Continuous flow separation of particles within an asymmetric microfluidic device

Lab on a Chip ◽  
2006 ◽  
Vol 6 (4) ◽  
pp. 561 ◽  
Author(s):  
Xunli Zhang ◽  
Jon M. Cooper ◽  
Paul B. Monaghan ◽  
Stephen J. Haswell
Keyword(s):  
Microfluidic Device ◽  
Flow Separation ◽  
Continuous Flow

scholarly journals Non-Aqueous Continuous-Flow Electrophoresis (NACFE): Separation Complement for Continuous-Flow Organic Synthesis

2019 ◽  
Author(s):  
Nikita A. Ivanov ◽  
Yimo Liu ◽  
Sven Kochmann ◽  
Sergey N. Krylov
Keyword(s):  
Steady State ◽  
Organic Synthesis ◽  
Flow Separation ◽  
Continuous Flow ◽  
Organic Molecules ◽  
Water Electrolysis ◽  
Organic Salt ◽  
Aqueous Electrolytes ◽  
Differential Distribution ◽  
Steady State Operation

<div>Continuous-flow organic synthesis naturally requires continuous-flow separation of reaction components. The most common continuous-flow separation approach is liquid-liquid extraction based on differential distribution of molecules between organic and aqueous phases. This approach has limited selectivity; it can hardly separate different hydrophobic organic molecules from each other. Continuous-flow electrophoresis can facilitate much more selective separation in a single phase, but it is currently limited to aqueous electrolytes which are incompatible with many hydrophobic organic molecules. Further, water electrolysis in aqueous electrolytes results in generation of large volumes of gas making steady-state operation a major technical challenge. Here, we introduce non-aqueous continuous-flow electrophoresis (NACFE) in which the electrolyte is a solution of an organic salt in an aprotic organic solvent. We demonstrate that NACFE can maintain stable separation of multiple species during 10 hours. The non-aqueous nature of NACFE and its ability to support steady-state operation make it suitable for its incorporation into continuous-flow organic synthesis.</div>

Continuous-flow, well-mixed, microfluidic crystallization device for screening of polymorphs, morphology, and crystallization kinetics at controlled supersaturation

Lab on a Chip ◽  
2019 ◽  
Vol 19 (14) ◽  
pp. 2373-2382 ◽  
Author(s):  
Paria Coliaie ◽  
Manish S. Kelkar ◽  
Nandkishor K. Nere ◽  
Meenesh R. Singh
Keyword(s):  
Crystallization Kinetics ◽  
Microfluidic Device ◽  
Continuous Flow ◽  
Crystalline Materials ◽  
Screening Techniques

While the conventional screening techniques suffer from depletion of supersaturation, the continuous-flow microfluidic device screens crystalline materials at controlled supersaturation.

Continuous Dielectrophoretic Separation of Multiple Particles in a Microfluidic Chip

2008 ◽  
Author(s):  
Christian Davidson ◽  
Junjie Zhu ◽  
Xiangchun Xuan
Keyword(s):  
Particle Size ◽  
Electric Field ◽  
Flow Separation ◽  
Microfluidic Chip ◽  
Continuous Flow ◽  
Uniform Electric Field ◽  
Dielectrophoretic Force ◽  
Size Dependent ◽  
Multiple Particles ◽  
Dc Dielectrophoresis

We successfully demonstrate that DC dielectrophoresis can be utilized to separate particles of three dissimilar sizes simultaneously in a microfluidic chip. This continuous-flow separation is attributed to the particle size dependent dielectrophoretic force that is generated by the non-uniform electric field around a single insulating hurdle on the channel sidewall.

Continuous-flow separation of nanoparticles by electrostatic sieving at a micro-nanofluidic interface

2011 ◽  
Vol 34 (10) ◽  
pp. 1180-1183 ◽  
Author(s):  
Jan Regtmeier ◽  
Jörg Käsewieter ◽  
Martina Everwand ◽  
Dario Anselmetti
Keyword(s):  
Flow Separation ◽  
Continuous Flow

The effect of fluidic conditions on the continuous-flow bioluminescent detection of ATP in a microfluidic device

2007 ◽  
Vol 12 (5) ◽  
pp. 470-474 ◽  
Author(s):  
Thuan-Hieu Tran ◽  
Woo-Jin Chang ◽  
Young-Bum Kim ◽  
Yoon-Mo Koo ◽  
Eun-Ki Kim ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Continuous Flow
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