Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

2005 ◽  
pp. 4764 ◽  
Author(s):  
Yaw Kai Yan ◽  
Michael Melchart ◽  
Abraha Habtemariam ◽  
Peter J. Sadler
Keyword(s):  
Organometallic Chemistry ◽  
Anticancer Complexes ◽  
Ruthenium Arene

Organometallic Chemistry, Biology and Medicine: Ruthenium Arene Anticancer Complexes

ChemInform ◽  
2006 ◽  
Vol 37 (4) ◽  
Author(s):  
Yaw Kai Yan ◽  
Michael Melchart ◽  
Abraha Habtemariam ◽  
Peter J. Sadler
Keyword(s):  
Organometallic Chemistry ◽  
Anticancer Complexes ◽  
Ruthenium Arene

Ruthenium Arene Anticancer Complexes

2006 ◽  
pp. 39-64 ◽  
Author(s):  
Michael Melchart ◽  
Peter J. Sadler
Keyword(s):  
Anticancer Complexes ◽  
Ruthenium Arene

Transcription Inhibition by Organometallic Ruthenium - Arene Anticancer Complexes in Live Mammalian Cells

2012 ◽  
Vol 65 (9) ◽  
pp. 1271 ◽  
Author(s):  
Astrid Astarina ◽  
Mun Juinn Chow ◽  
Wee Han Ang
Keyword(s):  
Anticancer Agents ◽  
Mammalian Cells ◽  
Transcription Inhibition ◽  
Biological Targets ◽  
Arene Ligands ◽  
Arene Ligand ◽  
Anticancer Complexes ◽  
Covalent Adducts ◽  
The Spectator ◽  
Ruthenium Arene

Organometallic ruthenium–arene RAPTA complexes, currently being actively pursued as potential anticancer agents, interact with intracellular biological targets to form covalent adducts. Because their mode of action is still unclear, we investigated their binding with DNA and the ability of ruthenated-DNA adducts to elicit cellular responses such as transcription inhibition and repair. To investigate the influence of the spectator arene ligands on RAPTA activity, a novel RAPTA complex containing the bulky 1,3,5-triisopropylbenzene ligand was synthesized and characterized. Transcription experiments carried out in live mammalian cells using ruthenated plasmid probes revealed that increasing steric bulk of the arene ligand did not improve its ability to arrest transcription.

Naphthalimide-Tagged Ruthenium–Arene Anticancer Complexes: Combining Coordination with Intercalation

2012 ◽  
Vol 31 (20) ◽  
pp. 7031-7039 ◽  
Author(s):  
Kelly J. Kilpin ◽  
Catherine M. Clavel ◽  
Fabio Edafe ◽  
Paul J. Dyson
Keyword(s):  
Anticancer Complexes ◽  
Ruthenium Arene

A comparative study on interactions of cisplatin and ruthenium arene anticancer complexes with metallothionein using MALDI-TOF-MS

2011 ◽  
Vol 307 (1-3) ◽  
pp. 79-84 ◽  
Author(s):  
Guangxue Zhang ◽  
Wenbing Hu ◽  
Zhifeng Du ◽  
Shuang Lv ◽  
Wei Zheng ◽  
...  
Keyword(s):  
Comparative Study ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Anticancer Complexes ◽  
Ruthenium Arene ◽  
Tof Ms

Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue

Metallomics ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 546-555 ◽  
Author(s):  
Yu Lin ◽  
Jie Wang ◽  
Wei Zheng ◽  
Qun Luo ◽  
Kui Wu ◽  
...  
Keyword(s):  
Disulfide Bond ◽  
Cysteine Residue ◽  
Catalytic Cysteine ◽  
Anticancer Complexes ◽  
Ruthenium Arene ◽  
Peroxiredoxin I

Ruthenium arene anticancer complexes bind to human peroxiredoxin I, leading to oxidation of thiolate and failure of forming a disulfide bond.

scholarly journals Contrasting cellular uptake pathways for chlorido and iodido iminopyridine ruthenium arene anticancer complexes

Metallomics ◽  
2012 ◽  
Vol 4 (12) ◽  
pp. 1271 ◽  
Author(s):  
Isolda Romero-Canelón ◽  
Ana M. Pizarro ◽  
Abraha Habtemariam ◽  
Peter J. Sadler
Keyword(s):  
Cellular Uptake ◽  
Anticancer Complexes ◽  
Ruthenium Arene
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