The first general method for α-trifluoromethylation of carboxylic acids using BrF3

2004 ◽  
pp. 594-595 ◽  
Author(s):  
Aviv Hagooly ◽  
Shlomo Rozen
2020 ◽  
Author(s):  
Anthony Garcia ◽  
Matthew Leech ◽  
Alessia Petti ◽  
Camille Denis ◽  
Iain C. A. Goodall ◽  
...  

A new electrochemical methodology has been developed for the preparation of a wide variety of functionalised orthoesters under mild and green conditions from easily accessible dithiane derivatives. The new methodology also offers an unprecedented way to access tri(fluorinated) orthoesters, a class of compound that has never been studied before. This provides the community with a rapid and general method to prepare libraries of functionalised orthoesters from simple and readily available starting materials.


2020 ◽  
Vol 85 (7) ◽  
pp. 5019-5026 ◽  
Author(s):  
Shah Nawaz Khan ◽  
Muhammad Kashif Zaman ◽  
Ruining Li ◽  
Zhankui Sun

Synthesis ◽  
2007 ◽  
Vol 2007 (22) ◽  
pp. 3489-3496 ◽  
Author(s):  
Giuseppe Bartoli ◽  
Marcella Bosco ◽  
Armando Carlone ◽  
Renato Dalpozzo ◽  
Enrico Marcantoni ◽  
...  

1995 ◽  
Vol 60 (9) ◽  
pp. 2792-2795 ◽  
Author(s):  
Juyoung Yoon ◽  
Sungyeap Hong ◽  
Kristy A. Martin ◽  
Anthony W. Czarnik

1965 ◽  
Vol 18 (7) ◽  
pp. 1023 ◽  
Author(s):  
ALJ Beckwith ◽  
JE Goodrich

Various branched-chain carboxylic acids have been oxidized with the following reagents: (A) potassium manganate in dilute alkali; (B) potassium permanganate in concentrated alkali; (C) potassium peroxydisulphate in dilute alkali; (D) potassium peroxydisulphate in dilute acid. In most cases hydroxy-acids were formed by oxidation at the tertiary position but the yields were poor. None of these reagents appears to provide a general method for the preparation of lactones from branched-chain saturated carboxylic acids.


1993 ◽  
Vol 34 (39) ◽  
pp. 6317-6320 ◽  
Author(s):  
Jesús Ezquerra ◽  
Concepción Pedregal ◽  
Almudena Rubio ◽  
Jesús Valenciano ◽  
José Luis García Navio ◽  
...  

Synthesis ◽  
2017 ◽  
Vol 49 (16) ◽  
pp. 3692-3699 ◽  
Author(s):  
Asim Debnath ◽  
Dmitry Belov ◽  
Vladimir Ivanov ◽  
Francesca Curreli ◽  
Alexander Kurkin ◽  
...  

5-Arylpyrrole-2-carboxylic acids are important key intermediates in the synthesis of HIV-1 entry inhibitors (such as NBD-11021 and NBD-14010). Here we present a general method for the synthesis of some 5-arylpyrrole-2-carboxylic acids in three steps starting from pyrrole. By this method, the compounds could be prepared on gram scale and without chromatographic purification.


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