Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptidesElectronic supplementary information (ESI) available: experimental procedures, procedures of biological assays, Table S1: characterization data of novel synthetic compounds and HPLC chromatograms for 10E,10K and 10L. See http://www.rsc.org/suppdata/ob/b4/b401485p/

2004 ◽  
Vol 2 (8) ◽  
pp. 1255 ◽  
Author(s):  
Hirokazu Tamamura ◽  
Makiko Mizumoto ◽  
Kenichi Hiramatsu ◽  
Shuichi Kusano ◽  
Shigemi Terakubo ◽  
...  
Keyword(s):  
Supplementary Information ◽  
Synthetic Compounds ◽  
Biological Assays

THE CHEMISTRY OF VITAMIN E. II. BIOLOGICAL ASSAYS OF VARIOUS SYNTHETIC COMPOUNDS

Science ◽  
1938 ◽  
Vol 88 (2271) ◽  
pp. 38-39 ◽  
Author(s):  
H. M. Evans ◽  
G. A. Emerson ◽  
O. H. Emerson
Keyword(s):  
Vitamin E ◽  
Synthetic Compounds ◽  
Biological Assays

Structural similarity of ribosomes from E. coli and A. salina

1978 ◽  
Vol 36 (2) ◽  
pp. 242-243
Author(s):  
M. Boublik ◽  
R.M. Wydro ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Ribosomal Proteins ◽  
Direct Evidence ◽  
Structural Similarity ◽  
Carbon Support ◽  
Artemia Salina ◽  
Uranyl Acetate ◽  
Biological Assays ◽  
E Coli ◽  
And Function ◽  
Fine Carbon

Ribosomes are ribonucleoprotein particles necessary for processing the genetic information of mRNA into proteins. Analogy in composition and function of ribosomes from diverse species, established by biochemical and biological assays, implies their structural similarity. Direct evidence obtained by electron microscopy seems to be of increasing relevance in understanding the structure of ribosomes and the mechanism of their role in protein synthesis.The extent of the structural homology between prokaryotic and eukaryotic ribosomes has been studied on ribosomes of Escherichia coli (E.c.) and Artemia salina (A.s.). Despite the established differences in size and in the amount and proportion of ribosomal proteins and RNAs both types of ribosomes show an overall similarity. The monosomes (stained with 0.5% aqueous uranyl acetate and deposited on a fine carbon support) appear in the electron micrographs as round particles with a diameter of approximately 225Å for the 70S E.c. (Fig. 1) and 260Å for the 80S A.s. monosome (Fig. 2).

Zone-axis ALCHEMI for the rapid assessment of site occupancies in garnets

1986 ◽  
Vol 44 ◽  
pp. 706-707
Author(s):  
M.T. Otten ◽  
P.R. Buseck
Keyword(s):  
Single Crystals ◽  
Rapid Assessment ◽  
Site Occupancy ◽  
Zone Axis ◽  
Synthetic Compounds ◽  
X Ray ◽  
Large Group ◽  
Crystallographic Planes

ALCHEMI (Atom Location by CHannelling-Enhanced Microanalysis) is a TEM technique for determining site occupancies in single crystals. The method uses the channelling of incident electrons along specific crystallographic planes. This channelling results in enhanced x-ray emission from the atoms on those planes, thereby providing the required site-occupancy information. ALCHEMI has been applied with success to spinel, olivine and feldspar. For the garnets, which form a large group of important minerals and synthetic compounds, the channelling effect is weaker, and significant results are more difficult to obtain. It was found, however, that the channelling effect is pronounced for low-index zone-axis orientations, yielding a method for assessing site occupancies that is rapid and easy to perform.

The Effects of Some Synthetic Compounds on In Vitro Fibrinolytic Activity Measured by Different Methods and the Relevance to Activity In Vivo

1972 ◽  
Vol 28 (03) ◽  
pp. 351-358
Author(s):  
A.J Baillie ◽  
A. K Sim
Keyword(s):  
Inhibitory Activity ◽  
Substrate Concentration ◽  
Fibrinolytic Activity ◽  
Synthetic Compounds ◽  
In Vitro Methods ◽  
Narrow Concentration Range

SummaryThe activity of several synthetic compounds, rated from good to poor (or inactive) fibrinolytic activators, has been assessed by two different commonly-used in vitro methods. Compounds shown to be active over a narrow concentration range in the hanging clot test were shown to be inhibitors of plasmin and trypsin in the casein-olytic test. The inhibitory activity of these compounds was shown to increase with increasing substrate concentration and apparent activity in the hanging clot test. Possible explanations and relevance of these observations are discussed.

On the morphosyntax of synthetic compounds with proper names: A case study on the diachrony of Greek

2020 ◽  
Vol 13 (2) ◽  
pp. 189-210
Author(s):  
Artemis Alexiadou
Keyword(s):  
Proper Names ◽  
Synthetic Compounds ◽  
Modern Language ◽  
Modern Greek

This paper discusses the formation of synthetic compounds with proper names. While these are possible in English, Greek disallows such formations. However, earlier stages of the language allowed such compounds, and in the modern language formations of this type are possible as long as they contain heads that are either bound roots or root- derived nominals of Classical Greek origin. The paper builds on the following ingredients: a) proper names are phrases; b) synthetic compounding in Modern Greek involves incorporation, and thus proper names cannot incorporate; c) by contrast, English synthetic compounds involve phrasal movement, and thus proper names can appear within compounds in this language. It is shown that in earlier Greek, proper names had the same status as their English counterparts, hence the possibility of synthetic compounds with proper names. It is further argued that the formations that involve bound/archaic roots are actually cases of either root compounding or root affixation and not synthetic compounds.

Anacyclamide D8P, a prenylated cyanobactin from a Sphaerospermopsis sp. cyanobacterium

2017 ◽  
Author(s):  
Joana Martins ◽  
Niina Leikoski ◽  
Matti Wahlsten ◽  
Joana Azevedo ◽  
Jorge Antunes ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Cyclic Peptides ◽  
Biosynthetic Gene Cluster ◽  
The Novel ◽  
Tyrosine Residue ◽  
Biosynthetic Gene ◽  
Post Translational Modification ◽  
Biological Assays ◽  
Mass Spectrometric Data ◽  
Spectrometric Data

Cyanobactins are a family of linear and cyclic peptides produced through the post-translational modification of short precursor peptides. Anacyclamides are macrocyclic cyanobactins with a highly diverse sequence that are common in the genus <i>Anabaena</i>. A mass spectrometry-based screening of potential cyanobactin producers led to the discovery of a new prenylated member of this family of compounds, anacyclamide D8P (<b>1</b>), from <i>Sphaerospermopsis</i> sp. LEGE 00249. The anacyclamide biosynthetic gene cluster (<i>acy</i>) encoding the novel macrocyclic prenylated cyanobactin, was sequenced. Heterologous expression of the acy gene cluster in <i>Escherichia</i> <i>coli</i> established the connection between genomic and mass spectrometric data. Unambiguous establishment of the type and site of prenylation required the full structural elucidation of <b>1</b> using Nuclear Magnetic Resonance (NMR), which demonstrated that a forward prenylation occurred on the tyrosine residue. Compound <b>1</b> was tested in pharmacologically or ecologically relevant biological assays and revealed moderate antimicrobial activity towards the fouling bacterium <i>Halomonas aquamarina</i> CECT 5000.<br>

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