On-chip separation of peptides prepared within a micro reactor

2003 ◽  
pp. 2886 ◽  
Author(s):  
Vinod George ◽  
Paul Watts ◽  
Stephen J. Haswell ◽  
Esteban Pombo-Villar
Keyword(s):  
On Chip ◽  
Chip Separation ◽  
Micro Reactor

On-chip separation of magnetic particles with different magnetophoretic mobilities

2007 ◽  
Vol 101 (2) ◽  
pp. 024913 ◽  
Author(s):  
Chengxun Liu ◽  
Liesbet Lagae ◽  
Roel Wirix-Speetjens ◽  
Gustaaf Borghs
Keyword(s):  
Magnetic Particles ◽  
On Chip ◽  
Chip Separation

The Design of a Continuous Flow Combinatorial Screening Micro Reactor System with On-Chip Detection

2000 ◽  
pp. 59-62
Author(s):  
Victoria Skelton ◽  
Gillian Greenway ◽  
Stephen Haswell ◽  
Peter Styring ◽  
David Morgan ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Reactor System ◽  
Combinatorial Screening ◽  
On Chip ◽  
Micro Reactor

On-chip separation of Lactobacillus bacteria from yeasts using dielectrophoresis

2011 ◽  
Vol 12 (1-4) ◽  
pp. 597-606 ◽  
Author(s):  
Khashayar Khoshmanesh ◽  
Sara Baratchi ◽  
Francisco J. Tovar-Lopez ◽  
Saeid Nahavandi ◽  
Donald Wlodkowic ◽  
...  
Keyword(s):  
On Chip ◽  
Chip Separation

Rapid chiral on-chip separation with simplified amperometric detection

2001 ◽  
Vol 928 (2) ◽  
pp. 225-232 ◽  
Author(s):  
Maria A Schwarz ◽  
Peter C Hauser
Keyword(s):  
Amperometric Detection ◽  
On Chip ◽  
Chip Separation

5 Zones Thermocycler for Flow-Through On-Chip PCR

2008 ◽  
Author(s):  
Jana Felbel ◽  
Anett Reichert ◽  
Mark Kielpinski ◽  
Matthias Urban ◽  
Thomas Henkel
Keyword(s):  
Small Volume ◽  
Clinical Diagnostics ◽  
Tumor Suppressor P53 ◽  
Flow Conditions ◽  
Microscope Slide ◽  
Micro Channels ◽  
Flow Through ◽  
On Chip ◽  
Conventional Systems ◽  
Micro Reactor

A microfluidic chip system for flow-through PCR reactions with an optimized thermal profile consisting of five temperature zones was presented. It allows the implementation of one PCR cycle in a half channel loop. In contrast, conventional systems with a three zones arrangement require a complete channel loop per cycle. Therefore, this arrangement increases the level of integration and allows the implementation of a 40 cycles flow-through thermocycler on the footprint of a microscope slide. To obtain a high throughput of samples in a small volume (10–100 nl), the fluidic chip device was designed to operate at segmented-flow conditions for PCR. That way, each droplet may contain a single sample that is independently processed while transported through the microchannel. To achieve stable fluidic conditions, the surface of the micro-channels was modified. In addition to the successful flow-through PCR reaction in the micro reactor, the detection of the tumor suppressor p53 for clinical diagnostics was demonstrated.

Chip Morphology Studies Using Separate Fracture Toughness Values for Chip Separation and Serration in Orthogonal Machining Simulations

2018 ◽  
Author(s):  
Jaimeen Patel ◽  
Harish P. Cherukuri
Keyword(s):  
Damage Evolution ◽  
Damage Model ◽  
Equivalent Plastic Strain ◽  
Chip Morphology ◽  
Threshold Value ◽  
Threshold Values ◽  
Orthogonal Machining ◽  
Evolution Laws ◽  
On Chip ◽  
Chip Separation

It is well known that the chip morphology predictions in machining simulations depend on the separation criteria used for modeling chip formation. In this paper, we propose to use two different criteria for chip separation and serration along with the Johnson-Cook damage model. The threshold value for chip separation is determined from machining experiments using the methodologies discussed in Patel et al. [1]. In addition, two separate damage evolution laws for chip separation and serration are used. Our results indicate that the choice of the evolution law and the threshold values of Gc used for chip separation and serration have a significant effect on chip shape and other field variables such as the equivalent plastic strain, cutting force, temperature, etc.

scholarly journals Recent Advances in Microfluidics-Based Chromatography—A Mini Review

Separations ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 3
Author(s):  
Bo Bao ◽  
Zhichao Wang ◽  
Dilantha Thushara ◽  
Achini Liyanage ◽  
Sanja Gunawardena ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Biomarker Discovery ◽  
Small Sample ◽  
Size Exclusion ◽  
Affinity Adsorption ◽  
Recent Advances ◽  
Different Types ◽  
On Chip ◽  
Chip Separation ◽  
Column Preparation

Microfluidics-based liquid chromatography is based on the miniaturization of the different types of liquid chromatography (LC) systems (e.g., affinity, adsorption, size exclusion, ion exchange) on a microchip to perform on-chip separation of different types of analytes. On-chip chromatography finds applications in genomics, proteomics, biomarker discovery, and environmental analysis. Microfluidics-based chromatography has good reproducibility and small sample consumption. However, the on-chip chromatography fabrication techniques are often more challenging to perform than conventional LC column preparation. Different research groups have attempted to develop different techniques to fabricate microfluidics-based LC systems. In this review, we will summarize the recent advances in microfluidics-based chromatography.

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