Ring-closing metathesis: development of a cyclisation–cleavage strategy for the solid-phase synthesis of cyclic sulfonamides

2004 ◽  
Vol 2 (6) ◽  
pp. 835-844 ◽  
Author(s):  
Jean-Dominique Moriggi ◽  
Lynda J. Brown ◽  
José L. Castro ◽  
Richard C. D. Brown
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Ring Closing Metathesis ◽  
Phase Synthesis ◽  
Cyclic Sulfonamides

scholarly journals The Pictet-Spengler Reaction Updates Its Habits

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 414 ◽  
Author(s):  
Andrea Calcaterra ◽  
Laura Mangiardi ◽  
Giuliano Delle Monache ◽  
Deborah Quaglio ◽  
Silvia Balducci ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Multicomponent Reaction ◽  
Michael Addition ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Synthetic Method ◽  
Ring Closing Metathesis ◽  
Phase Synthesis ◽  
Acid Catalyzed ◽  
High Yields

The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic frameworks. In the lustro (five-year period) following its centenary birthday, the P-S reaction did not exit the stage but it came up again on limelight with new features. This review focuses on the interesting results achieved in this period (2011–2015), analyzing the versatility of this reaction. Classic P-S was reported in the total synthesis of complex alkaloids, in combination with chiral catalysts as well as for the generation of libraries of compounds in medicinal chemistry. The P-S has been used also in tandem reactions, with the sequences including ring closing metathesis, isomerization, Michael addition, and Gold- or Brønsted acid-catalyzed N-acyliminium cyclization. Moreover, the combination of P-S reaction with Ugi multicomponent reaction has been exploited for the construction of highly complex polycyclic architectures in few steps and high yields. The P-S reaction has also been successfully employed in solid-phase synthesis, affording products with different structures, including peptidomimetics, synthetic heterocycles, and natural compounds. Finally, the enzymatic version of P-S has been reported for biosynthesis, biotransformations, and bioconjugations.

Synthesis of Diverse Macrocyclic Peptidomimetics Utilizing Ring-Closing Metathesis and Solid-Phase Synthesis

2004 ◽  
Vol 69 (4) ◽  
pp. 1028-1037 ◽  
Author(s):  
Anthony G. M. Barrett ◽  
Alan J. Hennessy ◽  
Ronan Le Vézouët ◽  
Panayiotis A. Procopiou ◽  
Peter W. Seale ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Ring Closing Metathesis ◽  
Phase Synthesis

Ring-Closing Metathesis Approaches for the Solid-Phase Synthesis of Cyclic Peptoids

2011 ◽  
Vol 13 (7) ◽  
pp. 1582-1585 ◽  
Author(s):  
Sharaf Nawaz Khan ◽  
Arim Kim ◽  
Robert H. Grubbs ◽  
Yong-Uk Kwon
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Ring Closing Metathesis ◽  
Phase Synthesis
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