Carbon–carbon bond formation by radical addition–fragmentation reactions of O-alkylated enols

2004 ◽  
Vol 2 (17) ◽  
pp. 2517-2529 ◽  
Author(s):  
Yudong Cai ◽  
Brian P. Roberts ◽  
Derek A. Tocher ◽  
Sarah A. Barnett
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Fragmentation Reactions

Carbon?Carbon Bond Formation by Radical Addition?Fragmentation Reactions of O-Alkylated Enols.

ChemInform ◽  
2005 ◽  
Vol 36 (5) ◽  
Author(s):  
Yudong Cai ◽  
Brian P. Roberts ◽  
Derek A. Tocher ◽  
Sarah A. Barnett
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Fragmentation Reactions

Alkylative amination of aldehydes via carbon-carbon bond formation based on radical addition to carbon-nitrogen double bond

Tetrahedron ◽  
1999 ◽  
Vol 55 (37) ◽  
pp. 11209-11218 ◽  
Author(s):  
Hideto Miyabe ◽  
Kumiko Yamakawa ◽  
Naoko Yoshioka ◽  
Takeaki Naito
Keyword(s):  
Double Bond ◽  
Bond Formation ◽  
Radical Addition ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Nitrogen Double Bond

ChemInform Abstract: Carbon-Carbon Bond Formation via Intermolecular Carbon Radical Addition to Aldoxime Ethers.

ChemInform ◽  
2010 ◽  
Vol 29 (18) ◽  
pp. no-no
Author(s):  
H. MIYABE ◽  
R. SHIBATA ◽  
C. USHIRO ◽  
T. NAITO
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Carbon Bond ◽  
Carbon Carbon Bond

Carboncarbon bond formation via intermolecular carbon radical addition to aldoxime ethers

1998 ◽  
Vol 39 (7) ◽  
pp. 631-634 ◽  
Author(s):  
Hideto Miyabe ◽  
Ryouhei Shibata ◽  
Chikage Ushiro ◽  
Takeaki Naito
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Carbon Bond ◽  
Carbon Carbon Bond

Carbon–carbon bond formation by radical addition of α-trifluoromethylacrylate with cyclic ethers

2008 ◽  
Vol 129 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Akihiro Hosoya ◽  
Youhei Umino ◽  
Tadashi Narita ◽  
Hiroshi Hamana
Keyword(s):  
Bond Formation ◽  
Radical Addition ◽  
Cyclic Ethers ◽  
Carbon Bond ◽  
Carbon Carbon Bond

Carbon Dioxide-Mediated C(sp2)–H Arylation of Primary and Secondary Benzylamines

2018 ◽  
Author(s):  
Mohit Kapoor ◽  
Pratibha Chand-Thakuri ◽  
Michael Young
Keyword(s):  
Carbon Dioxide ◽  
Transition Metal ◽  
Bond Activation ◽  
Bond Formation ◽  
Carbon Bond ◽  
Chelate Effect ◽  
Free Amine ◽  
Carbon Carbon Bond ◽  
New Strategy ◽  
Metal Catalyzed

Carbon-carbon bond formation by transition metal-catalyzed C–H activation has become an important strategy to fabricate new bonds in a rapid fashion. Despite the pharmacological importance of <i>ortho</i>-arylbenzylamines, however, effective <i>ortho</i>-C–C bond formation from C–H bond activation of free primary and secondary benzylamines using Pd<sup>II</sup> remains an outstanding challenge. Presented herein is a new strategy for constructing <i>ortho</i>-arylated primary and secondary benzylamines mediated by carbon dioxide (CO<sub>2</sub>). The use of CO<sub>2</sub> is critical to allowing this transformation to proceed under milder conditions than previously reported, and that are necessary to furnish free amine products that can be directly used or elaborated without the need for deprotection. In cases where diarylation is possible, a chelate effect is demonstrated to facilitate selective monoarylation.

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