Solid-phase synthesis, characterization and DNA binding properties of the first chloro(polypyridyl)ruthenium conjugated peptide complex

2005 ◽  
pp. 728 ◽  
Author(s):  
Konstantina Karidi ◽  
Achilleas Garoufis ◽  
Nick Hadjiliadis ◽  
Jan Reedijk
Keyword(s):  
Dna Binding ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Binding Properties ◽  
Phase Synthesis ◽  
Peptide Complex ◽  
Dna Binding Properties

Solid-Phase Synthesis of DNA Binding Polyamides on Oxime Resin

2002 ◽  
Vol 10 (8) ◽  
pp. 2767-2774 ◽  
Author(s):  
J.M Belitsky ◽  
D.H Nguyen ◽  
N.R Wurtz ◽  
Peter B Dervan
Keyword(s):  
Dna Binding ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis

Solid-phase synthesis of new pyrrolobenzodiazepine–chalcone conjugates: DNA-binding affinity and anticancer activity

2008 ◽  
Vol 18 (7) ◽  
pp. 2434-2439 ◽  
Author(s):  
Ahmed Kamal ◽  
N. Shankaraiah ◽  
S. Prabhakar ◽  
Ch. Ratna Reddy ◽  
N. Markandeya ◽  
...  
Keyword(s):  
Dna Binding ◽  
Anticancer Activity ◽  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Dna Binding Affinity

scholarly journals Effect of Polymerization Time on the Binding Properties of Ciprofloxacin-Imprinted nanoMIPs Prepared by Solid-Phase Synthesis

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2656
Author(s):  
Matteo Charello ◽  
Laura Anfossi ◽  
Simone Cavalera ◽  
Fabio Di Nardo ◽  
Fiora Artusio ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Polymer Chains ◽  
Polymerization Time ◽  
Dissociation Kinetics ◽  
Binding Properties ◽  
Phase Synthesis ◽  
High Binding ◽  
High Binding Affinity

An innovative approach to imprinted nanoparticles (nanoMIPs) is represented by solid-phase synthesis. Since the polymeric chains grow over time and rearrange themselves around the template, the binding properties of nanoMIPs could depend on the polymerization time. Here we present an explorative study about the effect of different polymerization times on the binding properties of ciprofloxacin-imprinted nanoMIPs. The binding properties towards ciprofloxacin were studied by measuring the binding affinity constants (Keq) and the kinetic rate constants (kd, ka). Furthermore, selectivity and nonspecific binding were valued by measuring the rebinding of levofloxacin onto ciprofloxacin-imprinted nanoMIPs and ciprofloxacin onto diclofenac-imprinted nanoMIPs, respectively. The results show that different polymerization times produce nanoMIPs with different binding properties: short polymerization times (15 min) produced nanoMIPs with high binding affinity but low selectivity (Keq > 107 mol L−1, α ≈ 1); medium polymerization times (30 min–2 h) produced nanoMIPs with high binding affinity and selectivity (Keq ≥ 106 mol L−1, α < 1); and long polymerization times (>2 h) produced nanoMIPs with low binding affinity, fast dissociation kinetics and low selectivity (Keq ≤ 106 mol L−1, kdis > 0.2 min−1, α ≈ 1). The results can be explained as the combined effect of rearrangement and progressive stiffening of the polymer chains around the template molecules.

Solid-phase synthesis of amidine-substituted phenylbenzimidazoles and incorporation of this DNA binding and recognition motif into amino acid and peptide conjugates

Amino Acids ◽  
2014 ◽  
Vol 46 (5) ◽  
pp. 1297-1303
Author(s):  
Matthew L. Garner ◽  
Taxiarchis M. Georgiadis ◽  
Jessica Bo Li ◽  
Tianxiu Wang ◽  
Eric C. Long
Keyword(s):  
Amino Acid ◽  
Dna Binding ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Peptide Conjugates ◽  
Phase Synthesis ◽  
Recognition Motif
Sign in / Sign up

Export Citation Format

Share Document