial Parts ◽  
Ic50 Values ◽  
Circular Dichroïsm

AbstractA new sesquiterpene, chlorantholide G (1), a new sesquiterpene dimer, elatiolactone (2), and 2 new diterpenes, elatiorlabdane B (3) and elatiorlabdane C (4), together with 51 known compounds, were isolated from the aerial parts of Chloranthus elatior. The new structures including their absolute configurations were mainly established by mass spectrometric, NMR, and electronic circular dichroism experiments. All isolated compounds were tested for their anti-hDHODH activity. (4S,6R)-4-hydroxy-6-isopropyl-3-methylcyclohex-2-enone (5) and (4S,5R,9S,10R)-8(17),12,14-labdatrien-18-oic acid (29) were the most active compounds with IC50 values of 18.7 and 30.7 µM, respectively.

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