Structural flexibility of formally d10 [M(biphosphinine)2]q complexesElectronic supplementary information (ESI) available: main geometrical parameters optimized for the structures whose energies are reported in Fig. 1. See http://www.rsc.org/suppdata/nj/b3/b316684h/

2004 ◽  
Vol 28 (7) ◽  
pp. 838 ◽  
Author(s):  
Hadrien Perron ◽  
Audrey Moores ◽  
Isabelle Demachy ◽  
Agusti Lledos ◽  
Yves Jean ◽  
...  
Keyword(s):  
Supplementary Information ◽  
Geometrical Parameters ◽  
Structural Flexibility

scholarly journals Solubility-Weighted Index: fast and accurate prediction of protein solubility

2020 ◽  
Vol 36 (18) ◽  
pp. 4691-4698 ◽  
Author(s):  
Bikash K Bhandari ◽  
Paul P Gardner ◽  
Chun Shen Lim
Keyword(s):  
Protein Expression ◽  
Protein Production ◽  
Protein Solubility ◽  
Region Of Interest ◽  
Supplementary Information ◽  
Structural Flexibility ◽  
Web Interface ◽  
Solubility Prediction ◽  
Prediction Tools ◽  
Weighted Index

Abstract Motivation Recombinant protein production is a widely used technique in the biotechnology and biomedical industries, yet only a quarter of target proteins are soluble and can therefore be purified. Results We have discovered that global structural flexibility, which can be modeled by normalized B-factors, accurately predicts the solubility of 12 216 recombinant proteins expressed in Escherichia coli. We have optimized these B-factors, and derived a new set of values for solubility scoring that further improves prediction accuracy. We call this new predictor the ‘Solubility-Weighted Index’ (SWI). Importantly, SWI outperforms many existing protein solubility prediction tools. Furthermore, we have developed ‘SoDoPE’ (Soluble Domain for Protein Expression), a web interface that allows users to choose a protein region of interest for predicting and maximizing both protein expression and solubility. Availability and implementation The SoDoPE web server and source code are freely available at https://tisigner.com/sodope and https://github.com/Gardner-BinfLab/TISIGNER-ReactJS, respectively. The code and data for reproducing our analysis can be found at https://github.com/Gardner-BinfLab/SoDoPE_paper_2020. Supplementary information Supplementary data are available at Bioinformatics online.

Bulk drag coefficient of a subaquatic vegetation subjected to irregular waves: Influence of Reynolds and Keulegan-Carpenter numbers

2020 ◽  
pp. 34-42
Author(s):  
Thibault Chastel ◽  
Kevin Botten ◽  
Nathalie Durand ◽  
Nicole Goutal
Keyword(s):  
Drag Coefficient ◽  
Wave Height ◽  
Wave Attenuation ◽  
Empirical Relationship ◽  
Breaking Waves ◽  
Irregular Waves ◽  
Geometrical Parameters ◽  
Flume Experiments ◽  
Seagrass Meadows ◽  
Artificial Vegetation

Seagrass meadows are essential for protection of coastal erosion by damping wave and stabilizing the seabed. Seagrass are considered as a source of water resistance which modifies strongly the wave dynamics. As a part of EDF R & D seagrass restoration project in the Berre lagoon, we quantify the wave attenuation due to artificial vegetation distributed in a flume. Experiments have been conducted at Saint-Venant Hydraulics Laboratory wave flume (Chatou, France). We measure the wave damping with 13 resistive waves gauges along a distance L = 22.5 m for the “low” density and L = 12.15 m for the “high” density of vegetation mimics. A JONSWAP spectrum is used for the generation of irregular waves with significant wave height Hs ranging from 0.10 to 0.23 m and peak period Tp ranging from 1 to 3 s. Artificial vegetation is a model of Posidonia oceanica seagrass species represented by slightly flexible polypropylene shoots with 8 artificial leaves of 0.28 and 0.16 m height. Different hydrodynamics conditions (Hs, Tp, water depth hw) and geometrical parameters (submergence ratio α, shoot density N) have been tested to see their influence on wave attenuation. For a high submergence ratio (typically 0.7), the wave attenuation can reach 67% of the incident wave height whereas for a low submergence ratio (< 0.2) the wave attenuation is negligible. From each experiment, a bulk drag coefficient has been extracted following the energy dissipation model for irregular non-breaking waves developed by Mendez and Losada (2004). This model, based on the assumption that the energy loss over the species meadow is essentially due to the drag force, takes into account both wave and vegetation parameter. Finally, we found an empirical relationship for Cd depending on 2 dimensionless parameters: the Reynolds and Keulegan-Carpenter numbers. These relationships are compared with other similar studies.

Study of the process of forming a hole for a thread at manufacturing a high nut

2020 ◽  
Vol 76 (8) ◽  
pp. 841-846
Author(s):  
I. G. Shubin ◽  
A. A. Kurkin
Keyword(s):  
Metal Flow ◽  
Nonlinear Dependence ◽  
Geometrical Parameters ◽  
Relative Height ◽  
Forming Process ◽  
Normal Height ◽  
Accuracy Class ◽  
Limit Values ◽  
Program Complex ◽  
Class B

During manufacturing nuts of increased height, a problem of obtaining correct cylindrical form of the hole for thread and overall geometrical parameters arises. To solve the problem it is necessary to know regularity of the blank forming process. Results of the study of a technological process of high hexahedral nuts forming presented. The nuts were M18 of 22 mm height, M16 of 19 mm height and M12 of normal height 10 mm according to GOST 5915–70, accuracy class B, steel grade 10 according to GOST 10702–78. The volumetric stamping was accomplished at the five-position automatic presses of АА1822 type. It was determined, that unevenness of the metal flow in the process of plastic deformation of blanks of increased height nuts was caused by different stress conditions by their sections. To simulate the mode of deformation, the program complex QForm-3D was chosen. The complex ensured to forecast with necessary accuracy the metal flow in a blank, as well as to define the deformation force and arising stress in the working instrument. The simulation showed the presence of regularity between preliminary formed buffle and deviation of dimensions and form of a blank wall after its finishing piercing, which can be expressed by a nonlinear dependence. The limit values of the relative height of the buffle С/D = 0.56–0.588 defined, exceeding which will result in rejection of the finished product. Accounting the limit values of the relative height of the buffle will enable to correct a mode of technological operations and technological instruments at stamping of high hexahedral nuts.

Development of Hardware and Software for the System of Remote Control of Geometrical Parameters of Railcar Wheelsets

2017 ◽  
Vol 13 (2) ◽  
pp. 33-42
Author(s):  
Ye.V. Shapovalov ◽  
◽  
V.O. Koliada ◽  
D.D. Topchev ◽  
N.F. Lutsenko ◽  
...  
Keyword(s):  
Remote Control ◽  
Geometrical Parameters
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