Rapid methylation on carbon frameworks useful for the synthesis of 11CH3-incorporated PET tracers: Pd(0)-mediated rapid coupling of methyl iodide with an alkenyltributylstannane leading to a 1-methylalkene

2006 ◽  
Vol 4 (3) ◽  
pp. 410 ◽  
Author(s):  
Takamitsu Hosoya ◽  
Kengo Sumi ◽  
Hisashi Doi ◽  
Masahiro Wakao ◽  
Masaaki Suzuki
Keyword(s):  
Methyl Iodide ◽  
Pet Tracers

Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Synthesis of11CH3-Labeled PET Tracers

1997 ◽  
Vol 3 (12) ◽  
pp. 2039-2042 ◽  
Author(s):  
Masaaki Suzuki ◽  
Hisashi Doi ◽  
Margareta Björkman ◽  
Yvonne Andersson ◽  
Bengt Långström ◽  
...  
Keyword(s):  
Methyl Iodide ◽  
Pet Tracers

As a (white) matter of fact – Different white matter properties of beta-amyloid PET tracers

2020 ◽  
Author(s):  
M Rullmann ◽  
PL Flender ◽  
V Villemagne ◽  
O Sabri ◽  
H Barthel
Keyword(s):  
White Matter ◽  
Beta Amyloid ◽  
Amyloid Pet ◽  
Pet Tracers

Dosimetrie und Biodistribution des Alzheimer-Plaque bindenden PET-Tracers [11C]BTA-1

2007 ◽  
Vol 179 (S 1) ◽  
Author(s):  
S Thees ◽  
B Neumaier ◽  
G Glatting ◽  
S Deisenhofer ◽  
T Kahn ◽  
...  
Keyword(s):  
Pet Tracers

Usefulness of positron emission tomography for differentiating gliomas according to the 2016 World Health Organization classification of tumors of the central nervous system

2020 ◽  
Vol 133 (4) ◽  
pp. 1010-1019 ◽  
Author(s):  
Hiroaki Takei ◽  
Jun Shinoda ◽  
Soko Ikuta ◽  
Takashi Maruyama ◽  
Yoshihiro Muragaki ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Pet Imaging ◽  
Who Classification ◽  
Standardized Uptake Value ◽  
Emission Tomography ◽  
World Health ◽  
Pet Tracers ◽  
Positron Emission ◽  
Significant Difference ◽  
The Mean

OBJECTIVEPositron emission tomography (PET) is important in the noninvasive diagnostic imaging of gliomas. There are many PET studies on glioma diagnosis based on the 2007 WHO classification; however, there are no studies on glioma diagnosis using the new classification (the 2016 WHO classification). Here, the authors investigated the relationship between uptake of 11C-methionine (MET), 11C-choline (CHO), and 18F-fluorodeoxyglucose (FDG) on PET imaging and isocitrate dehydrogenase (IDH) status (wild-type [IDH-wt] or mutant [IDH-mut]) in astrocytic and oligodendroglial tumors according to the 2016 WHO classification.METHODSIn total, 105 patients with newly diagnosed cerebral gliomas (6 diffuse astrocytomas [DAs] with IDH-wt, 6 DAs with IDH-mut, 7 anaplastic astrocytomas [AAs] with IDH-wt, 24 AAs with IDH-mut, 26 glioblastomas [GBMs] with IDH-wt, 5 GBMs with IDH-mut, 19 oligodendrogliomas [ODs], and 12 anaplastic oligodendrogliomas [AOs]) were included. All OD and AO patients had both IDH-mut and 1p/19q codeletion. The maximum standardized uptake value (SUV) of the tumor/mean SUV of normal cortex (T/N) ratios for MET, CHO, and FDG were calculated, and the mean T/N ratios of DA, AA, and GBM with IDH-wt and IDH-mut were compared. The diagnostic accuracy for distinguishing gliomas with IDH-wt from those with IDH-mut was assessed using receiver operating characteristic (ROC) curve analysis of the mean T/N ratios for the 3 PET tracers.RESULTSThere were significant differences in the mean T/N ratios for all 3 PET tracers between the IDH-wt and IDH-mut groups of all histological classifications (p < 0.001). Among the 27 gliomas with mean T/N ratios higher than the cutoff values for all 3 PET tracers, 23 (85.2%) were classified into the IDH-wt group using ROC analysis. In DA, there were no significant differences in the T/N ratios for MET, CHO, and FDG between the IDH-wt and IDH-mut groups. In AA, the mean T/N ratios of all 3 PET tracers in the IDH-wt group were significantly higher than those in the IDH-mut group (p < 0.01). In GBM, the mean T/N ratio in the IDH-wt group was significantly higher than that in the IDH-mut group for both MET (p = 0.034) and CHO (p = 0.01). However, there was no significant difference in the ratio for FDG.CONCLUSIONSPET imaging using MET, CHO, and FDG was suggested to be informative for preoperatively differentiating gliomas according to the 2016 WHO classification, particularly for differentiating IDH-wt and IDH-mut tumors.

PET Tracers for Imaging of ABC Transporters at the Blood-Brain Barrier: Principles and Strategies

2016 ◽  
Vol 22 (38) ◽  
pp. 5779-5785 ◽  
Author(s):  
Gert Luurtsema ◽  
Philip Elsinga ◽  
Rudi Dierckx ◽  
Ronald Boellaard ◽  
Aren Waarde
Keyword(s):  
Blood Brain Barrier ◽  
Abc Transporters ◽  
Brain Barrier ◽  
Pet Tracers ◽  
Blood Brain
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