Discovery and evaluation of highly active imidotitanium ethylene polymerisation catalysts using high throughput catalyst screening

2004 ◽  
pp. 434-435 ◽  
Author(s):  
Nico Adams ◽  
Henricus J. Arts ◽  
Paul D. Bolton ◽  
Dan Cowell ◽  
Stuart R. Dubberley ◽  
...  
Keyword(s):  
High Throughput ◽  
Highly Active ◽  
Catalyst Screening ◽  
Ethylene Polymerisation

scholarly journals Pushing Nanomaterials past the Kilogram Scale—a Targeted Approach Integrating Scalable Microreactors, Machine Learning and High-Throughput Analysis

2020 ◽  
Author(s):  
Nicholas Jose ◽  
mikhail Kovalev ◽  
Eric Bradford ◽  
Artur Schweidtmann ◽  
Hua Chun Zeng ◽  
...  
Keyword(s):  
Machine Learning ◽  
High Throughput ◽  
Scale Up ◽  
Process Efficiency ◽  
High Yield ◽  
Synthesis Methods ◽  
High Throughput Analysis ◽  
Throughput Analysis ◽  
Highly Active ◽  
Technological Advances

Novel materials are the backbone of major technological advances. However, the development and wide-scale introduction of new materials, such as nanomaterials, is limited by three main factors—the expense of experiments, inefficiency of synthesis methods and complexity of scale-up. Reaching the kilogram scale is a hurdle that takes years of effort for many nanomaterials. We introduce an improved methodology for materials development, combining state-of-the-art techniques—multi-objective machine learning optimization, high yield microreactors and high throughput analysis. We demonstrate this approach by efficiently developing a kg per day reaction process for highly active antibacterial ZnO nanoparticles. The proposed method has the potential to significantly reduce experimental costs, increase process efficiency and enhance material performance, which culminate to form a new pathway for materials discovery.

Highly Active, Thermally Stable, Ethylene-Polymerisation Pre-Catalysts Based on Niobium/TantalumImine Systems

2013 ◽  
Vol 19 (27) ◽  
pp. 8884-8899 ◽  
Author(s):  
Carl Redshaw ◽  
Mark Walton ◽  
Lucy Clowes ◽  
David L. Hughes ◽  
Anna-Marie Fuller ◽  
...  
Keyword(s):  
Thermally Stable ◽  
Highly Active ◽  
Ethylene Polymerisation

scholarly journals High-Throughput Screening of a 100,000-Compound Library for Inhibitors of Influenza A Virus (H3N2)

2008 ◽  
Vol 13 (9) ◽  
pp. 879-887 ◽  
Author(s):  
William E. Severson ◽  
Michael McDowell ◽  
Subramaniam Ananthan ◽  
Dong-Hoon Chung ◽  
Lynn Rasmussen ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Influenza A ◽  
Moderate Activity ◽  
Compound Library ◽  
Highly Active ◽  
Virus Life Cycle ◽  
Influenza Activity ◽  
Compound Concentration ◽  
Viral Cytopathic Effect

Using a highly reproducible and robust cell-based high-throughput screening (HTS) assay, the authors screened a 100,000-compound library at 14- and 114-µM compound concentration against influenza strain A/Udorn/72 (H3N2). The “hit” rates (>50% inhibition of the viral cytopathic effect) from the 14- and 114-µM screens were 0.022% and 0.38%, respectively. The hits were evaluated for their antiviral activity, cell toxicity, and selectivity in dose-response experiments. The screen at the lower concentration yielded 3 compounds, which displayed moderate activity (SI50 = 10-49). Intriguingly, the screen at the higher concentration revealed several additional hits. Two of these hits were highly active with an SI50 > 50. Time of addition experiments revealed 1 compound that inhibited early and 4 other compounds that inhibited late in the virus life cycle, suggesting they affect entry and replication, respectively. The active compounds represent several different classes of molecules such as carboxanilides, 1-benzoyl-3-arylthioureas, sulfonamides, and benzothiazinones, which have not been previously identified as having antiviral/anti-influenza activity. ( Journal of Biomolecular Screening 2008:879-887)

scholarly journals A Fluorescence-based High Throughput-Screening assay for the SARS-CoV RNA synthesis complex

2020 ◽  
Author(s):  
Cecilia Eydoux ◽  
Veronique Fattorini ◽  
Ashleigh Shannon ◽  
Thi-Tuyet-Nhung Le ◽  
Bruno Didier ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
High Throughput ◽  
High Throughput Screening ◽  
Rna Synthesis ◽  
Drug Repositioning ◽  
List Type ◽  
Emerging Viruses ◽  
Screening Assay ◽  
Highly Active ◽  
High Throughput Screening Assay

AbstractThe Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) emergence in 2003 introduced the first serious human coronavirus pathogen to an unprepared world. To control emerging viruses, existing successful anti(retro)viral therapies can inspire antiviral strategies, as conserved viral enzymes (eg., viral proteases and RNA-dependent RNA polymerases) represent targets of choice. Since 2003, much effort has been expended in the characterization of the SARS-CoV replication/transcription machinery. Until recently, a pure and highly active preparation of SARS-CoV recombinant RNA synthesis machinery was not available, impeding target-based high throughput screening of drug candidates against this viral family. The current Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) pandemic revealed a new pathogen whose RNA synthesis machinery is highly (>96% aa identity) homologous to SARS-CoV. This phylogenetic relatedness highlights the potential use of conserved replication enzymes to discover inhibitors against this significant pathogen, which in turn, contributes to scientific preparedness against emerging viruses. Here, we report the use of a purified and highly active SARS-CoV replication/transcription complex (RTC) to set-up a high-throughput screening of Coronavirus RNA synthesis inhibitors. The screening of a small (1,520 compounds) chemical library of FDA-approved drugs demonstrates the robustness of our assay and will allow to speed-up drug repositioning or novel drug discovery against the SARS-CoV-2.Principle of SARS-CoV RNA synthesis detection by a fluorescence-based high throughput screening assayHighlights- A new SARS-CoV non radioactive RNA polymerase assay is described- The robotized assay is suitable to identify RdRp inhibitors based on HTS

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