A novel crownophane trapping CO2 as carbonic acid at room temperatureElectronic supplementary information (ESI) available: synthesis of compounds, 2 ? 4, and the data of their 1H NMR, IR, ESI mass spectra and elemental analysis, and the charts of IR spectrum and DTA and TGA thermograms of the solids separated out after bubbling CO2. See http://www.rsc.org/suppdata/cc/b4/b403152k/

2004 ◽  
pp. 1474 ◽  
Author(s):  
Kazuhisa Hiratani ◽  
Nobuko Sakamoto ◽  
Naohiro Kameta ◽  
Michinori Karikomi ◽  
Yoshinobu Nagawa
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Ir Spectrum ◽  
Mass Spectra ◽  
Carbonic Acid ◽  
Supplementary Information

Synthesis and Anticonvulsant Activity of 3-(alkylamino, alkoxy)-1,3,4,5- Tetrahydro-2H-benzo [b] azepine-2-one Derivatives

2018 ◽  
Vol 17 (6) ◽  
pp. 448-457 ◽  
Author(s):  
Xia Huang ◽  
Tie Chen ◽  
Rong-Bi Han ◽  
Feng-Yu Piao
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
13C Nmr ◽  
Anticonvulsant Activity ◽  
Mass Spectra ◽  
Maximal Electroshock ◽  
Test Compound ◽  
Maximal Electroshock Test ◽  
Mes Test ◽  
Structure Activity

Background & Objective: A series of novel 3-Substituted-1,3,4,5-Tetrahydro-2H-benzo [b] azepine-2-one Derivatives (4, 5, 7, 10, 12, 5a-j, 8a-e) were synthesized from 1,2,3,4-Tetrahydro-1- naphthalenone. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, MASS spectra and elemental analysis. Their anticonvulsant activity was evaluated by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity test. Compound 4 showed the maximum anticonvulsant activity against the maximal electroshock test (ED50=26.4, PI =3.2) and against the subcutaneous pentylenetetrazol test (ED50=40.2, PI =2.1). Conclusion: Possible structure-activity relationship was discussed.

scholarly journals Synthesis of Chlorinated 3,5 Diaryl 2 Pyrazrolines

2021 ◽  
pp. 476-479
Author(s):  
Pratiksha S. Rathod ◽  
Shilpa G. Chavan
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Heterocyclic Compounds ◽  
Mass Spectra ◽  
Biological Activities ◽  
Research Activity ◽  
Biological Screening ◽  
Pharmaceutical Applications

Pyrazolines are important nitrogen containing 5-membered heterocyclic compounds. Various, pyrazoline derivatives have been found to possess considerable biological and pharmaceutical applications as activities, which stimulated the research activity in this field. The chlorinated 3,5-diary-l-2-pyrazolines has been synthesized by reaction of appropriately substituted chloro chalcones and mono-substituted hydrazine’s have been synthesized. These compounds were characterized using IR, 1H-NMR and Mass spectra and Elemental analysis. They possess some potent biological activities. Therefore, biological screening of novel compounds has been also done.

scholarly journals Tetracyclic Heteroaromatic Systems-Synthesis of Ethoxycarbonylphenylpyrido[3',2':5,6] Thiopyranoquinolines

2021 ◽  
Vol 64 (3) ◽  
pp. 191-194
Author(s):  
Muhammad Naeem Khan ◽  
Misbahul Ain Khan ◽  
Noreen Aslam ◽  
Pir Bakhsh Khan ◽  
Ehsan ul Haq
Keyword(s):  
1H Nmr ◽  
Elemental Analysis ◽  
Mass Spectra ◽  
Ethyl Pyruvate ◽  
Analysis Data ◽  
Elemental Analysis Data

7-benzylideneamino-5H-thiochromeno[2,3-b]pyridin-5-ones and 9-benzylideneamino-5H-thio- chromeno[2,3-b]pyridin-5-ones, on reaction with ethyl pyruvate to afford 1-ethoxycarbonyl-3-phenyl-12H- pyrido[3',2':5,6]thiopyrano[3,2-f]quinoline-12-ones and 4-ethoxycarbonyl-2-phenyl-7H- pyrido[3',2':5,6]thiopyrano[3,2-h]quinoline-7-ones respectively by the two different methods. These products were precipitated by addition of ethanol, water (1:1), were purified by recrystalizing from appropriate solvents and were characterized from their IR, 1H-NMR, mass spectra and elemental analysis data.  

scholarly journals SYNTHESIS OF 2-(3-CHROMENYL)-4-ETHOXYCARBONYL-1-(4-FLUOROBENZYL)-5-METHYLIMIDAZOLE 3-OXIDES

2017 ◽  
Vol 60 (2) ◽  
pp. 17
Author(s):  
Vladislav I. Razgulyaev ◽  
Polina A. Nikitina ◽  
Tatiana Yu. Koldaeva ◽  
Vladimir S. Miroshnikov ◽  
Valery P. Perevalov
Keyword(s):  
1H Nmr ◽  
Ir Spectrum ◽  
Mass Spectra ◽  
Broad Band ◽  
Imidazole Ring ◽  
Molecular Ions ◽  
Carbonyl Groups ◽  
Absorption Bands ◽  
Ester Moiety ◽  
Hiv 1

In addition to our search for probable HIV-1 integrase inhibitors in the series of imidazole derivatives a possibility of preparation of 2-(3-chromenyl)substituted imidazole 3-oxides containing fluorobenzyl moiety in position 1 of imidazole ring as a potential pharmacophore was demonstrated. 4-ethoxycarbonyl-1-(4-fluorobenzyl)-5-methyl-2-(4-oxo-4H-chromen-3-yl)imidazole 3-oxide 4a and 4-ethoxycarbonyl-2-(6-hydroxy-4-oxo-4H-chromen-3-yl)-1-(4-fluorobenzyl)-5-methyli-midazole 3-oxide 4b were synthesized starting with fluorobenzylamine 1, ethyl 2-(hydroxyimino)-3-oxobutanoate 2 and 4-oxo-4H-chromen-3-carbaldehyde 3a or 6-hydroxy-4-oxo-4H-chromen-3-carbaldehyde 3b, respectively. The condensation was carried out at room temperature in glacial acetic acid. Two novel imidazole N-oxides were characterized by 1H NMR and IR spectroscopy and mass-spectrometry. It should be noted that in 1H NMR spectra of the discussed imidazole N-oxides (recorded in deuterated DMSO) the singlet of the proton in the position 2 of chromenyl ring is shifted to lower field (8.70 and 8.78, respectively) as compared with the signals of other aromatic protons. Such deshielding is typical for this kind of heterocyclic system and may be explained by the influence of the electron-withdrawing of N-oxide moiety. In the IR spectrum of 4-ethoxycarbonyl-1-(4-fluorobenzyl)-5-methyl-2-(4-oxo-4H-chromen-3-yl)imidazole 3-oxide 4a the absorption bands corresponding to the carbonyl groups appear at 1641 cm-1 (for C=O in the position 4 of chromenyl ring) and 1641 cm-1 (C=O of the ester moiety). In the IR spectrum of 4-ethoxycarbonyl-2-(6-hydroxy-4-oxo-4H-chromen-3-yl)-1-(4-fluorobenzyl)-5-methylimidazole 3-oxide 4b the position of the former band remains practically unchanged (1646 cm-1), whereas the latter band is shifted to higher frequencies (1715 cm-1) due to intermolecular interactions with OH-group in the position 6 of the chromene. The absorption band for this group appears as a broad band with medium intensity and maximum absorption at 3228 cm-1. In the mass spectra of imidazole N-oxides under consideration peaks of the molecular ions (M+) and peaks (M-16) are observed. The demonstrated possibility of the synthesis of the titled compounds allows the further planning of the synthesis of a series of such structures varying the substituents in both chromenyl and imidazole rings. Forcitation:Razgulyaev V.I., Nikitina P.A., Koldaeva T.Yu., Miroshnikov V.S., Perevalov V.P. Synthesisof  2-(3-chromenyl)-4-ethoxycarbo-nyl-1-(4-fluorobenzyl)-5-methylimidazole 3-oxides. Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol. 2017. V. 60. N 2. P. 17-19.

Sign in / Sign up

Export Citation Format

Share Document